SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cii'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_1
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN))		 1cii COLICIN IA
(Escherichia
coli) 		4 / 6 LEU A 567
TRP A 551
PHE A 555
VAL A 559
 None
 1.33A 1ibgH-1ciiA:
0.0		 1ibgH-1ciiA:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7F_A_BCZA801_0
(NEURAMINIDASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 GLU A  97
ARG A 101
ILE A 150
ARG A  95
GLU A  92
 None
 1.35A 1l7fA-1ciiA:
undetectable		 1l7fA-1ciiA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L7H_A_BCZA801_0
(NEURAMINIDASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 GLU A  97
ARG A 101
ILE A 150
ARG A  95
GLU A  92
 None
 1.36A 1l7hA-1ciiA:
undetectable		 1l7hA-1ciiA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 LEU A 596
SER A 594
VAL A 523
ALA A 517
ALA A 518
 None
 1.23A 1n5xA-1ciiA:
undetectable		 1n5xA-1ciiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_A_TEIA3006_1
(XANTHINE
DEHYDROGENASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 LEU A 604
LEU A 596
SER A 594
VAL A 523
ALA A 518
 None
 1.09A 1n5xA-1ciiA:
undetectable		 1n5xA-1ciiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 LEU A 596
SER A 594
VAL A 523
ALA A 517
ALA A 518
 None
 1.22A 1n5xB-1ciiA:
undetectable		 1n5xB-1ciiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N5X_B_TEIB4006_1
(XANTHINE
DEHYDROGENASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 LEU A 604
LEU A 596
SER A 594
VAL A 523
ALA A 518
 None
 1.09A 1n5xB-1ciiA:
undetectable		 1n5xB-1ciiA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_C_H4BC1002_1
(HYPOTHETICAL PROTEIN
PH0634)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 6 TYR A  30
ASP A  28
THR A 449
GLU A  23
 None
 1.17A 2dttB-1ciiA:
0.6
2dttC-1ciiA:
0.5		 2dttB-1ciiA:
11.33
2dttC-1ciiA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HTU_A_BCZA801_0
(NEURAMINIDASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 GLU A  97
ARG A 101
ILE A 150
ARG A  95
GLU A  92
 None
 1.47A 2htuA-1ciiA:
undetectable		 2htuA-1ciiA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AX9_A_SALA1341_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 8 LEU A 596
SER A 594
VAL A 523
ALA A 518
 None
 1.00A 3ax9A-1ciiA:
3.7		 3ax9A-1ciiA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PGY_B_GLYB511_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 5 GLU A 477
LEU A 474
GLN A 473
LYS A 470
 None
 0.86A 3pgyB-1ciiA:
0.0		 3pgyB-1ciiA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH503_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 7 ARG A 513
ALA A 514
ILE A 516
GLY A 556
 None
 0.89A 3v4tH-1ciiA:
undetectable		 3v4tH-1ciiA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW7_A_VPXA2001_1
(PROTEINASE-ACTIVATED
RECEPTOR 1, LYSOZYME)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 LEU A 583
LEU A 567
LEU A 596
ALA A 517
ALA A 519
 None
 1.10A 3vw7A-1ciiA:
0.0		 3vw7A-1ciiA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGJ_A_1PQA303_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 1cii COLICIN IA
(Escherichia
coli) 		5 / 9 TRP A 564
GLY A 602
GLY A 600
PHE A 555
ILE A 590
 None
 1.16A 4fgjA-1ciiA:
undetectable
4fgjB-1ciiA:
undetectable		 4fgjA-1ciiA:
15.80
4fgjB-1ciiA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_E_ACTE503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 4 LYS A 117
LEU A 116
GLU A 113
LEU A 136
 None
 1.41A 4k4yE-1ciiA:
0.0		 4k4yE-1ciiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K4Y_I_ACTI503_0
(RNA-DEPENDENT RNA
POLYMERASE)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 5 LYS A 117
LEU A 116
GLU A 113
LEU A 136
 None
 1.37A 4k4yI-1ciiA:
0.0		 4k4yI-1ciiA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MWV_A_BCZA513_0
(NEURAMINIDASE)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 GLU A  97
ARG A 101
ILE A 150
ARG A  95
GLU A  92
 None
 1.36A 4mwvA-1ciiA:
undetectable		 4mwvA-1ciiA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_B_RBFB201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 8 THR A 608
ILE A 575
LEU A 591
LEU A 539
 None
 0.84A 4r38B-1ciiA:
0.0		 4r38B-1ciiA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R38_D_RBFD201_2
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 8 THR A 608
ILE A 575
LEU A 591
LEU A 539
 None
 0.82A 4r38D-1ciiA:
0.0		 4r38D-1ciiA:
12.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 6 ASP A 304
ALA A 371
LYS A 375
THR A 322
 None
 1.35A 4z4iA-1ciiA:
undetectable		 4z4iA-1ciiA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 8 LEU A 596
GLY A 597
ALA A 519
LEU A 520
GLY A 593
 None
 1.28A 4zauA-1ciiA:
undetectable		 4zauA-1ciiA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESE_A_TPFA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 1cii COLICIN IA
(Escherichia
coli) 		4 / 8 LEU A 604
PHE A 555
THR A 571
LEU A 583
 None
 0.84A 5eseA-1ciiA:
0.0		 5eseA-1ciiA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JW1_A_CELA602_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 12 VAL A 587
LEU A 591
ALA A 558
VAL A 607
GLY A 609
 None
 1.03A 5jw1A-1ciiA:
0.0		 5jw1A-1ciiA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_F_SAMF501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 1cii COLICIN IA
(Escherichia
coli) 		5 / 10 GLN A  88
GLU A 161
LEU A 156
ARG A 157
ALA A 155
 None
 1.18A 5o96E-1ciiA:
undetectable
5o96F-1ciiA:
undetectable		 5o96E-1ciiA:
19.02
5o96F-1ciiA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VCG_A_08YA602_2
(CYTOCHROME P450 3A4)		 1cii COLICIN IA
(Escherichia
coli) 		3 / 3 ARG A 109
ARG A 142
ARG A 135
 None
 0.92A 5vcgA-1ciiA:
0.0		 5vcgA-1ciiA:
23.16