SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cit'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3004_0
(BETA-CARBONIC
ANHYDRASE)		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 6 CYH A 232
ASP A 237
VAL A 234
GLY A 251
 ZN  A 398 ( 2.7A)
None
ZN  A 398 ( 4.7A)
None
 1.01A 1ekjC-1citA:
undetectable
1ekjD-1citA:
undetectable		 1ekjC-1citA:
14.61
1ekjD-1citA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_C_ACTC3007_0
(BETA-CARBONIC
ANHYDRASE)		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 6 CYH A 232
ASP A 237
VAL A 234
GLY A 251
 ZN  A 398 ( 2.7A)
None
ZN  A 398 ( 4.7A)
None
 0.98A 1ekjC-1citA:
undetectable
1ekjD-1citA:
undetectable		 1ekjC-1citA:
14.61
1ekjD-1citA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PWY_E_AC2E290_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		5 / 10 GLY A 296
PHE A 256
VAL A 246
GLY A 245
VAL A 295
 None
 1.28A 1pwyE-1citA:
undetectable		 1pwyE-1citA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLD_A_ASCA130_0
(CYTOCHROME C')		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 5 ALA A 233
GLY A 251
CYH A 252
LYS A 253
 None
None
ZN  A 398 ( 2.5A)
None
 1.24A 2yldA-1citA:
undetectable		 2yldA-1citA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YLG_A_ASCA130_0
(CYTOCHROME C')		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 5 ALA A 233
GLY A 251
CYH A 252
LYS A 253
 None
None
ZN  A 398 ( 2.5A)
None
 1.16A 2ylgA-1citA:
undetectable		 2ylgA-1citA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZWI_A_ASCA156_0
(CYTOCHROME C')		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 5 ALA A 233
GLY A 251
CYH A 252
LYS A 253
 None
None
ZN  A 398 ( 2.5A)
None
 1.27A 3zwiA-1citA:
undetectable		 3zwiA-1citA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_A_ACTA505_0
(RNA POLYMERASE
3D-POL)		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		3 / 3 CYH A 232
ASN A 238
LYS A 278
 ZN  A 398 ( 2.7A)
None
None
 1.41A 4k50A-1citA:
undetectable		 4k50A-1citA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_I_ACTI504_0
(RNA POLYMERASE
3D-POL)		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		3 / 3 VAL A 234
GLY A 236
LYS A 278
 ZN  A 398 ( 4.7A)
None
None
 0.78A 4k50I-1citA:
undetectable		 4k50I-1citA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DBY_A_ACTA610_0
(SERUM ALBUMIN)		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		3 / 3 TYR A 244
LYS A 257
LYS A 253
 None
 0.84A 5dbyA-1citA:
undetectable		 5dbyA-1citA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JLI_A_ASCA202_0
(CYTOCHROME C')		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 5 ALA A 233
GLY A 251
CYH A 252
LYS A 253
 None
None
ZN  A 398 ( 2.5A)
None
 1.12A 5jliA-1citA:
undetectable		 5jliA-1citA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JT4_A_ASCA202_0
(CYTOCHROME C')		 1cit PROTEIN (ORPHAN
NUCLEAR RECEPTOR
NGFI-B)
(Rattus
norvegicus) 		4 / 5 ALA A 233
GLY A 251
CYH A 252
LYS A 253
 None
None
ZN  A 398 ( 2.5A)
None
 1.16A 5jt4A-1citA:
undetectable		 5jt4A-1citA:
22.50