SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cen'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLN A 140
TYR A 200
PHE A 203
PHE A 320
 BGC  A 351 (-2.8A)
BGC  A 351 (-4.3A)
None
BGC  A 351 ( 4.2A)
 0.95A 1e71M-1cenA:
20.6		 1e71M-1cenA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLN A 140
TYR A 200
PHE A 203
PHE A 320
 BGC  A 351 (-2.8A)
BGC  A 351 (-4.3A)
None
BGC  A 351 ( 4.2A)
 0.91A 1e72M-1cenA:
20.4		 1e72M-1cenA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E73_M_ASCM995_0
(MYROSINASE MA1)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 6 GLN A 140
TYR A 200
PHE A 203
PHE A 320
 BGC  A 351 (-2.8A)
BGC  A 351 (-4.3A)
None
BGC  A 351 ( 4.2A)
 0.95A 1e73M-1cenA:
20.7		 1e73M-1cenA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OBV_A_SAMA501_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-1)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.18A 2obvA-1cenA:
undetectable		 2obvA-1cenA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P02_A_SAMA2_0
(S-ADENOSYLMETHIONINE
SYNTHETASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.12A 2p02A-1cenA:
undetectable		 2p02A-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ARG A  46
GLU A 136
TYR A 200
ASN A 139
HIS A  90
 None
None
BGC  A 351 (-4.3A)
BGC  A 351 (-3.9A)
BGC  A 351 (-4.1A)
 1.44A 3bjmA-1cenA:
undetectable		 3bjmA-1cenA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ARG A  46
GLU A 136
TYR A 200
ASN A 139
HIS A  90
 None
None
BGC  A 351 (-4.3A)
BGC  A 351 (-3.9A)
BGC  A 351 (-4.1A)
 1.45A 3bjmB-1cenA:
undetectable		 3bjmB-1cenA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K2H_B_LYAB514_1
(DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 118
ARG A  46
LEU A  87
ILE A  53
SER A  15
 None
 1.13A 3k2hB-1cenA:
undetectable		 3k2hB-1cenA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_B_ACRB701_1
(ALPHA-GLUCOSIDASE)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ILE A 127
ILE A 171
ILE A 188
ASP A 190
ARG A 161
 None
 1.48A 3phaB-1cenA:
3.3		 3phaB-1cenA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_B_06XB501_1
(CYTOCHROME P450 2B6)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 7 ILE A  29
ILE A  14
GLU A  76
LEU A  85
 None
 0.85A 3ua5B-1cenA:
0.0		 3ua5B-1cenA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 ILE A 337
LEU A 334
VAL A 283
GLY A 282
 None
 0.84A 3w1wA-1cenA:
2.4		 3w1wA-1cenA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W2T_A_LF7A801_1
(DIPEPTIDYL PEPTIDASE
4)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ARG A  46
GLU A 136
TYR A 200
ASN A 139
HIS A  90
 None
None
BGC  A 351 (-4.3A)
BGC  A 351 (-3.9A)
BGC  A 351 (-4.1A)
 1.45A 3w2tA-1cenA:
undetectable		 3w2tA-1cenA:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AX8_A_SAMA1474_0
(WBDD)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A  82
ILE A  37
VAL A  45
HIS A  44
ILE A   8
 None
 0.98A 4ax8A-1cenA:
2.5		 4ax8A-1cenA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_0
(WBDD)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ASN A  82
ILE A  37
VAL A  45
HIS A  44
ILE A   8
 None
 0.98A 4azvA-1cenA:
2.5		 4azvA-1cenA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.21A 4kttA-1cenA:
undetectable		 4kttA-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.11A 4kttC-1cenA:
undetectable		 4kttC-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_A_29QA603_1
(TRANSPORTER)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASP A  43
VAL A  86
ALA A 134
GLY A 309
SER A   3
 None
 1.29A 4mmfA-1cenA:
0.2		 4mmfA-1cenA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMF_B_29QB603_1
(TRANSPORTER)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 9 ASP A  43
VAL A  86
ALA A 134
GLY A 309
SER A   3
 None
 1.24A 4mmfB-1cenA:
undetectable		 4mmfB-1cenA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.18A 4ndnA-1cenA:
undetectable		 4ndnA-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OTW_A_DB8A1101_2
(RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-3)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A 138
LEU A 182
ASN A 175
 None
 0.72A 4otwA-1cenA:
undetectable		 4otwA-1cenA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		3 / 3 LEU A  10
ASP A  88
ILE A 322
 None
 0.55A 4xi3D-1cenA:
0.0		 4xi3D-1cenA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A1I_A_ADNA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.17A 5a1iA-1cenA:
undetectable		 5a1iA-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GLM_A_ACTA613_0
(GLYCOSIDE HYDROLASE
FAMILY 43)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		3 / 3 ASP A  26
SER A  69
TYR A  70
 None
 0.83A 5glmA-1cenA:
undetectable		 5glmA-1cenA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGY_A_ERYA403_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 6 TYR A 277
ILE A 300
TYR A 299
TYR A 200
 None
None
None
BGC  A 351 (-4.3A)
 1.24A 5igyA-1cenA:
undetectable		 5igyA-1cenA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_1
(S-ADENOSYLMETHIONINE
SYNTHASE)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.17A 5t8sB-1cenA:
undetectable		 5t8sB-1cenA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UXD_A_ZITA501_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E MPHH)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 7 GLU A  55
TYR A  63
ALA A  92
GLY A  94
 None
 0.98A 5uxdA-1cenA:
0.0		 5uxdA-1cenA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B1E_B_LF7B801_1
(DIPEPTIDYL PEPTIDASE
4)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		5 / 12 ARG A  46
GLU A 136
TYR A 200
ASN A 139
HIS A  90
 None
None
BGC  A 351 (-4.3A)
BGC  A 351 (-3.9A)
BGC  A 351 (-4.1A)
 1.41A 6b1eB-1cenA:
undetectable		 6b1eB-1cenA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.07A 6fbnB-1cenA:
undetectable		 6fbnB-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBO_A_ADNA406_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.18A 6fboA-1cenA:
undetectable		 6fboA-1cenA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCB_A_SAMA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.20A 6fcbA-1cenA:
undetectable		 6fcbA-1cenA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FCD_A_ADNA405_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)		 1cen CELLULASE CELC
(Ruminiclostridiu
m
thermocellum) 		4 / 8 PRO A  52
SER A  21
PHE A  25
ASP A  50
 None
 1.18A 6fcdA-1cenA:
undetectable		 6fcdA-1cenA:
13.25