SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_2
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		3 / 3 LEU A 142
VAL A 145
LEU A 149
 None
 0.46A 1mz9B-1cfzA:
undetectable		 1mz9B-1cfzA:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NP1_A_HSMA303_1
(NITROPHORIN 1)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 5 GLU A  81
LEU A 116
LEU A  77
LEU A 114
 None
 0.85A 1np1A-1cfzA:
0.0		 1np1A-1cfzA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OAX_F_SNLF6001_2
(MINERALOCORTICOID
RECEPTOR)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 5 LEU A 104
LEU A 101
LEU A  95
MET A  52
 None
 0.92A 2oaxF-1cfzA:
0.0		 2oaxF-1cfzA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_B_CHDB502_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 8 ARG A  55
LEU A  58
VAL A   8
GLY A  41
 None
 0.82A 2po5B-1cfzA:
5.4		 2po5B-1cfzA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 ILE A  60
ALA A  61
GLY A   9
GLY A  19
GLY A  41
 None
None
CD  A 163 ( 4.2A)
None
None
 0.87A 2qe6A-1cfzA:
undetectable		 2qe6A-1cfzA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KK6_B_CELB1701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 HIS A  93
VAL A  82
LEU A  85
SER A  91
GLY A 118
 CD  A 163 ( 3.4A)
None
None
CD  A 163 ( 4.3A)
None
 1.12A 3kk6B-1cfzA:
0.0		 3kk6B-1cfzA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LTW_A_HLZA302_1
(ARYLAMINE
N-ACETYLTRANSFERASE
NAT)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 6 LEU A 142
GLU A 139
PRO A 140
ARG A  29
 None
 1.17A 3ltwA-1cfzA:
undetectable		 3ltwA-1cfzA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 VAL A  82
LEU A  48
LEU A  58
GLY A  96
LEU A 101
 None
 1.02A 3n8zA-1cfzA:
undetectable		 3n8zA-1cfzA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_A_CHDA1503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 8 ARG A  55
LEU A  58
VAL A   8
GLY A  41
 None
 0.79A 3w1wA-1cfzA:
4.8		 3w1wA-1cfzA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GRK_A_KTRA713_1
(LACTOTRANSFERRIN)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 5 THR A 133
GLY A  72
VAL A 119
PRO A 121
 None
 1.08A 4grkA-1cfzA:
0.6		 4grkA-1cfzA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_A_DGXA1107_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 ASP A  62
LEU A  97
LEU A  26
GLY A  41
ALA A  44
 CD  A 163 ( 2.4A)
None
None
None
None
 1.18A 4retA-1cfzA:
undetectable		 4retA-1cfzA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 ASP A  62
LEU A  97
LEU A  26
GLY A  41
ALA A  44
 CD  A 163 ( 2.4A)
None
None
None
None
 1.18A 4retC-1cfzA:
undetectable		 4retC-1cfzA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z3O_F_MFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT
B,PARE30-PARC55
FUSED TOPO IV FROM
S. PNEUMONIAE
E-SITE DNA)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 5 ARG A  21
GLY A  19
GLU A  24
SER A  91
 None
None
None
CD  A 163 ( 4.3A)
 1.15A 4z3oA-1cfzA:
3.9
4z3oB-1cfzA:
4.1		 4z3oA-1cfzA:
14.44
4z3oB-1cfzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_0
(PAVINE
N-METHYLTRANSFERASE)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 GLY A   7
GLY A  19
LEU A  26
VAL A   5
LEU A   6
 None
 0.96A 5kpcA-1cfzA:
undetectable		 5kpcA-1cfzA:
18.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_A_SAMA301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 THR A  43
GLY A  19
ALA A 141
ASP A  62
ALA A  61
 None
None
None
CD  A 163 ( 2.4A)
None
 1.13A 5kvaA-1cfzA:
undetectable		 5kvaA-1cfzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KVA_B_SAMB301_0
(CAFFEOYL-COA
O-METHYLTRANSFERASE)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 12 THR A  43
GLY A  19
ALA A 141
ASP A  62
ALA A  61
 None
None
None
CD  A 163 ( 2.4A)
None
 1.15A 5kvaB-1cfzA:
undetectable		 5kvaB-1cfzA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MTH_A_ACTA301_0
(ANTIBODY FAB HEAVY
CHAIN)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		4 / 4 THR A 131
VAL A 134
PRO A  71
THR A 133
 None
 1.32A 5mthA-1cfzA:
0.0
5mthH-1cfzA:
0.0		 5mthA-1cfzA:
25.94
5mthH-1cfzA:
25.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CZM_B_HISB402_0
(ATP
PHOSPHORIBOSYLTRANSF
ERASE CATALYTIC
SUBUNIT)		 1cfz HYDROGENASE 2
MATURATION PROTEASE
(Escherichia
coli) 		5 / 9 VAL A  23
VAL A 117
LEU A  26
LEU A 146
GLN A 144
 None
 1.31A 6czmA-1cfzA:
0.6
6czmB-1cfzA:
0.0		 6czmA-1cfzA:
23.01
6czmB-1cfzA:
23.01