SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 VAL A   4
TYR A 261
VAL A 262
SER A 323
LEU A   7
 None
 0.98A 1igxA-1cg4A:
undetectable		 1igxA-1cg4A:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KT3_A_RTLA184_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 LEU A 146
LEU A 151
MET A  80
LEU A 187
 None
 1.09A 1kt3A-1cg4A:
0.0		 1kt3A-1cg4A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KYV_D_RBFD504_1
(6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 LEU A  97
GLY A  58
SER A  57
LEU A  52
ILE A  55
 None
 1.21A 1kyvC-1cg4A:
undetectable
1kyvD-1cg4A:
undetectable		 1kyvC-1cg4A:
17.50
1kyvD-1cg4A:
17.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MF1_A_ACTA458_0
(ADENYLOSUCCINATE
SYNTHETASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 4 GLY A  15
LYS A  16
GLY A  17
HIS A  41
 GDP  A 432 (-3.3A)
IMO  A 440 ( 2.9A)
GDP  A 432 (-3.6A)
GDP  A 432 (-3.6A)
 0.32A 1mf1A-1cg4A:
57.4		 1mf1A-1cg4A:
42.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OPJ_A_STIA3_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 TYR A  33
VAL A  51
ILE A  55
MET A 219
 None
 1.29A 1opjA-1cg4A:
0.0		 1opjA-1cg4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_ACTA860_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 GLY A 247
GLN A  34
VAL A   5
ALA A 245
 None
 1.03A 1p6kA-1cg4A:
0.0		 1p6kA-1cg4A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RH3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 LEU A  43
SER A  66
ILE A  59
LEU A  86
ARG A  89
 None
 1.33A 1rh3A-1cg4A:
2.5		 1rh3A-1cg4A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B25_B_SAMB602_0
(HYPOTHETICAL PROTEIN)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 251
SER A 252
GLY A  69
ASP A 231
ILE A 230
 None
 1.10A 2b25B-1cg4A:
undetectable		 2b25B-1cg4A:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_A_CLMA1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 GLY A 264
ILE A 410
GLY A 326
TYR A 261
 None
 0.87A 2jkjA-1cg4A:
0.0		 2jkjA-1cg4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_B_CLMB1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 GLY A 264
ILE A 410
GLY A 326
TYR A 261
 None
 0.87A 2jkjB-1cg4A:
undetectable		 2jkjB-1cg4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKJ_C_CLMC1141_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 GLY A 264
ILE A 410
GLY A 326
TYR A 261
 None
 0.86A 2jkjC-1cg4A:
undetectable		 2jkjC-1cg4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JKL_B_CLMB1144_0
(DR HEMAGGLUTININ
STRUCTURAL SUBUNIT)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 GLY A 264
ILE A 410
GLY A 326
TYR A 261
 None
 0.86A 2jklB-1cg4A:
undetectable		 2jklB-1cg4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NMZ_B_ROCB401_2
(PROTEASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 272
VAL A 313
THR A 358
 None
 0.82A 2nmzA-1cg4A:
0.0		 2nmzA-1cg4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNK_A_ROCA401_2
(PROTEASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 272
VAL A 313
THR A 358
 None
 0.87A 2nnkA-1cg4A:
undetectable		 2nnkA-1cg4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VN0_A_TDZA501_1
(CYTOCHROME P450 2C8)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ILE A  68
LEU A  79
VAL A  72
VAL A 148
ILE A 196
 None
 1.04A 2vn0A-1cg4A:
0.0		 2vn0A-1cg4A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 GLY A 264
VAL A 319
ALA A 318
LEU A 310
THR A 406
 None
 1.07A 3a3yA-1cg4A:
undetectable		 3a3yA-1cg4A:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
 None
 0.85A 3c6gA-1cg4A:
0.0		 3c6gA-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
 None
 0.81A 3c6gB-1cg4A:
undetectable		 3c6gB-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 LEU A 329
ALA A 394
THR A 406
VAL A 315
THR A 312
 None
 0.84A 3czhB-1cg4A:
0.0		 3czhB-1cg4A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H52_C_486C4_2
(GLUCOCORTICOID
RECEPTOR)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 MET A 349
CYH A 344
PRO A 279
 None
 1.18A 3h52C-1cg4A:
0.0		 3h52C-1cg4A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K4V_B_ROCB201_2
(HIV-1 PROTEASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 272
VAL A 313
THR A 358
 None
 0.84A 3k4vA-1cg4A:
0.0		 3k4vA-1cg4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K5V_A_STIA2_2
(TYROSINE-PROTEIN
KINASE ABL1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 LEU A 391
VAL A 345
VAL A 341
ILE A 402
 None
 1.16A 3k5vA-1cg4A:
undetectable		 3k5vA-1cg4A:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 251
GLY A 247
ASN A 242
ALA A 102
LEU A 254
 None
 0.94A 3p2kC-1cg4A:
undetectable		 3p2kC-1cg4A:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWR_A_ROCA401_2
(PROTEASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 272
VAL A 313
THR A 358
 None
 0.82A 3pwrA-1cg4A:
undetectable		 3pwrA-1cg4A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q1E_D_T44D328_1
(5-HYDROXYISOURATE
HYDROLASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 LEU A 197
THR A 190
LEU A 107
HIS A  37
LEU A 105
 None
 1.27A 3q1eB-1cg4A:
0.0
3q1eD-1cg4A:
0.0		 3q1eB-1cg4A:
13.98
3q1eD-1cg4A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TL9_A_ROCA401_2
(PROTEASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 272
VAL A 313
THR A 358
 None
 0.85A 3tl9A-1cg4A:
0.0		 3tl9A-1cg4A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_E_ACTE503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 GLN A 224
THR A 300
ASN A  38
 IMO  A 440 (-3.6A)
None
IMO  A 440 (-4.0A)
 0.72A 3v4tE-1cg4A:
0.0		 3v4tE-1cg4A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LZR_A_LOCA201_1
(BROMODOMAIN-CONTAINI
NG PROTEIN 4)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 VAL A  72
LEU A  74
LEU A  54
ASN A  38
ILE A 133
 None
None
None
IMO  A 440 (-4.0A)
IMO  A 440 ( 4.4A)
 1.47A 4lzrA-1cg4A:
undetectable		 4lzrA-1cg4A:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 VAL A  93
LEU A  97
ARG A  96
LEU A  52
 None
 0.96A 4o1zA-1cg4A:
undetectable		 4o1zA-1cg4A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OBW_C_SAMC601_0
(2-METHOXY-6-POLYPREN
YL-1,4-BENZOQUINOL
METHYLASE,
MITOCHONDRIAL)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ASN A  38
GLY A 225
ILE A 265
GLY A 264
ARG A  32
 IMO  A 440 (-4.0A)
None
None
None
None
 1.19A 4obwC-1cg4A:
2.3		 4obwC-1cg4A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_A_HFGA803_0
(PROLINE--TRNA LIGASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
GLY A 287
 None
 1.18A 4q15A-1cg4A:
undetectable		 4q15A-1cg4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q15_B_HFGB803_0
(PROLINE--TRNA LIGASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
GLY A 287
 None
 1.21A 4q15B-1cg4A:
undetectable		 4q15B-1cg4A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 ILE A 133
GLN A 224
ILE A 230
ASP A 229
 IMO  A 440 ( 4.4A)
IMO  A 440 (-3.6A)
None
None
 1.00A 4w5tA-1cg4A:
0.0		 4w5tA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4C_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 ILE A 133
GLN A 224
ILE A 230
ASP A 229
 IMO  A 440 ( 4.4A)
IMO  A 440 (-3.6A)
None
None
 1.02A 4z4cA-1cg4A:
undetectable		 4z4cA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EHG_C_SAMC4001_0
(RNA-DIRECTED RNA
POLYMERASE NS5)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A  12
GLY A  35
GLY A 225
GLU A 221
VAL A  73
 IMO  A 440 (-2.7A)
None
None
None
None
 0.90A 5ehgC-1cg4A:
undetectable		 5ehgC-1cg4A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I73_A_68PA701_1
(SODIUM-DEPENDENT
SEROTONIN
TRANSPORTER)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ASP A 411
ILE A 402
GLY A 264
LEU A 332
VAL A 315
 None
 0.83A 5i73A-1cg4A:
0.0		 5i73A-1cg4A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OY0_1_PQN1842_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT IX)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 10 PHE A 289
LEU A 290
GLY A 287
ILE A 399
LEU A 396
 None
 1.22A 5oy01-1cg4A:
undetectable
5oy07-1cg4A:
0.0		 5oy01-1cg4A:
13.70
5oy07-1cg4A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WEA_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 LEU A 335
LYS A 331
LEU A 290
GLU A 296
 None
GDP  A 432 (-3.0A)
None
None
 1.27A 5weaA-1cg4A:
1.7		 5weaA-1cg4A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
GLY A 287
 None
 1.16A 5xipA-1cg4A:
undetectable		 5xipA-1cg4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_A_HFGA1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 VAL A 368
PRO A 279
THR A 280
THR A 286
GLY A 287
 None
 1.29A 5xipA-1cg4A:
undetectable		 5xipA-1cg4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_B_HFGB1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
THR A 286
 None
 1.38A 5xipB-1cg4A:
undetectable		 5xipB-1cg4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_C_HFGC1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		6 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
THR A 286
GLY A 287
 None
 1.35A 5xipC-1cg4A:
undetectable		 5xipC-1cg4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIP_D_HFGD1003_0
(PROLYL-TRNA
SYNTHETASE, PUTATIVE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
THR A 286
 None
 1.27A 5xipD-1cg4A:
undetectable		 5xipD-1cg4A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_A_HFGA1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 286
GLY A 287
 None
 1.09A 5xiqA-1cg4A:
undetectable		 5xiqA-1cg4A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_C_HFGC1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 280
THR A 286
 None
 1.26A 5xiqC-1cg4A:
undetectable		 5xiqC-1cg4A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XIQ_D_HFGD1002_0
(PROLYL-TRNA
SYNTHETASE (PRORS))		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLU A 369
VAL A 368
PRO A 279
THR A 286
GLY A 287
 None
 1.06A 5xiqD-1cg4A:
undetectable		 5xiqD-1cg4A:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XPR_A_K86A1201_1
(ENDOTHELIN B
RECEPTOR,ENDOLYSIN,E
NDOTHELIN B RECEPTOR)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 VAL A 341
TRP A 378
LEU A 332
ILE A 399
ALA A 395
 None
 1.27A 5xprA-1cg4A:
0.2		 5xprA-1cg4A:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 VAL A 262
VAL A 259
GLY A  71
VAL A  72
PRO A  56
 None
 1.10A 6brdC-1cg4A:
undetectable		 6brdC-1cg4A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CNJ_D_NCTD402_1
(NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4
NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
BETA-2)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 TYR A 398
THR A 330
TYR A 269
TRP A 378
 None
 1.47A 6cnjD-1cg4A:
0.0
6cnjE-1cg4A:
undetectable		 6cnjD-1cg4A:
13.14
6cnjE-1cg4A:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F6S_A_CXQA507_1
(ENVELOPE
GLYCOPROTEIN,ENVELOP
E GLYCOPROTEIN,GP1
ENVELOPE
GLYCOPROTEIN)		 1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 ARG A 117
ALA A 112
TYR A 109
ILE A 106
 None
 1.24A 6f6sA-1cg4A:
0.0
6f6sB-1cg4A:
0.0		 6f6sA-1cg4A:
11.25
6f6sB-1cg4A:
11.84