SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1chd'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 277
VAL A 174
LEU A 280
LEU A 158
LEU A 175
 None
 0.92A 1ya4C-1chdA:
2.2		 1ya4C-1chdA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRD_A_MIYA2001_1
(ACRB)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 9 GLY A 323
ASN A 320
ILE A 319
ALA A 303
VAL A 327
 None
 1.36A 2drdA-1chdA:
0.0		 2drdA-1chdA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J5M_A_ACTA1321_0
(CHLOROPEROXIDASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 6 LEU A 175
PHE A 199
ILE A 227
ALA A 225
 None
 1.01A 2j5mA-1chdA:
0.0		 2j5mA-1chdA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 5 ASP A 216
ILE A 186
ILE A 247
GLY A 217
 None
 0.93A 3bufA-1chdA:
undetectable		 3bufA-1chdA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A99_C_MIYC392_1
(TETX2 PROTEIN)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 PRO A 229
GLU A 213
VAL A 220
ILE A 245
TYR A 226
 None
 1.38A 4a99A-1chdA:
undetectable
4a99C-1chdA:
undetectable		 4a99A-1chdA:
20.19
4a99C-1chdA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F84_A_SAMA501_0
(GERANYL DIPHOSPHATE
2-C-METHYLTRANSFERAS
E)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 12 GLY A 282
GLY A 166
THR A 281
MET A 314
VAL A 260
 None
 1.23A 4f84A-1chdA:
undetectable		 4f84A-1chdA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		5 / 9 VAL A 324
ILE A 187
ALA A 163
THR A 281
ALA A 303
 None
 1.18A 4oqrA-1chdA:
undetectable		 4oqrA-1chdA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_C_ADNC501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		3 / 3 PRO A 251
VAL A 262
HIS A 265
 None
 0.85A 4pevC-1chdA:
2.3		 4pevC-1chdA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R20_A_AERA602_1
(CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 ALA A 228
GLY A 162
VAL A 267
SER A 266
 None
 0.73A 4r20A-1chdA:
undetectable		 4r20A-1chdA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZDZ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.81A 4zdzA-1chdA:
undetectable		 4zdzA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE3_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.84A 4ze3A-1chdA:
undetectable		 4ze3A-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.85A 5eseA-1chdA:
undetectable		 5eseA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESF_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.84A 5esfA-1chdA:
0.0		 5esfA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESJ_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.83A 5esjA-1chdA:
undetectable		 5esjA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESM_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 7 PHE A 199
GLY A 167
THR A 281
LEU A 330
 None
 0.83A 5esmA-1chdA:
undetectable		 5esmA-1chdA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA608_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		3 / 3 GLY A 194
THR A 196
GLU A 213
 None
 0.50A 6b58A-1chdA:
undetectable		 6b58A-1chdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 1chd CHEB METHYLESTERASE
(Salmonella
enterica) 		4 / 8 LEU A 330
VAL A 278
LEU A 280
ILE A 161
 None
 0.82A 6cb4A-1chdA:
undetectable		 6cb4A-1chdA:
17.33