SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cb8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A4G_B_ZMRB466_2
(NEURAMINIDASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		3 / 3 ASP A 321
ARG A 325
ILE A 336
 None
 0.88A 1a4gB-1cb8A:
undetectable		 1a4gB-1cb8A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 TYR A  92
ASP A 103
VAL A 105
GLY A 101
 None
 1.03A 1ekjC-1cb8A:
undetectable
1ekjD-1cb8A:
undetectable		 1ekjC-1cb8A:
15.93
1ekjD-1cb8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ASP A 103
VAL A 105
GLY A 101
TYR A  92
 None
 1.04A 1ekjC-1cb8A:
undetectable
1ekjD-1cb8A:
undetectable		 1ekjC-1cb8A:
15.93
1ekjD-1cb8A:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F9G_A_ASCA950_0
(HYALURONATE LYASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		6 / 7 ASN A 125
TRP A 127
TYR A 234
ARG A 288
ARG A 292
ASN A 374
 None
None
GOL  A2010 (-3.9A)
GOL  A2010 ( 3.7A)
GOL  A2010 ( 2.6A)
None
 0.46A 1f9gA-1cb8A:
43.6		 1f9gA-1cb8A:
26.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 ALA A 461
PHE A 463
ALA A 446
ALA A 448
LEU A 662
 None
 1.12A 1rbpA-1cb8A:
1.5		 1rbpA-1cb8A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VE3_B_SAMB301_0
(HYPOTHETICAL PROTEIN
PH0226)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 GLY A 394
ILE A 276
SER A 279
ILE A 390
SER A 357
 None
 1.16A 1ve3B-1cb8A:
undetectable		 1ve3B-1cb8A:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.88A 1wmqA-1cb8A:
0.0		 1wmqA-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WMQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.88A 1wmqB-1cb8A:
0.0		 1wmqB-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.87A 1wpuA-1cb8A:
0.0		 1wpuA-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WPU_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.87A 1wpuB-1cb8A:
0.0		 1wpuB-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_A_HISA2001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.87A 1wrqA-1cb8A:
0.0		 1wrqA-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRQ_B_HISB1001_0
(HUT OPERON POSITIVE
REGULATORY PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ARG A 325
ILE A 336
GLY A 333
ALA A 331
 None
 0.89A 1wrqB-1cb8A:
0.0		 1wrqB-1cb8A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_A_GBNA502_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 TYR A 254
GLY A  26
THR A  27
ALA A  28
 None
 0.62A 2a1hA-1cb8A:
undetectable
2a1hB-1cb8A:
undetectable		 2a1hA-1cb8A:
19.21
2a1hB-1cb8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1H_B_GBNB501_1
(BRANCHED CHAIN
AMINOTRANSFERASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 TYR A 254
GLY A  26
THR A  27
ALA A  28
 None
 0.66A 2a1hA-1cb8A:
undetectable
2a1hB-1cb8A:
undetectable		 2a1hA-1cb8A:
19.21
2a1hB-1cb8A:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJT_A_SAMA501_1
(N(2),N(2)-DIMETHYLGU
ANOSINE TRNA
METHYLTRANSFERASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		3 / 3 ARG A 381
ASP A 452
ASP A 434
 None
 0.78A 2ejtA-1cb8A:
undetectable		 2ejtA-1cb8A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OD9_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		3 / 3 PHE A 512
PHE A 518
PHE A 529
 None
 0.79A 2od9A-1cb8A:
undetectable		 2od9A-1cb8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QQG_A_NCAA3721_0
(NAD-DEPENDENT
DEACETYLASE HST2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		3 / 3 PHE A 512
PHE A 518
PHE A 529
 None
 0.79A 2qqgA-1cb8A:
undetectable		 2qqgA-1cb8A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 THR A 367
GLN A 430
ASP A 347
SER A 364
 None
 1.23A 2xz5A-1cb8A:
0.0
2xz5C-1cb8A:
0.0		 2xz5A-1cb8A:
16.79
2xz5C-1cb8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 THR A 367
GLN A 430
ASP A 347
SER A 364
 None
 1.24A 2xz5C-1cb8A:
0.0
2xz5D-1cb8A:
0.0		 2xz5C-1cb8A:
16.79
2xz5D-1cb8A:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y69_N_CHDN1517_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.15A 2y69C-1cb8A:
undetectable
2y69N-1cb8A:
0.1
2y69P-1cb8A:
0.0		 2y69C-1cb8A:
16.94
2y69N-1cb8A:
21.65
2y69P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0A_D_GLYD73_0
(NONSTRUCTURAL
PROTEIN 1)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 4 ARG A 421
ASP A 407
SER A 414
ARG A 415
 GCU  A2002 (-2.7A)
CA  A3000 ( 2.2A)
None
GCU  A2002 (-2.8A)
 1.35A 2z0aC-1cb8A:
2.8
2z0aD-1cb8A:
2.8		 2z0aC-1cb8A:
9.69
2z0aD-1cb8A:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.17A 3ablC-1cb8A:
0.0
3ablN-1cb8A:
0.0
3ablP-1cb8A:
0.0		 3ablC-1cb8A:
16.94
3ablN-1cb8A:
21.65
3ablP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ASN_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.22A 3asnC-1cb8A:
0.0
3asnN-1cb8A:
0.0
3asnP-1cb8A:
0.0		 3asnC-1cb8A:
16.94
3asnN-1cb8A:
21.65
3asnP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BWY_A_SAMA301_0
(COMT PROTEIN)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 GLU A 396
GLY A 394
TYR A 398
ILE A 276
ARG A 325
 None
 1.43A 3bwyA-1cb8A:
undetectable		 3bwyA-1cb8A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EBZ_B_017B201_2
(PROTEASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 11 LEU A 296
GLY A 287
VAL A 237
GLY A 235
ILE A 231
 None
GOL  A2010 ( 4.3A)
None
None
None
 1.08A 3ebzB-1cb8A:
undetectable		 3ebzB-1cb8A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 383
SER A 384
LEU A 296
ILE A 409
 None
 0.90A 3ln1A-1cb8A:
0.0		 3ln1A-1cb8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 LEU A 383
SER A 384
LEU A 296
ILE A 409
 None
 0.91A 3ln1B-1cb8A:
0.0		 3ln1B-1cb8A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 5 TYR A 348
GLN A 350
ILE A 336
LEU A 352
 None
 1.25A 3ls4L-1cb8A:
undetectable		 3ls4L-1cb8A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3POC_B_ACRB665_1
(ALPHA-GLUCOSIDASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 GLU A 482
ASP A 407
TYR A 382
LYS A 408
 None
CA  A3000 ( 2.2A)
None
CA  A3000 ( 4.0A)
 1.39A 3pocB-1cb8A:
undetectable		 3pocB-1cb8A:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 HIS A 340
VAL A 349
VAL A 360
GLN A 342
 None
 1.15A 3uy4A-1cb8A:
undetectable		 3uy4A-1cb8A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WG7_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.21A 3wg7C-1cb8A:
0.0
3wg7N-1cb8A:
0.0
3wg7P-1cb8A:
0.0		 3wg7C-1cb8A:
16.94
3wg7N-1cb8A:
21.65
3wg7P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRK_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 5 PHE A 464
GLY A 411
ILE A 469
VAL A 582
 None
 0.87A 3wrkA-1cb8A:
0.3		 3wrkA-1cb8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3X2Q_P_CHDP308_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.16A 3x2qC-1cb8A:
0.0
3x2qN-1cb8A:
0.2
3x2qP-1cb8A:
0.0		 3x2qC-1cb8A:
16.94
3x2qN-1cb8A:
21.65
3x2qP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ASN A 489
ASP A 523
GLY A 394
THR A 388
 None
 1.04A 4l1aB-1cb8A:
0.0		 4l1aB-1cb8A:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODR_B_FK5B201_1
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD,
PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP1A CHIMERA)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 11 LEU A 305
ILE A 239
LEU A 243
TYR A 272
ILE A 276
 None
 0.96A 4odrA-1cb8A:
undetectable
4odrB-1cb8A:
undetectable		 4odrA-1cb8A:
12.45
4odrB-1cb8A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 PHE A 184
LEU A 181
THR A 252
VAL A  35
 None
 0.92A 4wnvD-1cb8A:
0.5		 4wnvD-1cb8A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_2
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 PRO A 410
ILE A 400
VAL A 290
ARG A 393
 None
 0.88A 4xe5A-1cb8A:
0.0		 4xe5A-1cb8A:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y03_A_SALA801_1
(PROTEIN POLYBROMO-1)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 ILE A  89
LEU A  82
ALA A 112
ILE A 109
 None
 0.86A 4y03A-1cb8A:
undetectable		 4y03A-1cb8A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB402_0
(GLYCINE OXIDASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 5 GLU A 371
TYR A 234
ARG A 292
ARG A 288
 None
GOL  A2010 (-3.9A)
GOL  A2010 ( 2.6A)
GOL  A2010 ( 3.7A)
 1.27A 4yshB-1cb8A:
0.0		 4yshB-1cb8A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 ASP A 416
LYS A 564
THR A 485
THR A 487
 CA  A3000 ( 3.5A)
None
None
None
 1.25A 4z4fA-1cb8A:
undetectable		 4z4fA-1cb8A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 ALA A 355
TYR A 356
LEU A 617
ILE A 650
HIS A 351
 None
 1.09A 5fsaA-1cb8A:
0.0		 5fsaA-1cb8A:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.19A 5iy5C-1cb8A:
0.0
5iy5N-1cb8A:
0.1
5iy5P-1cb8A:
0.0		 5iy5C-1cb8A:
16.86
5iy5N-1cb8A:
21.65
5iy5P-1cb8A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 6 LEU A 535
ILE A 409
THR A 487
TRP A 404
 None
 1.38A 5ljeA-1cb8A:
0.0		 5ljeA-1cb8A:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LSA_A_SAMA303_0
(CATECHOL
O-METHYLTRANSFERASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 GLU A 396
GLY A 394
TYR A 398
ILE A 276
ARG A 325
 None
 1.36A 5lsaA-1cb8A:
undetectable		 5lsaA-1cb8A:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SXQ_A_NIZA808_1
(CATALASE-PEROXIDASE)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 GLU A 371
GLY A 226
GLN A 230
LEU A 223
 None
None
GOL  A2010 ( 4.6A)
None
 0.88A 5sxqA-1cb8A:
0.0		 5sxqA-1cb8A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_G_CVIG301_1
(REGULATORY PROTEIN
TETR)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 GLY A 411
TRP A 462
ASP A 385
TYR A 382
 None
 1.22A 5vlmG-1cb8A:
2.7		 5vlmG-1cb8A:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 HIS A 340
ASP A 347
TYR A 348
LEU A 223
 None
 1.13A 5w97A-1cb8A:
0.0
5w97C-1cb8A:
0.0
5w97c-1cb8A:
0.0		 5w97A-1cb8A:
21.65
5w97C-1cb8A:
16.94
5w97c-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC302_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.17A 5w97C-1cb8A:
0.0
5w97a-1cb8A:
0.0
5w97c-1cb8A:
0.0		 5w97C-1cb8A:
16.94
5w97a-1cb8A:
21.65
5w97c-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X1F_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 HIS A 340
ASP A 347
TYR A 348
LEU A 223
 None
 1.12A 5x1fA-1cb8A:
undetectable
5x1fC-1cb8A:
0.0
5x1fP-1cb8A:
0.0		 5x1fA-1cb8A:
21.65
5x1fC-1cb8A:
16.94
5x1fP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDQ_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.20A 5xdqC-1cb8A:
0.0
5xdqN-1cb8A:
0.1
5xdqP-1cb8A:
0.0		 5xdqC-1cb8A:
16.94
5xdqN-1cb8A:
21.65
5xdqP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y9Y_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		3 / 3 LYS A 641
PRO A 642
LYS A 664
 None
 0.94A 5y9yA-1cb8A:
0.0		 5y9yA-1cb8A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 HIS A 340
ASP A 347
TYR A 348
LEU A 223
 None
 1.19A 5z84A-1cb8A:
0.0
5z84C-1cb8A:
0.0
5z84P-1cb8A:
0.0		 5z84A-1cb8A:
21.65
5z84C-1cb8A:
16.94
5z84P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.16A 5z84C-1cb8A:
0.0
5z84N-1cb8A:
0.0
5z84P-1cb8A:
0.0		 5z84C-1cb8A:
16.94
5z84N-1cb8A:
21.65
5z84P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 HIS A 340
ASP A 347
TYR A 348
LEU A 223
 None
 1.21A 5z85A-1cb8A:
0.1
5z85C-1cb8A:
0.0
5z85P-1cb8A:
0.0		 5z85A-1cb8A:
21.65
5z85C-1cb8A:
16.94
5z85P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z85_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.18A 5z85C-1cb8A:
0.0
5z85N-1cb8A:
0.2
5z85P-1cb8A:
0.0		 5z85C-1cb8A:
16.94
5z85N-1cb8A:
21.65
5z85P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z86_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.17A 5z86C-1cb8A:
0.0
5z86N-1cb8A:
0.2
5z86P-1cb8A:
0.0		 5z86C-1cb8A:
16.94
5z86N-1cb8A:
21.65
5z86P-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCO_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.19A 5zcoC-1cb8A:
0.0
5zcoN-1cb8A:
0.2
5zcoP-1cb8A:
0.0		 5zcoC-1cb8A:
16.94
5zcoN-1cb8A:
21.65
5zcoP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 HIS A 340
ASP A 347
TYR A 348
LEU A 223
 None
 1.19A 5zcpA-1cb8A:
0.0
5zcpC-1cb8A:
0.0
5zcpP-1cb8A:
0.0		 5zcpA-1cb8A:
21.65
5zcpC-1cb8A:
16.94
5zcpP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZCP_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.16A 5zcpC-1cb8A:
0.0
5zcpN-1cb8A:
0.3
5zcpP-1cb8A:
0.0		 5zcpC-1cb8A:
16.94
5zcpN-1cb8A:
21.65
5zcpP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_A_TLFA300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 PHE A 106
VAL A 105
VAL A 156
SER A 110
PHE A 113
 None
 1.36A 6ap6A-1cb8A:
undetectable		 6ap6A-1cb8A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AP6_B_TLFB300_0
(PROBABLE
STRIGOLACTONE
ESTERASE DAD2)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		5 / 12 PHE A 106
VAL A 105
VAL A 156
SER A 110
PHE A 113
 None
 1.36A 6ap6B-1cb8A:
undetectable		 6ap6B-1cb8A:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NKN_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 8 LEU A 223
HIS A 340
ASP A 347
TYR A 348
 None
 1.15A 6nknC-1cb8A:
undetectable
6nknN-1cb8A:
undetectable
6nknP-1cb8A:
undetectable		 6nknC-1cb8A:
16.94
6nknN-1cb8A:
21.65
6nknP-1cb8A:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NMF_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cb8 PROTEIN
(CHONDROITINASE AC)
(Pedobacter
heparinus) 		4 / 7 HIS A 340
ASP A 347
TYR A 348
LEU A 223
 None
 1.15A 6nmfA-1cb8A:
0.1
6nmfC-1cb8A:
0.0
6nmfP-1cb8A:
0.0		 6nmfA-1cb8A:
21.65
6nmfC-1cb8A:
16.94
6nmfP-1cb8A:
16.94