SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cia'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		9 / 10 THR A  94
PHE A 103
ALA A 105
PHE A 135
ASN A 146
LEU A 160
VAL A 162
TYR A 168
ILE A 172
 None
None
BME  A 536 ( 4.3A)
None
None
None
None
None
None
 0.26A 1claA-1ciaA:
37.2		 1claA-1ciaA:
99.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.57A 1q23A-1ciaA:
32.4
1q23B-1ciaA:
32.2		 1q23A-1ciaA:
44.95
1q23B-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_B_FUAB703_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 12 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
THR A 174
 None
 0.58A 1q23B-1ciaA:
32.2		 1q23B-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 12 THR A  94
PHE A 103
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.61A 1q23C-1ciaA:
32.6		 1q23C-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_D_FUAD705_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.54A 1q23D-1ciaA:
32.3
1q23E-1ciaA:
32.3		 1q23D-1ciaA:
44.95
1q23E-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_F_FUAF704_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 11 THR A  94
PHE A 135
LEU A 160
VAL A 162
THR A 174
 None
 0.65A 1q23F-1ciaA:
32.6		 1q23F-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_G_FUAG708_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 11 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.58A 1q23G-1ciaA:
32.6		 1q23G-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_I_FUAI707_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 11 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.68A 1q23I-1ciaA:
32.2		 1q23I-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_J_FUAJ711_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 11 THR A  94
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.62A 1q23J-1ciaA:
32.3		 1q23J-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1Q23_L_FUAL710_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		6 / 11 THR A  94
PHE A 103
PHE A 135
PHE A 158
LEU A 160
VAL A 162
 None
 0.56A 1q23L-1ciaA:
32.1		 1q23L-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QCA_A_FUAA221_1
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 7 THR A  94
PHE A 103
SER A 107
PHE A 135
LEU A 160
 None
 0.26A 1qcaA-1ciaA:
36.5		 1qcaA-1ciaA:
97.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CC8_A_RBFA1067_1
(VNG1446H)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 PHE A  22
VAL A  13
TRP A  16
 None
 0.54A 2cc8A-1ciaA:
0.9		 2cc8A-1ciaA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CCB_A_RBFA1067_1
(VNG1446H)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 PHE A  22
VAL A  13
TRP A  16
 None
 0.54A 2ccbA-1ciaA:
1.0		 2ccbA-1ciaA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VX9_A_RBFA1064_1
(DODECIN)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 PHE A  22
VAL A  13
TRP A  16
 None
 0.53A 2vx9A-1ciaA:
0.9		 2vx9A-1ciaA:
18.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		8 / 9 GLN A  92
ALA A 105
PHE A 135
ASN A 146
LEU A 160
VAL A 162
TYR A 168
ILE A 172
 None
BME  A 536 ( 4.3A)
None
None
None
None
None
None
 0.28A 3claA-1ciaA:
37.4		 3claA-1ciaA:
99.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM0_B_CHDB151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A  39
ILE A 207
VAL A 203
PRO A 171
LEU A 213
 None
 1.10A 3em0B-1ciaA:
0.0		 3em0B-1ciaA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OZU_A_X89A411_1
(FLAVOHEMOPROTEIN)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 ILE A  60
TYR A 121
ALA A 149
HIS A  97
LEU A 134
 None
 0.66A 3ozuA-1ciaA:
undetectable		 3ozuA-1ciaA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 7 VAL A 191
LEU A 210
MET A  59
ILE A  63
 None
 0.92A 3rfmA-1ciaA:
undetectable		 3rfmA-1ciaA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 4 PHE A 169
TYR A  25
ILE A 173
LEU A 145
 None
 1.48A 3sudA-1ciaA:
0.0		 3sudA-1ciaA:
21.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9F_E_CLME221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 10 THR A  94
PHE A 103
PHE A 135
LEU A 160
VAL A 162
 None
 0.51A 3u9fE-1ciaA:
31.7		 3u9fE-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9F_K_CLMK221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 10 THR A  94
PHE A 103
PHE A 135
LEU A 160
VAL A 162
 None
 0.45A 3u9fK-1ciaA:
32.2		 3u9fK-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 THR A  94
PHE A 103
PHE A 135
LEU A 160
VAL A 162
 None
 0.45A 3u9fJ-1ciaA:
32.2
3u9fL-1ciaA:
32.1		 3u9fJ-1ciaA:
44.95
3u9fL-1ciaA:
44.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		9 / 11 GLN A  92
THR A  94
ALA A 105
LEU A 134
PHE A 135
ASN A 146
VAL A 162
TYR A 168
ILE A 172
 None
None
BME  A 536 ( 4.3A)
None
None
None
None
None
None
 0.22A 4claA-1ciaA:
37.3		 4claA-1ciaA:
99.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_2
(GLUCOCORTICOID
RECEPTOR)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 MET A 118
GLN A 137
TYR A 128
 None
 0.90A 4udcA-1ciaA:
0.0		 4udcA-1ciaA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YO9_B_ACTB401_0
(3C-LIKE PROTEINASE)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		3 / 3 ARG A  18
ASP A 199
TYR A  25
 None
 0.81A 4yo9B-1ciaA:
0.0		 4yo9B-1ciaA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		4 / 5 CYH A 108
GLN A  92
PRO A  91
ILE A  60
 None
 1.13A 5ki6A-1ciaA:
0.0		 5ki6A-1ciaA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA502_1
(CYTOCHROME P450 2C9)		 1cia CHLORAMPHENICOL
ACETYLTRANSFERASE
(Escherichia
coli) 		5 / 12 PHE A  55
MET A 125
ALA A 149
LEU A 189
LEU A 187
 None
 1.21A 5x23A-1ciaA:
0.0		 5x23A-1ciaA:
19.86