SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cbf'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TSN_A_C2FA266_0
(THYMIDYLATE SYNTHASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 ILE A 243
LEU A 155
LEU A 249
GLY A 246
ALA A 137
 None
 1.15A 1tsnA-1cbfA:
0.0		 1tsnA-1cbfA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UAK_A_SAMA301_0
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		6 / 12 LEU A  35
GLY A 129
VAL A 133
GLY A 102
GLY A  29
PRO A  30
 None
None
None
SAH  A 300 (-3.5A)
None
SAH  A 300 (-4.9A)
 1.29A 1uakA-1cbfA:
undetectable		 1uakA-1cbfA:
26.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 7 LEU A  23
LEU A 117
GLU A  70
ARG A  89
 None
 0.63A 2jn3A-1cbfA:
0.0		 2jn3A-1cbfA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_A_SAMA301_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		6 / 12 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
None
None
None
None
PO4  A 401 (-3.5A)
 1.07A 2yqzA-1cbfA:
3.3		 2yqzA-1cbfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YQZ_B_SAMB401_0
(HYPOTHETICAL PROTEIN
TTHA0223)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		6 / 12 GLY A  29
GLY A 129
ILE A  26
LEU A  35
ALA A 135
HIS A 100
 None
None
None
None
None
PO4  A 401 (-3.5A)
 1.05A 2yqzB-1cbfA:
3.4		 2yqzB-1cbfA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FZG_A_SAMA300_0
(16S RRNA METHYLASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 THR A  37
GLY A 102
GLY A 129
LEU A  35
VAL A  57
 None
SAH  A 300 (-3.5A)
None
None
None
 1.12A 3fzgA-1cbfA:
undetectable		 3fzgA-1cbfA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 GLY A 102
GLY A  27
THR A  37
ALA A 135
ALA A 105
 SAH  A 300 (-3.5A)
None
None
None
None
 1.07A 3g89A-1cbfA:
undetectable		 3g89A-1cbfA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G89_B_SAMB303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 11 GLY A 102
GLY A  27
THR A  37
ALA A 135
ALA A 105
 SAH  A 300 (-3.5A)
None
None
None
None
 1.07A 3g89B-1cbfA:
0.2		 3g89B-1cbfA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G8B_A_SAMA303_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE G)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 12 GLY A 102
GLY A  27
THR A  37
ALA A 135
ALA A 105
 SAH  A 300 (-3.5A)
None
None
None
None
 1.09A 3g8bA-1cbfA:
0.3		 3g8bA-1cbfA:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPB_D_SAMD1000_0
(UNCHARACTERIZED
PROTEIN MJ0100)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 10 TRP A 247
THR A 150
VAL A 153
ILE A 154
ILE A 180
 None
 1.22A 3kpbD-1cbfA:
undetectable		 3kpbD-1cbfA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NS1_C_PM6C1_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 6 GLU A 218
ARG A 222
ALA A 139
ALA A 140
 None
 1.17A 3ns1C-1cbfA:
0.0		 3ns1C-1cbfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RF4_C_FUNC203_1
(MACROPHAGE MIGRATION
INHIBITORY FACTOR)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 11 ILE A  36
SER A  65
ILE A  62
VAL A  99
VAL A  57
 None
 1.37A 3rf4B-1cbfA:
0.0
3rf4C-1cbfA:
0.0		 3rf4B-1cbfA:
18.15
3rf4C-1cbfA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOG_D_C2FD302_0
(THYMIDYLATE SYNTHASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 11 ILE A 243
LEU A 155
LEU A 249
GLY A 246
ALA A 137
 None
 1.19A 4fogD-1cbfA:
0.0		 4fogD-1cbfA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L3G_F_ACTF401_0
(METHYLAMINE
DEHYDROGENASE HEAVY
CHAIN)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		3 / 3 ARG A 119
LEU A 116
GLU A 120
 None
 0.66A 4l3gF-1cbfA:
0.0		 4l3gF-1cbfA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FXF_B_BEZB601_0
(EUGENOL OXIDASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 10 ASP A  54
VAL A  71
TYR A  52
GLN A  59
ILE A  62
 None
 1.37A 5fxfB-1cbfA:
0.0		 5fxfB-1cbfA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZHM_B_SAMB301_1
(TRNA
(GUANINE-N(1)-)-METH
YLTRANSFERASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		6 / 12 LEU A  35
GLY A 129
VAL A 133
GLY A 102
GLY A  29
PRO A  30
 None
None
None
SAH  A 300 (-3.5A)
None
SAH  A 300 (-4.9A)
 1.35A 5zhmB-1cbfA:
3.0		 5zhmB-1cbfA:
24.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_B_PQNB842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		5 / 10 ILE A 220
ILE A 146
ALA A 248
LEU A 249
ALA A 245
 None
 1.30A 5zjiB-1cbfA:
0.0		 5zjiB-1cbfA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_C_FK5C201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 4 ASP A 250
ILE A 146
PRO A 147
LEU A 149
 None
 1.19A 6mkeB-1cbfA:
0.0		 6mkeB-1cbfA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MKE_D_FK5D201_0
(PEPTIDYLPROLYL
ISOMERASE)		 1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE
(Bacillus
megaterium) 		4 / 4 ASP A 250
ILE A 146
PRO A 147
LEU A 149
 None
 1.29A 6mkeA-1cbfA:
0.0		 6mkeA-1cbfA:
15.44