SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cg8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FM6_U_9CRU502_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		5 / 12 LEU B  28
ALA B  25
VAL B  93
ILE B  91
LEU B  84
 None
None
HEM  B 142 ( 4.6A)
HEM  B 142 (-4.3A)
HEM  B 142 (-4.6A)
 0.98A 1fm6U-1cg8B:
undetectable		 1fm6U-1cg8B:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		4 / 7 PHE A  43
PHE A  46
VAL A  63
HIS A  88
 HEM  A 142 (-3.9A)
None
HEM  A 142 (-4.0A)
HEM  A 142 ( 3.3A)
 0.92A 1lh6A-1cg8A:
13.7		 1lh6A-1cg8A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MZ9_D_VDYD1001_5
(CARTILAGE OLIGOMERIC
MATRIX PROTEIN)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 THR B  24
LEU B  28
VAL B  31
 None
 0.67A 1mz9E-1cg8B:
undetectable		 1mz9E-1cg8B:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XPQ_D_SPMD922_1
(FMS1 PROTEIN)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		5 / 10 TRP B  15
ASP B  72
LEU B 109
PHE B 128
TYR B 113
 None
 1.43A 1xpqD-1cg8B:
undetectable		 1xpqD-1cg8B:
14.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2001_1
(SERUM ALBUMIN)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		5 / 11 LEU A  16
ILE A  17
ASN A  20
GLY A  25
LEU A 110
 None
 1.08A 2bxeA-1cg8A:
2.0		 2bxeA-1cg8A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_A_ACRA5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 LEU B   3
TRP B  15
TYR B  10
 None
 0.92A 3aicA-1cg8B:
undetectable		 3aicA-1cg8B:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_B_ACRB5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 LEU B   3
TRP B  15
TYR B  10
 None
 0.95A 3aicB-1cg8B:
undetectable		 3aicB-1cg8B:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_E_ACRE5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 LEU B   3
TRP B  15
TYR B  10
 None
 0.95A 3aicE-1cg8B:
undetectable		 3aicE-1cg8B:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_F_ACRF5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 LEU B   3
TRP B  15
TYR B  10
 None
 0.92A 3aicF-1cg8B:
undetectable		 3aicF-1cg8B:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_G_ACRG5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 LEU B   3
TRP B  15
TYR B  10
 None
 0.94A 3aicG-1cg8B:
undetectable		 3aicG-1cg8B:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AIC_H_ACRH5044_2
(GLUCOSYLTRANSFERASE-
SI)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		3 / 3 LEU B   3
TRP B  15
TYR B  10
 None
 0.95A 3aicH-1cg8B:
undetectable		 3aicH-1cg8B:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OAP_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		5 / 12 LEU B  28
ALA B  25
VAL B  93
ILE B  91
LEU B  84
 None
None
HEM  B 142 ( 4.6A)
HEM  B 142 (-4.3A)
HEM  B 142 (-4.6A)
 0.92A 3oapA-1cg8B:
undetectable		 3oapA-1cg8B:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T44A501_1
(THYROID HORMONE
RECEPTOR ALPHA)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		4 / 6 SER A   3
GLN A   5
VAL A 120
THR A 121
 None
 1.27A 4lnxA-1cg8A:
0.5		 4lnxA-1cg8A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_C_PCFC607_0
(CYTOCHROME B)		 1cg8 PROTEIN (HEMOGLOBIN)
(Dasyatis
akajei) 		5 / 10 TRP B  15
ALA B  70
PHE B 128
PHE B 129
VAL B 132
 None
 1.24A 6hu9C-1cg8B:
0.9		 6hu9C-1cg8B:
16.62