SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1chm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HRK_A_CHDA1503_0
(FERROCHELATASE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		3 / 3 LEU A 363
PRO A 364
LEU A 367
 None
 0.55A 1hrkA-1chmA:
undetectable		 1hrkA-1chmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		4 / 7 LEU A 265
THR A 220
LEU A 246
SER A 224
 None
 0.99A 1tyrB-1chmA:
0.0		 1tyrB-1chmA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		4 / 6 SER A 325
GLY A 327
THR A 328
ARG A 156
 None
 1.23A 2f7fA-1chmA:
undetectable		 2f7fA-1chmA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		4 / 7 GLU A 144
ILE A  40
ALA A 114
ILE A  76
 None
 0.84A 2xkwA-1chmA:
undetectable		 2xkwA-1chmA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		5 / 12 ILE A  44
GLN A 112
LEU A 115
VAL A 148
LEU A 128
 None
 0.95A 3dzuA-1chmA:
undetectable		 3dzuA-1chmA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HCR_A_CHDA4_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		3 / 3 LEU A 367
PRO A 368
LEU A 363
 None
 0.47A 3hcrA-1chmA:
0.0		 3hcrA-1chmA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU1_G_SAMG226_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		5 / 12 LEU A  31
ALA A  43
GLY A 122
LEU A 136
ILE A 111
 None
 1.15A 3ku1G-1chmA:
undetectable		 3ku1G-1chmA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KU9_B_SPMB700_1
(POLYAMINE OXIDASE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		4 / 7 TYR A  54
TYR A  53
GLU A  23
TYR A 257
 None
 1.36A 3ku9B-1chmA:
undetectable		 3ku9B-1chmA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KW2_B_ADNB300_1
(PROBABLE R-RNA
METHYLTRANSFERASE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		5 / 11 ALA A  42
VAL A  70
ILE A 121
GLY A 122
LEU A 115
 None
 1.17A 3kw2B-1chmA:
undetectable		 3kw2B-1chmA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W1W_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		3 / 3 LEU A 363
PRO A 364
LEU A 367
 None
 0.49A 3w1wB-1chmA:
undetectable		 3w1wB-1chmA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_A_ACTA504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		3 / 3 ARG A 263
TRP A 278
GLY A 395
 None
 1.02A 4e7cA-1chmA:
0.0		 4e7cA-1chmA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L64_A_C2FA802_0
(5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		4 / 7 SER A  79
TYR A  66
ARG A  64
VAL A  98
 None
 1.22A 4l64A-1chmA:
0.7		 4l64A-1chmA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		4 / 5 ILE A 380
LEU A 329
GLY A 327
PHE A 326
 None
 0.83A 5kmdC-1chmA:
0.0
5kmdD-1chmA:
0.0		 5kmdC-1chmA:
21.98
5kmdD-1chmA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUM_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		5 / 8 ILE A  44
LEU A 136
ILE A 111
ILE A  78
SER A  61
 None
 1.26A 5numA-1chmA:
0.0		 5numA-1chmA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y2T_A_8LXA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1chm CREATINE
AMIDINOHYDROLASE
(Pseudomonas
putida) 		3 / 3 SER A 356
HIS A 324
TYR A 258
 None
CMS  A 404 (-4.5A)
None
 0.92A 5y2tA-1chmA:
0.0		 5y2tA-1chmA:
undetectable