SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cem'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G72_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLY A 370
TYR A  90
ASN A 374
ASP A 319
 None
 1.07A 2g72B-1cemA:
undetectable		 2g72B-1cemA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J9C_A_ACTA1122_0
(HYPOTHETICAL
NITROGEN REGULATORY
PII-LIKE PROTEIN
MJ0059)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 7 SER A 208
VAL A 198
LYS A 239
SER A 264
 None
 1.45A 2j9cA-1cemA:
undetectable
2j9cB-1cemA:
0.0
2j9cC-1cemA:
undetectable		 2j9cA-1cemA:
16.15
2j9cB-1cemA:
16.15
2j9cC-1cemA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASP A 303
TYR A 282
PHE A 309
LEU A 256
 None
 0.96A 2w98A-1cemA:
undetectable
2w98B-1cemA:
undetectable		 2w98A-1cemA:
21.50
2w98B-1cemA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WB9_A_CYSA301_0
(GLUTATHIONE
TRANSFERASE SIGMA
CLASS)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 5 GLY A  96
ARG A  84
TYR A 371
TYR A 372
 None
 1.40A 2wb9A-1cemA:
2.6		 2wb9A-1cemA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJ8_C_SPMC500_1
(DIAMINE
ACETYLTRANSFERASE 1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 6 ASP A 152
LEU A 199
ASP A 154
LEU A 183
 None
 1.23A 3bj8C-1cemA:
undetectable
3bj8D-1cemA:
0.0		 3bj8C-1cemA:
18.65
3bj8D-1cemA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A 152
ASN A 212
SER A  94
 None
 0.99A 3lslA-1cemA:
0.0
3lslD-1cemA:
0.0		 3lslA-1cemA:
22.70
3lslD-1cemA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_A_NIMA701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		3 / 3 VAL A 340
SER A 344
LEU A 356
 None
 0.76A 3n8xA-1cemA:
0.0		 3n8xA-1cemA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 350
TYR A  41
TRP A 284
GLY A 347
ASP A 349
 None
 0.99A 3ou6D-1cemA:
undetectable		 3ou6D-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 350
TYR A  41
TRP A 284
GLY A 347
ASP A 349
 None
 0.97A 3ou7A-1cemA:
undetectable		 3ou7A-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 LEU A 350
TYR A  41
TRP A 284
GLY A 347
ASP A 349
 None
 0.97A 3ou7D-1cemA:
undetectable		 3ou7D-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WSJ_A_MK1A201_2
(PROTEASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 7 LEU A 183
ASP A 154
ALA A 153
VAL A  82
ILE A 157
 None
 1.14A 3wsjB-1cemA:
0.0		 3wsjB-1cemA:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4POO_B_SAMB301_0
(PUTATIVE RNA
METHYLASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 GLY A 128
HIS A 190
ASP A 203
SER A 122
HIS A 123
 None
 1.39A 4pooB-1cemA:
undetectable		 4pooB-1cemA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QDJ_A_SAMA301_1
(MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 5 HIS A 133
ASP A  85
ASP A 365
TYR A 277
 None
 1.01A 4qdjA-1cemA:
undetectable		 4qdjA-1cemA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.16A 4qvlV-1cemA:
undetectable
4qvlb-1cemA:
undetectable		 4qvlV-1cemA:
18.97
4qvlb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.15A 4qvlH-1cemA:
undetectable
4qvlN-1cemA:
undetectable		 4qvlH-1cemA:
18.97
4qvlN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 4qvmV-1cemA:
undetectable
4qvmb-1cemA:
undetectable		 4qvmV-1cemA:
18.97
4qvmb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 4qvmH-1cemA:
undetectable
4qvmN-1cemA:
undetectable		 4qvmH-1cemA:
18.97
4qvmN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 4qvnV-1cemA:
undetectable
4qvnb-1cemA:
undetectable		 4qvnV-1cemA:
18.97
4qvnb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 4qvnH-1cemA:
undetectable
4qvnN-1cemA:
undetectable		 4qvnH-1cemA:
18.97
4qvnN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.21A 4qvqV-1cemA:
undetectable
4qvqb-1cemA:
undetectable		 4qvqV-1cemA:
18.97
4qvqb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.21A 4qvqH-1cemA:
undetectable
4qvqN-1cemA:
undetectable		 4qvqH-1cemA:
18.97
4qvqN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.17A 4qvwV-1cemA:
undetectable
4qvwb-1cemA:
undetectable		 4qvwV-1cemA:
18.97
4qvwb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.16A 4qvwH-1cemA:
undetectable
4qvwN-1cemA:
undetectable		 4qvwH-1cemA:
18.97
4qvwN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.17A 4qw0V-1cemA:
undetectable
4qw0b-1cemA:
undetectable		 4qw0V-1cemA:
18.97
4qw0b-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.17A 4qw0H-1cemA:
undetectable
4qw0N-1cemA:
undetectable		 4qw0H-1cemA:
18.97
4qw0N-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 4qw1V-1cemA:
undetectable
4qw1b-1cemA:
undetectable		 4qw1V-1cemA:
18.97
4qw1b-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 4qw1H-1cemA:
undetectable
4qw1N-1cemA:
undetectable		 4qw1H-1cemA:
18.97
4qw1N-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 4qw3V-1cemA:
undetectable
4qw3b-1cemA:
undetectable		 4qw3V-1cemA:
18.97
4qw3b-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.19A 4qw3H-1cemA:
undetectable
4qw3N-1cemA:
undetectable		 4qw3H-1cemA:
18.97
4qw3N-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 4qwuV-1cemA:
undetectable
4qwub-1cemA:
undetectable		 4qwuV-1cemA:
18.97
4qwub-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 4qwuH-1cemA:
undetectable
4qwuN-1cemA:
undetectable		 4qwuH-1cemA:
18.97
4qwuN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 5bxnV-1cemA:
undetectable
5bxnb-1cemA:
undetectable		 5bxnV-1cemA:
18.97
5bxnb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 5bxnH-1cemA:
undetectable
5bxnN-1cemA:
undetectable		 5bxnH-1cemA:
18.97
5bxnN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.19A 5cz7H-1cemA:
undetectable
5cz7N-1cemA:
undetectable		 5cz7H-1cemA:
18.97
5cz7N-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.18A 5d0xV-1cemA:
undetectable
5d0xb-1cemA:
undetectable		 5d0xV-1cemA:
18.97
5d0xb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.19A 5d0xH-1cemA:
undetectable
5d0xN-1cemA:
undetectable		 5d0xH-1cemA:
18.97
5d0xN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L2T_A_6ZZA900_2
(CYCLIN-DEPENDENT
KINASE 6)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LYS A  67
GLN A 110
ASN A 108
 None
 1.00A 5l2tA-1cemA:
0.0		 5l2tA-1cemA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.19A 5l5zV-1cemA:
undetectable
5l5zb-1cemA:
undetectable		 5l5zV-1cemA:
18.97
5l5zb-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.19A 5l5zH-1cemA:
undetectable
5l5zN-1cemA:
undetectable		 5l5zH-1cemA:
18.97
5l5zN-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.21A 5l66V-1cemA:
undetectable
5l66b-1cemA:
undetectable		 5l66V-1cemA:
18.97
5l66b-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 11 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 5l66H-1cemA:
undetectable
5l66N-1cemA:
undetectable		 5l66H-1cemA:
18.97
5l66N-1cemA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.16A 5lf3b-1cemA:
undetectable		 5lf3b-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.17A 5lf3N-1cemA:
undetectable		 5lf3N-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_B_6V8B304_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.17A 5lf7V-1cemA:
undetectable
5lf7b-1cemA:
undetectable		 5lf7V-1cemA:
22.63
5lf7b-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF7_N_6V8N305_0
(PROTEASOME SUBUNIT
BETA TYPE-6
PROTEASOME SUBUNIT
BETA TYPE-7)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.17A 5lf7H-1cemA:
undetectable
5lf7N-1cemA:
undetectable		 5lf7H-1cemA:
22.63
5lf7N-1cemA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 10 LEU A 102
GLY A 100
GLY A  96
LEU A 159
ALA A 160
 None
 1.04A 5o96G-1cemA:
undetectable
5o96H-1cemA:
undetectable		 5o96G-1cemA:
20.27
5o96H-1cemA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA601_0
(THIOCYANATE
DEHYDROGENASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		3 / 3 HIS A 133
ASP A 144
HIS A 143
 None
 0.67A 5oexA-1cemA:
undetectable		 5oexA-1cemA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_B_CUB601_0
(THIOCYANATE
DEHYDROGENASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		3 / 3 HIS A 133
ASP A 144
HIS A 143
 None
 0.75A 5oexB-1cemA:
undetectable		 5oexB-1cemA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_C_CUC601_0
(THIOCYANATE
DEHYDROGENASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		3 / 3 HIS A 133
ASP A 144
HIS A 143
 None
 0.78A 5oexC-1cemA:
undetectable		 5oexC-1cemA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_A_SAMA301_1
(METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 4 SER A 375
THR A  92
ASP A 135
ASP A  85
 None
 1.46A 5vimA-1cemA:
undetectable		 5vimA-1cemA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VIM_B_SAMB301_1
(METHYLTRANSFERASE)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		4 / 4 SER A 375
THR A  92
ASP A 135
ASP A  85
 None
 1.49A 5vimB-1cemA:
undetectable		 5vimB-1cemA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_0
(CYTOCHROME P450 1A1)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 SER A 272
ASN A 330
ASP A 274
GLY A 320
ASP A 319
 None
 1.10A 6dwnA-1cemA:
0.0		 6dwnA-1cemA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 6hwdV-1cemA:
undetectable
6hwdb-1cemA:
undetectable		 6hwdV-1cemA:
12.57
6hwdb-1cemA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1cem CELLULASE CELA
(1,4-BETA-D-GLUCAN-G
LUCANOHYDROLASE)
(Ruminiclostridiu
m
thermocellum) 		5 / 12 THR A 280
THR A 306
GLY A 338
ALA A 342
THR A 380
 None
 1.20A 6hwdH-1cemA:
undetectable
6hwdN-1cemA:
undetectable		 6hwdH-1cemA:
12.57
6hwdN-1cemA:
13.14