SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cfr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_C_ADNC603_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 5 THR A 234
GLU A  34
THR A  33
LEU A  73
 None
 1.38A 1d4fC-1cfrA:
undetectable		 1d4fC-1cfrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOM_A_FFOA161_0
(DIHYDROFOLATE
REDUCTASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		5 / 11 ALA A  23
LEU A  42
PHE A  21
ILE A  30
LEU A  73
 None
 1.27A 1jomA-1cfrA:
undetectable		 1jomA-1cfrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		5 / 12 ILE A 164
LEU A  42
PHE A  21
ILE A  30
LEU A  73
 None
 1.22A 1rh3A-1cfrA:
undetectable		 1rh3A-1cfrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		5 / 12 ILE A 164
LEU A  42
PHE A  21
ILE A  30
LEU A  73
 None
 1.15A 1rx3A-1cfrA:
undetectable		 1rx3A-1cfrA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_A_SAMA401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 5 HIS A 203
SER A 206
THR A 249
ASP A 101
 None
 1.43A 3tm4A-1cfrA:
undetectable		 3tm4A-1cfrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_1
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 5 HIS A 203
SER A 206
THR A 249
ASP A 101
 None
 1.41A 3tm4B-1cfrA:
undetectable		 3tm4B-1cfrA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 7 TYR A 230
ILE A  74
ILE A 269
ALA A 232
 None
 0.87A 4lv9A-1cfrA:
undetectable		 4lv9A-1cfrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 7 TYR A 230
ILE A  74
ILE A 269
ALA A 232
 None
 0.85A 4lv9B-1cfrA:
undetectable		 4lv9B-1cfrA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_D_QI9D602_0
(CYTOCHROME P450 2D6)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 7 GLU A  84
SER A 155
VAL A 272
PHE A  81
 None
 1.02A 4wnvD-1cfrA:
0.1		 4wnvD-1cfrA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E72_A_SAMA400_0
(N2,
N2-DIMETHYLGUANOSINE
TRNA
METHYLTRANSFERASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		5 / 12 GLY A  75
ILE A  74
ILE A 183
ASP A 134
PRO A 133
 None
 0.99A 5e72A-1cfrA:
undetectable		 5e72A-1cfrA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_B_CELB602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 6 VAL A  22
SER A  26
ILE A  30
PHE A 156
 None
 0.93A 5jw1B-1cfrA:
0.0		 5jw1B-1cfrA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_A_BEZA301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 7 ILE A 140
LEU A 147
MET A 150
LEU A 151
 None
 0.93A 5u4sA-1cfrA:
3.0		 5u4sA-1cfrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 8 ILE A 140
LEU A 147
MET A 150
LEU A 151
 None
 0.95A 5u4sB-1cfrA:
2.5		 5u4sB-1cfrA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1cfr RESTRICTION
ENDONUCLEASE
(Citrobacter
freundii) 		4 / 5 GLN A 216
THR A 221
HIS A 182
GLY A 226
 None
 1.08A 6gbnC-1cfrA:
undetectable		 6gbnC-1cfrA:
24.71