SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ci9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		3 / 3 VAL A 191
VAL A  85
TRP A 103
 None
 1.00A 1av2A-1ci9A:
undetectable
1av2B-1ci9A:
undetectable		 1av2A-1ci9A:
8.97
1av2B-1ci9A:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1F86_B_T44B528_1
(TRANSTHYRETIN
THR119MET VARIANT)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 4 LYS A  78
LEU A 185
ALA A  82
LEU A 188
 DFP  A 401 ( 4.2A)
None
None
None
 1.37A 1f86B-1ci9A:
0.0		 1f86B-1ci9A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		3 / 3 PHE A 107
LEU A 131
LEU A 171
 None
 0.61A 1mx1E-1ci9A:
undetectable		 1mx1E-1ci9A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 PHE A 173
LEU A 124
VAL A 187
PHE A 107
VAL A 119
 None
 1.35A 1q23C-1ci9A:
0.1		 1q23C-1ci9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 10 TYR A 143
LEU A 124
VAL A 187
PHE A 107
VAL A 119
 None
 1.43A 1q23K-1ci9A:
0.3		 1q23K-1ci9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 11 PHE A 173
LEU A 124
VAL A 187
PHE A 107
VAL A 119
 None
 1.38A 1q23L-1ci9A:
0.1		 1q23L-1ci9A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_A_9CRA500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 ALA A 306
GLN A 310
ALA A 305
VAL A 192
LEU A 185
 None
 1.12A 1xdkA-1ci9A:
undetectable		 1xdkA-1ci9A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		3 / 3 ARG A 240
VAL A 264
GLY A 279
 None
 0.60A 2avvE-1ci9A:
0.0		 2avvE-1ci9A:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_C_VIAC903_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 LEU A 302
LEU A  96
ALA A  98
ILE A 121
LEU A 207
 None
 0.97A 2h42C-1ci9A:
0.0		 2h42C-1ci9A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1414_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 8 MET A  65
LEU A 381
LEU A  35
THR A 370
LEU A 368
 None
 1.40A 2xfhA-1ci9A:
0.0		 2xfhA-1ci9A:
24.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		6 / 9 ALA A 203
VAL A 192
GLY A 189
GLY A 273
LEU A 207
ALA A  84
 None
 1.44A 2z0yA-1ci9A:
undetectable		 2z0yA-1ci9A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Z0Y_A_SAMA300_0
(PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0657)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		6 / 9 ALA A 203
VAL A 192
GLY A 189
GLY A 273
LEU A 207
ILE A  80
 None
 1.32A 2z0yA-1ci9A:
undetectable		 2z0yA-1ci9A:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZI9_A_CL9A401_2
(DEOXYCYTIDINE KINASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		3 / 3 ASP A  23
PHE A  26
LEU A  30
 None
 0.42A 2zi9A-1ci9A:
undetectable		 2zi9A-1ci9A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
 None
 1.02A 3c6gA-1ci9A:
0.0		 3c6gA-1ci9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_B_VD3B700_1
(CYTOCHROME P450 2R1)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
 None
 1.02A 3c6gB-1ci9A:
0.0		 3c6gB-1ci9A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 LEU A  30
ALA A  40
ALA A 388
THR A 372
THR A 370
 None
 1.07A 3czhB-1ci9A:
0.0		 3czhB-1ci9A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 7 ILE A 152
PHE A 227
PHE A 265
GLY A 244
 None
 1.11A 3em0B-1ci9A:
0.3		 3em0B-1ci9A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWU_A_SREA801_1
(TRANSPORTER)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 LEU A 327
GLN A 310
PHE A 324
LEU A 188
THR A 128
 None
 1.29A 3gwuA-1ci9A:
0.0		 3gwuA-1ci9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 6 PHE A 357
TYR A 390
HIS A 342
THR A 345
 None
 1.31A 3lb3B-1ci9A:
0.0		 3lb3B-1ci9A:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SO9_A_017A100_2
(HIV-1 PROTEASE)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 LEU A 135
VAL A 247
GLY A 353
PRO A 250
VAL A 257
 DFP  A 401 (-4.3A)
None
None
None
None
 0.90A 3so9B-1ci9A:
undetectable		 3so9B-1ci9A:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_B_ADNB401_1
(APH(2'')-ID)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 10 SER A 272
GLY A 274
ALA A 275
ILE A 148
LEU A 166
 None
None
DFP  A 401 (-3.2A)
None
None
 1.05A 4dt8B-1ci9A:
undetectable		 4dt8B-1ci9A:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB8_A_DXCA75_0
(PPCA)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 8 LEU A 367
LYS A  78
ILE A  80
GLY A 350
 None
DFP  A 401 ( 4.2A)
None
DFP  A 401 (-3.3A)
 0.83A 4hb8A-1ci9A:
undetectable		 4hb8A-1ci9A:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 6 LEU A 131
LEU A 163
PHE A 219
MET A 277
 None
 1.07A 4o1zA-1ci9A:
0.0		 4o1zA-1ci9A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA602_1
(SERUM ALBUMIN)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 8 ALA A  82
GLY A 274
LEU A 185
LEU A 125
 None
 0.85A 4po0A-1ci9A:
undetectable		 4po0A-1ci9A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QCK_A_ASDA404_1
(3-KETOSTEROID-9-ALPH
A-MONOOXYGENASE
OXYGENASE SUBUNIT)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 ASN A 162
LEU A 124
ALA A 167
LEU A 104
GLY A 189
 None
 1.30A 4qckA-1ci9A:
undetectable		 4qckA-1ci9A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_B_QI9B602_0
(CYTOCHROME P450 2D6)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 9 PHE A 219
LEU A 185
SER A 272
VAL A 192
VAL A 204
 None
 1.33A 4wnvB-1ci9A:
0.0		 4wnvB-1ci9A:
25.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		3 / 3 LEU A  22
ASP A  27
ILE A  41
 None
 0.58A 4xi3D-1ci9A:
0.0		 4xi3D-1ci9A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z90_F_4LEF402_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 7 LEU A 369
ALA A 281
LEU A 367
ALA A 287
LEU A  73
 None
 1.01A 4z90F-1ci9A:
0.0
4z90G-1ci9A:
0.0
4z90H-1ci9A:
0.0
4z90J-1ci9A:
0.0		 4z90F-1ci9A:
21.38
4z90G-1ci9A:
21.38
4z90H-1ci9A:
21.38
4z90J-1ci9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_J_4LEJ401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		6 / 9 LEU A  73
LEU A 369
ALA A 281
LEU A 367
LEU A 288
ALA A 287
 None
 1.21A 4z91F-1ci9A:
0.0
4z91G-1ci9A:
0.0
4z91H-1ci9A:
0.0
4z91I-1ci9A:
0.0
4z91J-1ci9A:
0.0		 4z91F-1ci9A:
21.38
4z91G-1ci9A:
21.38
4z91H-1ci9A:
21.38
4z91I-1ci9A:
21.38
4z91J-1ci9A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B2Q_A_ACTA1728_0
(CRISPR-ASSOCIATED
ENDONUCLEASE CAS9)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		3 / 3 ASN A 162
SER A 149
ARG A 263
 None
 0.94A 5b2qA-1ci9A:
undetectable		 5b2qA-1ci9A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AYC_A_1YNA502_1
(PROTEIN CYP51)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 12 ALA A 329
MET A 277
PHE A 219
ALA A 201
ALA A 203
 None
 1.37A 6aycA-1ci9A:
undetectable		 6aycA-1ci9A:
11.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EU9_D_READ601_1
(RETINOIC ACID
RECEPTOR)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 7 VAL A 204
GLY A 273
LEU A  73
GLY A 279
 None
 0.68A 6eu9D-1ci9A:
0.0		 6eu9D-1ci9A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBV_D_FI8D1904_1
(DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA')		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 8 ASP A 283
ARG A 215
ARG A 226
VAL A 264
 None
 1.18A 6fbvD-1ci9A:
0.0		 6fbvD-1ci9A:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_I_PCFI101_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 1,
MITOCHONDRIAL
CYTOCHROME B-C1
COMPLEX SUBUNIT 9
CYTOCHROME B-C1
COMPLEX SUBUNIT
RIESKE,
MITOCHONDRIAL)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		5 / 11 ASP A 186
SER A 272
VAL A 351
GLY A 353
ALA A  38
 None
None
DFP  A 401 (-3.2A)
None
None
 1.29A 6hu9A-1ci9A:
0.0
6hu9E-1ci9A:
undetectable
6hu9I-1ci9A:
0.0		 6hu9A-1ci9A:
22.00
6hu9E-1ci9A:
18.11
6hu9I-1ci9A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_S_PCFS603_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1ci9 PROTEIN
(CARBOXYLESTERASE)
(Burkholderia
gladioli) 		4 / 7 GLY A 151
VAL A 264
SER A  75
LYS A  78
 None
None
DFP  A 401 (-1.6A)
DFP  A 401 ( 4.2A)
 1.00A 6hu9S-1ci9A:
0.0
6hu9q-1ci9A:
undetectable		 6hu9S-1ci9A:
10.67
6hu9q-1ci9A:
17.80