SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ccw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CBS_A_REAA200_1
(CELLULAR RETINOIC
ACID BINDING PROTEIN
TYPE II)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 LEU B 351
ILE B 314
ALA B 315
ALA B 320
THR B 249
 None
 1.09A 1cbsA-1ccwB:
undetectable		 1cbsA-1ccwB:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FIQ_C_SALC1335_1
(XANTHINE OXIDASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 8 LEU B 200
PHE B  13
VAL B  20
LEU B  21
 None
 0.77A 1fiqC-1ccwB:
0.0		 1fiqC-1ccwB:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 10 THR B  94
GLY B 124
LEU B 158
THR B  99
GLY B 127
 TAR  B 900 (-4.2A)
None
None
None
None
 1.31A 1h4oA-1ccwB:
0.3
1h4oB-1ccwB:
0.3		 1h4oA-1ccwB:
18.20
1h4oB-1ccwB:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I7Z_A_COCA301_1
(CHIMERA OF IG KAPPA
CHAIN: HUMAN
CONSTANT REGION AND
MOUSE VARIABLE
REGION)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 8 TYR B 204
TYR B  38
LEU B  32
GLU B  29
 None
 1.02A 1i7zA-1ccwB:
undetectable		 1i7zA-1ccwB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AQU_B_DR7B300_1
(HIV-1 PROTEASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 10 ALA B 240
GLY B 173
ILE B 175
VAL B 250
ILE B 248
 None
 0.95A 2aquA-1ccwB:
undetectable		 2aquA-1ccwB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EJ3_B_GBNB914_1
(BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 10 TYR B 279
GLY B 389
GLY B 394
THR B 395
ALA B 392
 None
 0.92A 2ej3B-1ccwB:
undetectable		 2ej3B-1ccwB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HMA_A_SAMA375_0
(PROBABLE TRNA
(5-METHYLAMINOMETHYL
-2-THIOURIDYLATE)-ME
THYLTRANSFERASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 11 SER B 176
ASN B 170
THR B 152
GLY B 151
HIS B 150
 None
None
None
TAR  B 900 ( 4.7A)
None
 1.34A 2hmaA-1ccwB:
undetectable		 2hmaA-1ccwB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HRC_A_CHDA703_0
(FERROCHELATASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 4 LEU B 146
PRO B 145
LEU B  91
ARG B  80
 None
 1.32A 2hrcA-1ccwB:
0.3		 2hrcA-1ccwB:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB501_1
(CYTOCHROME P450 2C8)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 9 GLY B  68
THR B 347
PRO B  92
ILE B 324
VAL B 323
 None
 1.30A 2nnhB-1ccwB:
0.0		 2nnhB-1ccwB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		3 / 3 ARG B 266
VAL B 323
THR B  61
 None
 0.84A 2nnkA-1ccwB:
0.0		 2nnkA-1ccwB:
12.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 SER B  93
GLY B 131
VAL B 132
GLY B 165
HIS B  75
 None
 1.40A 3f8wB-1ccwB:
undetectable		 3f8wB-1ccwB:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCO_A_CHDA3_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 4 LEU B 146
PRO B 145
LEU B  91
ARG B  80
 None
 1.42A 3hcoA-1ccwB:
undetectable		 3hcoA-1ccwB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_C_VIAC901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 7 TYR B 177
HIS B 150
LEU B 191
VAL B 245
 TAR  B 900 (-4.6A)
None
None
None
 1.13A 3jwqC-1ccwB:
undetectable		 3jwqC-1ccwB:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_1
(16S RRNA METHYLASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 5 ASN B 212
ASP B 198
THR B 235
SER B 169
 None
 1.40A 3p2kC-1ccwB:
undetectable		 3p2kC-1ccwB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		3 / 3 ARG B 266
VAL B 323
THR B  61
 None
 0.83A 3pwrA-1ccwB:
0.0		 3pwrA-1ccwB:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 8 LEU B 200
PHE B  13
VAL B  20
LEU B  21
 None
 0.77A 3uniB-1ccwB:
0.5		 3uniB-1ccwB:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AE1_B_NCAB1536_0
(DIPHTHERIA TOXIN)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 5 HIS B 291
GLY B 251
TYR B 252
GLU B 254
 TAR  B 900 (-4.7A)
None
None
None
 1.46A 4ae1B-1ccwB:
0.0		 4ae1B-1ccwB:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D1Y_A_RBFA1176_1
(PUTATIVE PROTEASE I)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 8 GLN B 195
ASN B   5
GLN B 243
THR B   9
 None
 1.08A 4d1yA-1ccwB:
undetectable
4d1yB-1ccwB:
undetectable		 4d1yA-1ccwB:
16.53
4d1yB-1ccwB:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 10 ALA B 240
GLY B 173
ILE B 175
VAL B 250
ILE B 248
 None
 0.98A 4dqcA-1ccwB:
undetectable		 4dqcA-1ccwB:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 6 ILE B 406
ASN B 414
GLU B 432
VAL B 466
 None
 1.04A 4ejwB-1ccwB:
0.2		 4ejwB-1ccwB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J4V_A_SVRA301_1
(NUCLEOCAPSID PROTEIN)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 11 ALA B 237
VAL B 232
MET B 404
PHE B 399
ILE B 187
 None
 1.43A 4j4vA-1ccwB:
0.0		 4j4vA-1ccwB:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LJ0_A_ACTA505_0
(NAB2)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		3 / 3 LEU B 380
LYS B 377
THR B 376
 None
 0.52A 4lj0A-1ccwB:
0.0		 4lj0A-1ccwB:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA301_1
(CHITOSANASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 4 ASP B 198
GLY B 172
PRO B 215
GLN B 147
 None
 1.38A 4oltA-1ccwB:
0.0		 4oltA-1ccwB:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R7L_A_SHHA709_1
(LEUKOTRIENE A-4
HYDROLASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 GLN B 147
ALA B 148
HIS B 291
GLU B 214
TYR B 177
 None
None
TAR  B 900 (-4.7A)
None
TAR  B 900 (-4.6A)
 1.47A 4r7lA-1ccwB:
undetectable		 4r7lA-1ccwB:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZGF_A_BEZA210_0
(UNCHARACTERIZED
PROTEIN)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 4 VAL B 396
ALA B 392
ASN B   5
GLN B 195
 None
 1.49A 4zgfA-1ccwB:
0.0		 4zgfA-1ccwB:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 ASP B 198
ALA B 148
GLY B 174
LEU B 158
GLY B 217
 None
 0.99A 5i73A-1ccwB:
0.0		 5i73A-1ccwB:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGZ_A_SPRA404_2
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 9 LEU B 200
ILE B 211
HIS B 163
GLU B  11
PHE B  13
 None
 1.27A 5igzA-1ccwB:
0.0		 5igzA-1ccwB:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IZF_E_AZ1E2_1
(CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA
6J9-ZEU-DAR-ACA-DAR-
NH2)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 7 GLY B 165
GLY B 131
LEU B 157
GLU B  34
 None
 0.87A 5izfA-1ccwB:
undetectable		 5izfA-1ccwB:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		3 / 3 THR B 152
SER B 155
ASP B 198
 None
 0.76A 5kvaA-1ccwB:
0.8		 5kvaA-1ccwB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_1
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		3 / 3 THR B 152
SER B 155
ASP B 198
 None
 0.75A 5kvaB-1ccwB:
1.4		 5kvaB-1ccwB:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 LEU B 157
VAL B 132
GLY B 131
GLY B 127
TYR B 104
 None
 1.22A 5nnaC-1ccwB:
0.0		 5nnaC-1ccwB:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ODC_G_ACTG704_0
(HETERODISULFIDE
REDUCTASE, SUBUNIT A)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 5 PRO B 145
GLN B 147
LYS B 322
GLN B  64
 None
 1.24A 5odcA-1ccwB:
undetectable
5odcG-1ccwB:
1.2		 5odcA-1ccwB:
21.20
5odcG-1ccwB:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZJI_A_PQNA844_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 10 SER B 176
GLY B 173
ILE B 248
ALA B 240
LEU B 239
 None
 1.31A 5zjiA-1ccwB:
undetectable
5zjiJ-1ccwB:
0.0		 5zjiA-1ccwB:
10.49
5zjiJ-1ccwB:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B3A_A_SAMA701_0
(APRA
METHYLTRANSFERASE 1)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 HIS B 291
MET B 228
GLY B 233
ILE B 406
LEU B 219
 TAR  B 900 (-4.7A)
None
None
None
None
 1.11A 6b3aA-1ccwB:
undetectable		 6b3aA-1ccwB:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		5 / 12 GLY B  27
ARG B 213
ILE B  95
GLY B 131
ALA B 159
 None
 1.05A 6c2mD-1ccwB:
0.0		 6c2mD-1ccwB:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 8 LEU B  39
TYR B  38
GLU B 140
THR B 168
 None
 1.23A 6c71B-1ccwB:
undetectable		 6c71B-1ccwB:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA826_0
(GEPHYRIN)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		3 / 3 HIS B 291
ARG B 149
ILE B 324
 TAR  B 900 (-4.7A)
TAR  B 900 (-3.8A)
None
 0.61A 6fgdA-1ccwB:
undetectable		 6fgdA-1ccwB:
24.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GQI_A_ACTA604_0
(CYCLOHEXANONE
MONOOXYGENASE FROM
THERMOCRISPUM
MUNICIPALE)		 1ccw PROTEIN (GLUTAMATE
MUTASE)
(Clostridium
cochlearium) 		4 / 6 ILE B 211
GLY B 202
TYR B 204
GLU B 205
 None
 0.91A 6gqiA-1ccwB:
0.4		 6gqiA-1ccwB:
22.74