SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cbg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA495_1
(GLUCOAMYLASE-471)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 12 ALA A  38
ASP A  49
GLY A 103
TYR A 117
GLU A  35
 None
 1.33A 1agmA-1cbgA:
undetectable		 1agmA-1cbgA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AGM_A_ACRA496_1
(GLUCOAMYLASE-471)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 12 ALA A  38
ASP A  49
GLY A 103
TYR A 117
GLU A  35
 None
 1.33A 1agmA-1cbgA:
undetectable		 1agmA-1cbgA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_A_VDYA1002_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 ILE A 377
LEU A 380
VAL A 384
 None
 0.39A 1mz9B-1cbgA:
undetectable		 1mz9B-1cbgA:
8.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_2
(ORPHAN NUCLEAR
RECEPTOR PXR)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 5 PHE A 444
LEU A 488
MET A  82
LEU A 125
 None
 1.15A 1skxA-1cbgA:
0.0		 1skxA-1cbgA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DCF_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 ALA A 365
TYR A 422
TRP A 369
ILE A 372
 None
 1.18A 2dcfA-1cbgA:
0.0		 2dcfA-1cbgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 5 PHE A  23
PHE A  25
PHE A 487
VAL A 430
 None
 1.19A 2lh6A-1cbgA:
0.9		 2lh6A-1cbgA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 PRO A 406
ASN A 404
ARG A 461
 None
 1.01A 2qeuB-1cbgA:
0.7		 2qeuB-1cbgA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RHM_B_BEZB194_0
(PUTATIVE KINASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 5 PRO A 418
ILE A 420
ARG A 419
ASP A 416
 None
 1.45A 2rhmB-1cbgA:
undetectable		 2rhmB-1cbgA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V3D_B_NBVB1504_1
(GLUCOSYLCERAMIDASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 11 ASN A 182
GLU A 183
TYR A 326
GLU A 397
TRP A 446
 None
 0.80A 2v3dB-1cbgA:
2.5		 2v3dB-1cbgA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZM7_A_ACAA501_1
(6-AMINOHEXANOATE-DIM
ER HYDROLASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 7 ALA A 365
TYR A 422
TRP A 369
ILE A 372
 None
 1.12A 2zm7A-1cbgA:
0.0		 2zm7A-1cbgA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CCF_B_BEZB261_0
(CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 8 ILE A 344
TRP A 281
PHE A 277
ARG A 302
 None
 1.23A 3ccfB-1cbgA:
undetectable		 3ccfB-1cbgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I9J_B_NCAB302_0
(ADP-RIBOSYL CYCLASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 ASN A 401
TRP A 369
SER A 327
PHE A 354
 None
 1.40A 3i9jB-1cbgA:
1.6		 3i9jB-1cbgA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP3_B_AICB2001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 10 GLU A 402
ASN A 451
LEU A 464
GLU A 397
ARG A 419
 None
 1.41A 3kp3A-1cbgA:
undetectable
3kp3B-1cbgA:
0.0		 3kp3A-1cbgA:
15.66
3kp3B-1cbgA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 LYS A 478
ARG A 419
ASP A 405
 None
 1.30A 3o7wA-1cbgA:
0.9		 3o7wA-1cbgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_0
(GLYCINE
N-METHYLTRANSFERASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 LEU A 181
HIS A 230
THR A 252
ARG A  91
 None
 1.25A 3thrB-1cbgA:
1.0		 3thrB-1cbgA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TPX_E_ACTE204_0
(E3 UBIQUITIN-PROTEIN
LIGASE MDM2)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 LYS A 359
PRO A 360
LEU A 361
 None
 0.87A 3tpxE-1cbgA:
0.0		 3tpxE-1cbgA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 TYR A 383
ASP A 276
ASP A 269
 None
 0.49A 4a6eA-1cbgA:
undetectable		 4a6eA-1cbgA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4B17_A_SAMA1358_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE M)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 12 GLY A 195
GLY A 212
GLY A 213
ASP A 455
VAL A 187
 None
 0.97A 4b17A-1cbgA:
undetectable		 4b17A-1cbgA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_A_PXLA300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 7 GLY A  36
ASP A  66
GLY A  65
HIS A  53
 None
 0.77A 4c5nA-1cbgA:
2.4		 4c5nA-1cbgA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C5N_C_PXLC300_1
(PHOSPHOMETHYLPYRIMID
INE KINASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 8 GLY A  36
ASP A  66
GLY A  65
HIS A  53
 None
 0.77A 4c5nC-1cbgA:
2.5		 4c5nC-1cbgA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HYF_A_NCAA1201_0
(TANKYRASE-2)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 7 HIS A 137
TYR A  34
ALA A  31
SER A  93
GLU A  71
 None
 1.49A 4hyfA-1cbgA:
undetectable		 4hyfA-1cbgA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_1
(METHYLTRANSFERASE
MPPJ)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 ARG A 290
ASP A 276
ASP A 269
 None
 0.85A 4kicB-1cbgA:
0.0		 4kicB-1cbgA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_B_FOLB301_1
(FOLATE RECEPTOR
ALPHA)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 ASP A 139
TRP A 446
SER A  93
 None
 0.88A 4lrhB-1cbgA:
0.0		 4lrhB-1cbgA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LRH_F_FOLF301_1
(FOLATE RECEPTOR
ALPHA)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 ASP A 139
TRP A 446
SER A  93
 None
 0.96A 4lrhF-1cbgA:
0.0		 4lrhF-1cbgA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U15_A_0HKA2001_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,LYSOZYME,MUSCARIN
IC ACETYLCHOLINE
RECEPTOR M3)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 ASN A 182
PHE A 444
TYR A  90
 None
 0.67A 4u15A-1cbgA:
0.0		 4u15A-1cbgA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 LEU A 236
VAL A 157
ASP A 158
 None
 0.41A 4y8wC-1cbgA:
0.0		 4y8wC-1cbgA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 ILE A  81
PHE A 449
ARG A 475
GLU A  71
 None
 1.28A 4zzcA-1cbgA:
0.0
4zzcB-1cbgA:
0.0		 4zzcA-1cbgA:
20.52
4zzcB-1cbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 ILE A  81
PHE A 449
ARG A 475
GLU A  71
 None
 1.25A 4zzcB-1cbgA:
undetectable
4zzcC-1cbgA:
undetectable		 4zzcB-1cbgA:
20.52
4zzcC-1cbgA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 5 GLU A 397
THR A 396
HIS A 387
LEU A 279
 None
 1.08A 5axaA-1cbgA:
undetectable		 5axaA-1cbgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 5 GLU A 397
THR A 396
HIS A 387
LEU A 279
 None
 1.05A 5axaC-1cbgA:
undetectable		 5axaC-1cbgA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 12 ILE A 393
VAL A 392
GLY A 442
ARG A  91
VAL A 175
 None
 1.20A 5ergB-1cbgA:
undetectable		 5ergB-1cbgA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 7 HIS A 426
ILE A 372
TYR A 325
GLN A 375
 None
 1.27A 5kkzM-1cbgA:
0.0
5kkzO-1cbgA:
0.0		 5kkzM-1cbgA:
17.50
5kkzO-1cbgA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L6E_A_SAMA601_1
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 ASP A 450
ASP A 455
ASN A 451
GLN A  33
 None
 1.16A 5l6eA-1cbgA:
undetectable		 5l6eA-1cbgA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 SER A 327
TYR A 326
TYR A 325
 None
 0.80A 5lakA-1cbgA:
0.0
5lakI-1cbgA:
undetectable		 5lakA-1cbgA:
20.17
5lakI-1cbgA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		3 / 3 SER A 327
TYR A 326
TYR A 325
 None
 0.69A 5lakC-1cbgA:
0.0
5lakJ-1cbgA:
undetectable		 5lakC-1cbgA:
20.17
5lakJ-1cbgA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZY_A_CE3A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 7 ASN A 398
THR A 252
ILE A 395
GLY A 322
 None
 0.99A 5nzyA-1cbgA:
1.4		 5nzyA-1cbgA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TUI_B_CTCB405_0
(TETRACYCLINE
DESTRUCTASE TET(50))		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		5 / 12 THR A 396
GLY A 322
PRO A 184
GLY A 186
PHE A 197
 None
 1.08A 5tuiB-1cbgA:
undetectable		 5tuiB-1cbgA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EKU_A_ZMRA901_2
(SIALIDASE)		 1cbg CYANOGENIC
BETA-GLUCOSIDASE
(Trifolium
repens) 		4 / 6 ASP A 347
GLN A 345
LEU A 206
SER A 203
 None
 0.81A 6ekuA-1cbgA:
0.0		 6ekuA-1cbgA:
21.60