SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1chk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A28_B_STRB2_1
(PROGESTERONE
RECEPTOR)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		5 / 12 LEU A 221
LEU A 138
ASN A 218
LEU A 214
LEU A  17
 None
 1.32A 1a28B-1chkA:
undetectable		 1a28B-1chkA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 8 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.56A 1d0vA-1chkA:
undetectable		 1d0vA-1chkA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 6 LYS A  10
LYS A  11
ALA A  14
VAL A 127
 None
 0.68A 1hk1A-1chkA:
0.0		 1hk1A-1chkA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3003_1
(SERUM ALBUMIN)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 6 PHE A 141
LYS A  10
LYS A  11
ALA A  14
 None
 0.64A 1hk2A-1chkA:
0.0		 1hk2A-1chkA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHA_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 8 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.60A 1jhaA-1chkA:
undetectable		 1jhaA-1chkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 8 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.53A 1jhqA-1chkA:
undetectable		 1jhqA-1chkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 8 GLY A 139
GLY A 185
PHE A 186
LEU A 187
 None
 0.56A 1jhvA-1chkA:
undetectable		 1jhvA-1chkA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 8 GLU A  22
VAL A 148
GLU A 209
ASP A 145
 None
 1.09A 1s3zA-1chkA:
undetectable
1s3zB-1chkA:
undetectable		 1s3zA-1chkA:
22.49
1s3zB-1chkA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA503_0
(CHORISMATE SYNTHASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 5 GLN A 175
THR A 172
ARG A 171
ALA A 170
 None
 1.17A 2qhfA-1chkA:
0.0		 2qhfA-1chkA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3K37_B_BCZB468_1
(NEURAMINIDASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		3 / 3 ARG A 190
GLU A 209
TYR A 230
 None
 0.89A 3k37B-1chkA:
0.0		 3k37B-1chkA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_G_PZIG800_0
(GLUTAMATE RECEPTOR 2)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 6 ASN A 184
LEU A 187
ASP A 188
LYS A 191
 None
 1.08A 3lslG-1chkA:
undetectable		 3lslG-1chkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q5S_A_ACHA1289_0
(MULTIDRUG-EFFLUX
TRANSPORTER 1
REGULATOR)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 6 VAL A  18
ASN A  23
TYR A 144
ILE A  48
 None
 0.95A 3q5sA-1chkA:
0.0		 3q5sA-1chkA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 8 PHE A 141
ASP A 145
ALA A  21
SER A  20
 None
 1.05A 4lv9A-1chkA:
0.0
4lv9B-1chkA:
0.0		 4lv9A-1chkA:
19.04
4lv9B-1chkA:
19.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB601_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 7 PHE A 141
ASP A 145
ALA A  21
SER A  20
 None
 1.06A 4lv9A-1chkA:
undetectable
4lv9B-1chkA:
undetectable		 4lv9A-1chkA:
19.04
4lv9B-1chkA:
19.04
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4QWP_A_GCSA301_1
(CHITOSANASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		3 / 3 TYR A 122
GLY A 151
PRO A 152
 None
 0.18A 4qwpA-1chkA:
34.3		 4qwpA-1chkA:
60.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TJY_A_BEZA304_0
(4-HYDROXY-TETRAHYDRO
DIPICOLINATE
REDUCTASE)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		3 / 3 MET A 194
GLU A 209
ARG A 205
 None
 1.12A 5tjyA-1chkA:
undetectable		 5tjyA-1chkA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		5 / 12 LEU A  81
GLY A  47
PHE A  97
ALA A  88
GLY A  50
 None
 1.07A 5veuH-1chkA:
0.0		 5veuH-1chkA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 1chk CHITOSANASE
(Streptomyces
sp.
N174) 		4 / 5 THR A  45
ARG A  42
GLN A 114
ASP A  27
 None
 1.49A 6ectA-1chkA:
undetectable		 6ectA-1chkA:
20.00