SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cc1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 LEU L 387
PHE L 213
ALA L 391
GLY L 106
TYR L 109
 None
 1.30A 1brpA-1cc1L:
0.0		 1brpA-1cc1L:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DF7_A_MTXA501_2
(DIHYDROFOLATE
REDUCTASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 TRP L 386
ARG L 377
THR L 385
 None
 0.90A 1df7A-1cc1L:
undetectable		 1df7A-1cc1L:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_H_ACTH3006_0
(BETA-CARBONIC
ANHYDRASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 6 CYH L  73
VAL L  72
HIS L  77
CYH L 495
 FCO  L 499 ( 2.2A)
NI  L 500 ( 4.9A)
FCO  L 499 (-3.9A)
FCO  L 499 (-2.3A)
 1.29A 1ekjG-1cc1L:
undetectable
1ekjH-1cc1L:
undetectable		 1ekjG-1cc1L:
17.33
1ekjH-1cc1L:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_D_BRLD503_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.30A 1fm6D-1cc1L:
0.0		 1fm6D-1cc1L:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_X_BRLX504_1
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.30A 1fm6X-1cc1L:
0.0		 1fm6X-1cc1L:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 4 VAL L 332
TRP L 245
TRP L 450
 None
 1.33A 1gmkC-1cc1L:
undetectable
1gmkD-1cc1L:
undetectable		 1gmkC-1cc1L:
8.33
1gmkD-1cc1L:
8.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KF6_B_ACTB704_0
(FUMARATE REDUCTASE
FLAVOPROTEIN
FUMARATE REDUCTASE
IRON-SULFUR PROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 ARG L  21
GLY L 483
ASP L 124
 None
 0.50A 1kf6A-1cc1L:
2.0
1kf6B-1cc1L:
0.0		 1kf6A-1cc1L:
22.45
1kf6B-1cc1L:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OQ5_A_CELA701_2
(CARBONIC ANHYDRASE
II)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 4 HIS L 498
VAL L 445
THR L 307
LEU L 300
 FE2  L 501 (-3.5A)
None
None
None
 1.44A 1oq5A-1cc1L:
0.0		 1oq5A-1cc1L:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P9G_A_ACTA42_0
(EAFP 2)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 CYH L  73
ARG L 425
CYH L  70
 FCO  L 499 ( 2.2A)
FCO  L 499 (-4.1A)
NI  L 500 ( 2.2A)
 1.47A 1p9gA-1cc1L:
undetectable		 1p9gA-1cc1L:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RMT_A_ADNA1501_1
(CLASS B ACID
PHOSPHATASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 10 ASP L 258
THR L  94
GLY L  97
THR L 262
TYR L 260
 None
 1.38A 1rmtA-1cc1L:
0.0		 1rmtA-1cc1L:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 5 PRO L 479
VAL L 473
ASN L 481
VAL L  37
ILE L  14
 None
 1.49A 1z2bC-1cc1L:
undetectable		 1z2bC-1cc1L:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 6 ASP L 124
TYR L 118
PHE L 134
LEU L 162
 None
 0.99A 2w98A-1cc1L:
undetectable
2w98B-1cc1L:
undetectable		 2w98A-1cc1L:
20.66
2w98B-1cc1L:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 6 TYR L 125
TYR L 118
PHE L 134
LEU L 162
 None
 1.20A 2w98A-1cc1L:
undetectable
2w98B-1cc1L:
undetectable		 2w98A-1cc1L:
20.66
2w98B-1cc1L:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 SER L 112
ARG L 172
GLN L 111
 FCO  L 499 ( 4.8A)
None
None
 0.76A 2xnrA-1cc1L:
0.0		 2xnrA-1cc1L:
12.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 10 PHE L 105
GLY L 106
ALA L 391
PHE L 254
THR L 385
 H2S  L 502 (-4.7A)
None
None
None
None
 1.41A 3a3yA-1cc1L:
0.0		 3a3yA-1cc1L:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 11 THR L 405
GLY L 191
ILE L  99
ASN L 102
LEU L 103
 None
 0.97A 3dcmX-1cc1L:
undetectable		 3dcmX-1cc1L:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 GLN L 111
ASP L 490
PHE L 117
ALA L 121
ALA L 122
 None
 1.09A 3keeD-1cc1L:
undetectable		 3keeD-1cc1L:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OKX_B_SAMB201_0
(YAEB-LIKE PROTEIN
RPA0152)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 LYS L 370
ARG L 377
LYS L 328
 None
 1.38A 3okxA-1cc1L:
undetectable		 3okxA-1cc1L:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 GLN L 111
ASP L 490
PHE L 117
ALA L 121
ALA L 122
 None
 1.10A 3sudA-1cc1L:
undetectable		 3sudA-1cc1L:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 PHE L 420
GLY L 419
ARG L 425
GLY L 252
ALA L 423
 None
None
FCO  L 499 (-4.1A)
None
FCO  L 499 (-3.1A)
 1.14A 3sueD-1cc1L:
undetectable		 3sueD-1cc1L:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 11 GLN L 111
ASP L 490
PHE L 117
ALA L 121
ALA L 122
 None
 1.18A 3sufC-1cc1L:
undetectable		 3sufC-1cc1L:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TAJ_A_NBOA700_1
(LACTOTRANSFERRIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 7 GLY L 462
PRO L 454
TYR L 317
GLY L  44
 None
 0.79A 3tajA-1cc1L:
undetectable		 3tajA-1cc1L:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VM4_A_IZPA1_1
(FATTY ACID
ALPHA-HYDROXYLASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 5 LEU L 265
ARG L 337
PRO L 334
ALA L 336
 None
 1.44A 3vm4A-1cc1L:
0.0		 3vm4A-1cc1L:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.35A 4emaA-1cc1L:
undetectable		 4emaA-1cc1L:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FJP_A_NPSA711_1
(LACTOTRANSFERRIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 6 GLY L 462
PRO L 454
TYR L 317
GLY L  44
 None
 0.73A 4fjpA-1cc1L:
undetectable		 4fjpA-1cc1L:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FOR_A_FLPA711_1
(LACTOTRANSFERRIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 7 GLY L 462
PRO L 454
TYR L 317
GLY L  44
 None
 0.71A 4forA-1cc1L:
undetectable		 4forA-1cc1L:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MA3_L_ACTL301_0
(C2095 HEAVY CHAIN
C2095 LIGHT CHAIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 PRO L  74
ASN L 108
HIS L 176
 None
H2S  L 502 (-4.0A)
None
 1.00A 4ma3H-1cc1L:
0.0
4ma3L-1cc1L:
0.0		 4ma3H-1cc1L:
15.86
4ma3L-1cc1L:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 PRO L  59
ALA L  88
ALA L  80
GLY L 419
LEU L 429
 None
 1.01A 4oaeA-1cc1L:
undetectable		 4oaeA-1cc1L:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_A_SVRA205_2
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 6 LEU L 449
ASN L 453
PRO L 323
ARG L 337
 None
 1.35A 4yv5B-1cc1L:
undetectable		 4yv5B-1cc1L:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YV5_B_SVRB207_1
(BASIC PHOSPHOLIPASE
A2 HOMOLOG 2)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 6 LEU L 449
ASN L 453
PRO L 323
ARG L 337
 None
 1.30A 4yv5A-1cc1L:
undetectable		 4yv5A-1cc1L:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWY_E_010E6_0
(N-[(5-METHYLISOXAZOL
-3-YL)CARBONYL]ALANY
L-L-VALYL-N~1~-((1R,
2Z)-4-(BENZYLOXY)-4-
OXO-1-{[(3R)-2-OXOPY
RROLIDIN-3-YL]METHYL
}BUT-2-ENYL)-L-LEUCI
NAMIDE
MAIN PROTEASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 4 THR L 421
LEU L 428
HIS L  77
GLY L 426
 None
FCO  L 499 (-3.5A)
FCO  L 499 (-3.9A)
None
 1.24A 5gwyA-1cc1L:
0.0		 5gwyA-1cc1L:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JWA_H_ACTH612_0
(NADH DEHYDROGENASE,
PUTATIVE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 ARG L 425
PRO L 424
ASN L 108
 FCO  L 499 (-4.1A)
FCO  L 499 ( 3.5A)
H2S  L 502 (-4.0A)
 0.98A 5jwaA-1cc1L:
0.0
5jwaH-1cc1L:
0.0		 5jwaA-1cc1L:
23.08
5jwaH-1cc1L:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KF8_A_GCSA404_1
(PREDICTED
ACETYLTRANSFERASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 8 ARG L 377
GLU L 331
GLY L 462
PRO L 463
 None
 1.15A 5kf8A-1cc1L:
0.0		 5kf8A-1cc1L:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KGP_A_GCSA407_1
(PREDICTED
ACETYLTRANSFERASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 8 ARG L 377
GLU L 331
GLY L 462
PRO L 463
 None
 1.13A 5kgpA-1cc1L:
0.0		 5kgpA-1cc1L:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 8 VAL L 486
ILE L 464
ALA L 452
HIS L 378
VAL L  22
 None
 1.42A 5l94A-1cc1L:
0.0		 5l94A-1cc1L:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 ILE L  14
VAL L 471
LEU L 468
VAL L  30
ILE L  28
 None
 0.83A 5mueA-1cc1L:
undetectable		 5mueA-1cc1L:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_2
(TUBULIN BETA-2B
CHAIN)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 THR L 418
PRO L 267
ARG L 337
 None
 0.53A 5nd7B-1cc1L:
undetectable		 5nd7B-1cc1L:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NU7_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 4)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		4 / 8 LEU L 231
TYR L 118
GLN L 164
HIS L 116
 None
 0.88A 5nu7A-1cc1L:
0.0		 5nu7A-1cc1L:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U63_A_ACTA405_0
(THIOREDOXIN
REDUCTASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 GLY L 299
LEU L 300
HIS L 294
 None
 0.70A 5u63A-1cc1L:
undetectable		 5u63A-1cc1L:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHB_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 PHE L 239
ASP L 237
LEU L 468
 None
 0.76A 5uhbC-1cc1L:
0.0		 5uhbC-1cc1L:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UHC_C_RFPC1201_2
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		3 / 3 PHE L 239
ASP L 237
LEU L 468
 None
 0.74A 5uhcC-1cc1L:
0.0		 5uhcC-1cc1L:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2O_A_8N6A501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 CYH L 492
HIS L 498
HIS L  77
LEU L 428
LEU L 449
 NI  L 500 (-2.4A)
FE2  L 501 (-3.5A)
FCO  L 499 (-3.9A)
FCO  L 499 (-3.5A)
None
 1.31A 5y2oA-1cc1L:
0.0		 5y2oA-1cc1L:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1cc1 HYDROGENASE (LARGE
SUBUNIT)
(Desulfomicrobium
baculatum) 		5 / 12 PHE L 420
GLY L 419
ARG L 425
GLY L 252
ALA L 423
 None
None
FCO  L 499 (-4.1A)
None
FCO  L 499 (-3.1A)
 1.15A 6c2mB-1cc1L:
0.0		 6c2mB-1cc1L:
11.76