SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ch4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LH6_A_NIOA155_1
(LEGHEMOGLOBIN A
(NICOTINATE MET))		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 7 PHE A  42
PHE A  45
VAL A  67
HIS A  92
 HEM  A 147 (-4.2A)
HEM  A 147 (-4.7A)
HEM  A 147 (-4.2A)
HEM  A 147 (-3.3A)
 0.80A 1lh6A-1ch4A:
13.6		 1lh6A-1ch4A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SN5_D_T3D602_1
(TRANSTHYRETIN)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		5 / 12 LEU A  68
VAL A 133
LEU A 130
LEU A 111
VAL A  20
 None
 1.14A 1sn5B-1ch4A:
undetectable
1sn5D-1ch4A:
undetectable		 1sn5B-1ch4A:
24.38
1sn5D-1ch4A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_1
(MINERALOCORTICOID
RECEPTOR)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A 135
SER A 129
LEU A 130
LEU A   3
 None
 1.25A 1ya3B-1ch4A:
1.0		 1ya3B-1ch4A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_D_D16D609_1
(THYMIDYLATE SYNTHASE)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		5 / 9 ASP A  47
LEU A  48
GLY A  46
PHE A  45
THR A  38
 None
None
None
HEM  A 147 (-4.7A)
HEM  A 147 ( 4.7A)
 1.33A 2tsrD-1ch4A:
undetectable		 2tsrD-1ch4A:
18.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 8 LEU A  68
VAL A  67
VAL A 137
LEU A 134
 None
HEM  A 147 (-4.2A)
None
None
 0.74A 2zujA-1ch4A:
undetectable		 2zujA-1ch4A:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IFX_A_ACTA404_0
(THIAMINE
BIOSYNTHESIS
LIPOPROTEIN APBE)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 5 SER A 107
LYS A 104
LEU A 134
ASP A 131
 None
 1.02A 4ifxA-1ch4A:
undetectable		 4ifxA-1ch4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IG1_A_ACTA504_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 5 SER A 107
LYS A 104
LEU A 134
ASP A 131
 None
 1.03A 4ig1A-1ch4A:
undetectable		 4ig1A-1ch4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		5 / 10 LEU A 114
LEU A  14
VAL A 133
LEU A   3
LEU A  78
 None
 1.20A 4po0A-1ch4A:
2.5		 4po0A-1ch4A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XDT_A_ACTA406_0
(FAD:PROTEIN FMN
TRANSFERASE)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 5 SER A 107
LYS A 104
LEU A 134
ASP A 131
 None
 1.02A 4xdtA-1ch4A:
0.0		 4xdtA-1ch4A:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		5 / 12 LEU A  81
ALA A 135
SER A 129
LEU A 130
LEU A   3
 None
 1.09A 5mwyA-1ch4A:
undetectable		 5mwyA-1ch4A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NOO_C_D16C402_1
(THYMIDYLATE SYNTHASE)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 6 ASP A  47
LEU A  48
GLY A  46
PHE A  45
 None
None
None
HEM  A 147 (-4.7A)
 0.99A 5nooC-1ch4A:
undetectable		 5nooC-1ch4A:
20.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 8 PRO A 100
LYS A 104
THR A 142
TYR A 145
 None
 1.13A 5x2sI-1ch4A:
21.5
5x2sJ-1ch4A:
25.4
5x2sK-1ch4A:
21.6		 5x2sI-1ch4A:
60.81
5x2sJ-1ch4A:
82.19
5x2sK-1ch4A:
60.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2S_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 8 PRO A 100
THR A 139
THR A 142
TYR A 145
 None
 0.61A 5x2sI-1ch4A:
21.5
5x2sJ-1ch4A:
25.4
5x2sK-1ch4A:
21.6		 5x2sI-1ch4A:
60.81
5x2sJ-1ch4A:
82.19
5x2sK-1ch4A:
60.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5X2T_I_PEMI202_1
(HEMOGLOBIN SUBUNIT
ALPHA
HEMOGLOBIN SUBUNIT
BETA)		 1ch4 MODULE-SUBSTITUTED
CHIMERA HEMOGLOBIN
BETA-ALPHA
(Homo
sapiens) 		4 / 8 PRO A 100
ALA A 135
THR A 139
THR A 142
 None
 0.27A 5x2tI-1ch4A:
21.7
5x2tJ-1ch4A:
25.4
5x2tK-1ch4A:
21.9
5x2tL-1ch4A:
24.1		 5x2tI-1ch4A:
60.81
5x2tJ-1ch4A:
82.19
5x2tK-1ch4A:
60.81
5x2tL-1ch4A:
82.19