SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cf5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 6 LEU A 112
PHE A  83
TYR A 140
VAL A  71
 None
 1.27A 1ibgH-1cf5A:
undetectable		 1ibgH-1cf5A:
20.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRG_A_ADNA300_1
(ALPHA-MOMORCHARIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		7 / 9 PHE A  83
GLY A 107
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
 None
 0.49A 1mrgA-1cf5A:
38.1		 1mrgA-1cf5A:
51.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MRJ_A_ADNA300_1
(ALPHA-TRICHOSANTHIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 8 GLY A 107
TYR A 109
ILE A 153
GLU A 158
ARG A 161
 None
 0.52A 1mrjA-1cf5A:
39.0		 1mrjA-1cf5A:
61.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_G_BEZG513_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 5 PHE A 177
ILE A 184
PRO A 179
GLU A 187
 None
 1.29A 1oniG-1cf5A:
0.0
1oniH-1cf5A:
0.0		 1oniG-1cf5A:
20.08
1oniH-1cf5A:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 7 GLU A 158
GLU A 187
ILE A 183
LEU A 150
 None
 1.43A 1q0yH-1cf5A:
undetectable
1q0yL-1cf5A:
undetectable		 1q0yH-1cf5A:
21.20
1q0yL-1cf5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q0Y_H_MOIH401_1
(FAB 9B1, HEAVY CHAIN
FAB 9B1, LIGHT CHAIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 7 GLU A 158
GLU A 187
ILE A 184
LEU A 150
 None
 1.38A 1q0yH-1cf5A:
undetectable
1q0yL-1cf5A:
undetectable		 1q0yH-1cf5A:
21.20
1q0yL-1cf5A:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TLM_A_MILA128_1
(TRANSTHYRETIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		3 / 3 LEU A 238
LEU A  36
SER A  28
 None
 0.65A 1tlmA-1cf5A:
0.0		 1tlmA-1cf5A:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOF_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 5 LEU A 186
PRO A 216
ALA A 182
ILE A 183
 None
 1.03A 2aofB-1cf5A:
undetectable		 2aofB-1cf5A:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IJ7_C_TPFC2471_1
(CYTOCHROME P450 121)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 8 THR A  24
ASN A  68
PHE A  21
ALA A 157
 None
 1.03A 2ij7C-1cf5A:
0.0		 2ij7C-1cf5A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VUF_A_FUAA2002_1
(SERUM ALBUMIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 9 ILE A 153
PHE A  83
ALA A  73
VAL A  71
 None
 0.79A 2vufA-1cf5A:
undetectable		 2vufA-1cf5A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_A_TPFA1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 10 TYR A  14
ALA A 160
ALA A 157
LEU A 152
VAL A  62
 None
 1.30A 2wuzA-1cf5A:
0.3		 2wuzA-1cf5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WUZ_B_TPFB1460_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE
, PUTATIVE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 10 TYR A  14
ALA A 160
ALA A 157
LEU A 152
VAL A  62
 None
 1.28A 2wuzB-1cf5A:
undetectable		 2wuzB-1cf5A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 6 ASN A 180
TYR A 109
GLU A 158
ILE A 165
 None
 1.14A 3q5sA-1cf5A:
0.0		 3q5sA-1cf5A:
21.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U6T_A_KANA4699_1
(RIBOSOME
INACTIVATING PROTEIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		7 / 10 TYR A  70
ASN A 108
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
 None
 0.75A 3u6tA-1cf5A:
38.2		 3u6tA-1cf5A:
52.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 10 ALA A 157
SER A  61
LEU A  94
VAL A  72
THR A 156
 None
 1.39A 4eilB-1cf5A:
undetectable		 4eilB-1cf5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EIL_B_FOLB703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 10 VAL A  71
SER A  61
LEU A  94
VAL A  72
THR A 156
 None
 1.46A 4eilB-1cf5A:
undetectable		 4eilB-1cf5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 11 ILE A 134
THR A 135
PHE A 138
TYR A 139
ALA A  56
 None
 0.95A 4g1bB-1cf5A:
0.0		 4g1bB-1cf5A:
21.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4JTP_A_ASCA802_0
(RRNA N-GLYCOSIDASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 5 TYR A  70
ASN A 108
TYR A 109
ILE A 153
 None
 0.68A 4jtpA-1cf5A:
38.2		 4jtpA-1cf5A:
52.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_D_FOLD703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 12 ALA A 157
SER A  61
LEU A  94
VAL A  72
THR A 156
 None
 1.41A 4kyaD-1cf5A:
undetectable		 4kyaD-1cf5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 12 ALA A 157
SER A  61
LEU A  94
VAL A  72
THR A 156
 None
 1.42A 4kyaH-1cf5A:
undetectable		 4kyaH-1cf5A:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KYA_H_FOLH703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 12 VAL A  71
SER A  61
LEU A  94
VAL A  72
THR A 156
 None
 1.48A 4kyaH-1cf5A:
undetectable		 4kyaH-1cf5A:
17.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4O0O_A_URFA303_1
(RRNA N-GLYCOSIDASE)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 5 TYR A  70
ASN A 108
TYR A 109
ILE A 153
ARG A 161
 None
 0.68A 4o0oA-1cf5A:
38.3		 4o0oA-1cf5A:
52.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4YP2_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		8 / 9 TYR A  70
PHE A  83
GLY A 107
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
 None
 0.57A 4yp2B-1cf5A:
38.3		 4yp2B-1cf5A:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5CF9_B_NCAB302_0
(RIBOSOME-INACTIVATIN
G PROTEIN MOMORDIN I)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		8 / 9 TYR A  70
PHE A  83
GLY A 107
TYR A 109
ILE A 153
ALA A 157
GLU A 158
ARG A 161
 None
 0.56A 5cf9B-1cf5A:
38.4		 5cf9B-1cf5A:
54.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSH_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 5 ARG A 161
LEU A 237
ASN A  68
VAL A  69
 None
 1.50A 5cshB-1cf5A:
undetectable		 5cshB-1cf5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OS7_B_ACTB401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 5 ARG A 161
LEU A 237
ASN A  68
VAL A  69
 None
 1.50A 5os7B-1cf5A:
undetectable		 5os7B-1cf5A:
20.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 6 TYR A  70
VAL A  71
TYR A 109
GLU A 158
ARG A 161
 None
 0.61A 5z3jA-1cf5A:
34.6		 5z3jA-1cf5A:
37.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		5 / 6 VAL A  71
TYR A 109
ILE A 153
GLU A 158
ARG A 161
 None
 0.58A 5z3jA-1cf5A:
34.6		 5z3jA-1cf5A:
37.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CBD_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 4 VAL A  62
ALA A  73
PHE A  95
PHE A  47
 None
 1.36A 6cbdA-1cf5A:
0.0		 6cbdA-1cf5A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GMD_A_ACTA401_0
(CASEIN KINASE II
SUBUNIT ALPHA)		 1cf5 PROTEIN
(BETA-MOMORCHARIN)
(Momordica
charantia) 		4 / 5 ARG A 161
LEU A 237
ASN A  68
VAL A  69
 None
 1.50A 6gmdA-1cf5A:
undetectable		 6gmdA-1cf5A:
20.69