SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1civ'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_2
(PROTEIN (HIV-1
PROTEASE))		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 8 ARG A 250
LEU A 253
ALA A 209
ILE A 241
PHE A 233
 None
 1.13A 1d4sB-1civA:
0.0		 1d4sB-1civA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK1_A_T44A3003_1
(SERUM ALBUMIN)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		4 / 6 HIS A  57
ILE A  54
ALA A 287
VAL A 167
 None
NAP  A 386 (-3.6A)
None
NAP  A 386 (-4.7A)
 1.04A 1hk1A-1civA:
undetectable		 1hk1A-1civA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 GLY A  49
GLY A  52
ALA A  87
LEU A  88
LEU A 124
 NAP  A 386 (-3.2A)
NAP  A 386 (-3.2A)
None
None
None
 1.25A 1i9gA-1civA:
7.1		 1i9gA-1civA:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ICT_C_T44C128_1
(TRANSTHYRETIN)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 11 LEU A 154
ALA A  46
LEU A  79
SER A  48
VAL A 162
 None
None
NAP  A 386 ( 4.8A)
NAP  A 386 ( 4.7A)
None
 1.22A 1ictA-1civA:
0.0
1ictC-1civA:
undetectable		 1ictA-1civA:
15.80
1ictC-1civA:
15.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IGX_A_EPAA700_2
(PROSTAGLANDIN
ENDOPEROXIDE H
SYNTHASE-1)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		4 / 8 VAL A  91
VAL A  45
VAL A  47
LEU A  59
 None
 0.91A 1igxA-1civA:
0.0		 1igxA-1civA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F80_B_017B301_1
(POL POLYPROTEIN)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 LEU A  62
GLY A  69
ASP A  71
VAL A  45
ILE A  74
 None
 0.99A 2f80A-1civA:
undetectable		 2f80A-1civA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8G_B_017B401_1
(POL POLYPROTEIN)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 LEU A  62
GLY A  69
ASP A  71
VAL A  45
ILE A  74
 None
 0.99A 2f8gA-1civA:
undetectable		 2f8gA-1civA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS2_A_017A201_1
(PROTEASE)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 LEU A  62
GLY A  69
ASP A  71
VAL A  45
ILE A  74
 None
 0.96A 2hs2A-1civA:
undetectable		 2hs2A-1civA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_A_CELA682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 HIS A  57
VAL A  91
LEU A  95
GLY A  49
LEU A  78
 None
None
None
NAP  A 386 (-3.2A)
None
 1.07A 3ln1A-1civA:
0.0		 3ln1A-1civA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_B_CELB682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 HIS A  57
VAL A  91
LEU A  95
GLY A  49
LEU A  78
 None
None
None
NAP  A 386 (-3.2A)
None
 1.06A 3ln1B-1civA:
0.0		 3ln1B-1civA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_C_CELC682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 HIS A  57
VAL A  91
LEU A  95
GLY A  49
LEU A  78
 None
None
None
NAP  A 386 (-3.2A)
None
 1.07A 3ln1C-1civA:
0.0		 3ln1C-1civA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LN1_D_CELD682_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 HIS A  57
VAL A  91
LEU A  95
GLY A  49
LEU A  78
 None
None
None
NAP  A 386 (-3.2A)
None
 1.06A 3ln1D-1civA:
0.0		 3ln1D-1civA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Z_A_FLPA701_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 VAL A  91
LEU A  95
GLY A  49
ALA A  50
LEU A  78
 None
None
NAP  A 386 (-3.2A)
NAP  A 386 (-4.9A)
None
 1.07A 3n8zA-1civA:
0.0		 3n8zA-1civA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RAE_F_LFXF101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		3 / 4 SER A  48
GLY A 144
GLU A 358
 NAP  A 386 ( 4.7A)
None
None
 0.65A 3raeA-1civA:
0.0
3raeC-1civA:
1.7		 3raeA-1civA:
20.00
3raeC-1civA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AMJ_A_CVDA1359_1
(BETA-1 ADRENERGIC
RECEPTOR)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 VAL A 167
VAL A 166
SER A  48
PHE A 147
ASN A 143
 NAP  A 386 (-4.7A)
None
NAP  A 386 ( 4.7A)
None
None
 1.41A 4amjA-1civA:
undetectable		 4amjA-1civA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_1
(PROTEASE)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 LEU A  62
GLY A  69
ASP A  71
VAL A  45
ILE A  74
 None
 0.98A 4hlaA-1civA:
undetectable		 4hlaA-1civA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HLA_A_017A200_2
(PROTEASE)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 11 LEU A  62
GLY A  69
ASP A  71
VAL A  45
ILE A  74
 None
 0.97A 4hlaB-1civA:
undetectable		 4hlaB-1civA:
15.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1Z_A_MXMA807_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		4 / 6 VAL A  45
LEU A  76
LEU A  58
PHE A 147
 None
 1.10A 4o1zA-1civA:
0.0		 4o1zA-1civA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZN7_A_DESA601_1
(ESTROGEN RECEPTOR)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 ALA A  50
LEU A  95
LEU A  59
LEU A  62
LEU A  88
 NAP  A 386 (-4.9A)
None
None
None
None
 1.21A 4zn7A-1civA:
0.0		 4zn7A-1civA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_1
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		3 / 3 ARG A 136
ASN A 224
ASP A 197
 None
None
NAP  A 386 ( 4.8A)
 0.60A 5gwxA-1civA:
6.2		 5gwxA-1civA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGT_A_ERYA402_0
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 HIS A  57
ALA A  51
VAL A  47
LEU A  88
GLY A  90
 None
NAP  A 386 (-3.4A)
None
None
None
 1.05A 5igtA-1civA:
0.0		 5igtA-1civA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BQG_A_ERMA1201_1
(5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		5 / 12 SER A  81
VAL A 167
ALA A  87
SER A 275
GLU A 384
 NAP  A 386 (-3.0A)
NAP  A 386 (-4.7A)
None
NAP  A 386 ( 4.6A)
NAP  A 386 (-3.9A)
 1.14A 6bqgA-1civA:
undetectable		 6bqgA-1civA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EMU_A_SAMA501_0
(TRNA
(GUANINE(9)-/ADENINE
(9)-N1)-METHYLTRANSF
ERASE)		 1civ NADP-MALATE
DEHYDROGENASE
(Flaveria
bidentis) 		6 / 12 PRO A 323
GLY A 223
ILE A 348
VAL A 219
ASP A 232
ILE A 221
 None
 1.48A 6emuA-1civA:
2.0		 6emuA-1civA:
21.70