SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cj0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_A_BEZA295_0
(CHLOROPEROXIDASE T)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 10 GLY A 389
LEU A 362
PHE A3993
THR A 328
LEU A 323
None
1.35A 1a8uA-1cj0A:
2.0
1a8uA-1cj0A:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1A8U_B_BEZB294_0
(CHLOROPEROXIDASE T)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 10 GLY A 389
LEU A 362
PHE A3993
THR A 328
LEU A 323
None
1.39A 1a8uB-1cj0A:
undetectable
1a8uB-1cj0A:
21.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.83A 1dfoA-1cj0A:
51.0
1dfoA-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_A_FFOA1002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.74A 1dfoB-1cj0A:
51.5
1dfoB-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.75A 1dfoA-1cj0A:
51.0
1dfoA-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_B_FFOB2002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.84A 1dfoB-1cj0A:
51.5
1dfoB-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.83A 1dfoC-1cj0A:
51.4
1dfoC-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_C_FFOC3002_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.75A 1dfoD-1cj0A:
51.1
1dfoD-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 5 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.75A 1dfoC-1cj0A:
51.4
1dfoC-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DFO_D_FFOD4002_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.83A 1dfoD-1cj0A:
51.1
1dfoD-1cj0A:
45.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.84A 1eqbA-1cj0A:
50.9
1eqbA-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_FFOA1293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 GLU A  57
TYR A  64
PHE A 257
None
0.67A 1eqbB-1cj0A:
51.4
1eqbB-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_A_GLYA1292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
6 / 8 SER A  35
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
0.74A 1eqbA-1cj0A:
50.9
1eqbB-1cj0A:
51.4
1eqbA-1cj0A:
45.22
1eqbB-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 GLU A  57
TYR A  64
PHE A 257
None
0.66A 1eqbA-1cj0A:
50.9
1eqbA-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_FFOB2293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.84A 1eqbB-1cj0A:
51.4
1eqbB-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_B_GLYB2292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
6 / 8 SER A  35
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
0.73A 1eqbA-1cj0A:
50.9
1eqbB-1cj0A:
51.4
1eqbA-1cj0A:
45.22
1eqbB-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.84A 1eqbC-1cj0A:
51.3
1eqbC-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_FFOC3293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 GLU A  57
TYR A  64
PHE A 257
None
0.66A 1eqbD-1cj0A:
50.9
1eqbD-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_C_GLYC3292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
6 / 8 SER A  35
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
0.73A 1eqbC-1cj0A:
51.3
1eqbD-1cj0A:
50.9
1eqbC-1cj0A:
45.22
1eqbD-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 GLU A  57
TYR A  64
PHE A 257
None
0.67A 1eqbC-1cj0A:
51.3
1eqbC-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_FFOD4293_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 347
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.84A 1eqbD-1cj0A:
50.9
1eqbD-1cj0A:
45.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1EQB_D_GLYD4292_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
6 / 8 SER A  35
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
0.73A 1eqbC-1cj0A:
51.3
1eqbD-1cj0A:
50.9
1eqbC-1cj0A:
45.22
1eqbD-1cj0A:
45.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_A_THAA1_1
(LIVER
CARBOXYLESTERASE I)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 11 LEU A 362
GLY A 330
GLY A 331
LEU A 399
LEU A 337
None
1.13A 1mx1A-1cj0A:
undetectable
1mx1A-1cj0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 LEU A 399
GLY A 331
GLY A 330
LEU A 362
LEU A 323
None
0.80A 1mx1D-1cj0A:
undetectable
1mx1D-1cj0A:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JJP_A_KLNA413_1
(CYTOCHROME P450
113A1)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 ALA A 101
ALA A 104
THR A 107
PHE A1401
ILE A 116
None
1.26A 2jjpA-1cj0A:
0.0
2jjpA-1cj0A:
22.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 6 GLU A  57
TYR A  64
TYR A  65
PHE A 257
PRO A 258
None
0.72A 2vmyA-1cj0A:
51.2
2vmyA-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
0.47A 2vmyB-1cj0A:
51.2
2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_FFOA505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 LEU A 121
GLY A 124
HIS A 126
SER A 175
ARG A 363
None
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
None
0.52A 2vmyB-1cj0A:
51.2
2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 7 SER A  35
HIS A 126
HIS A 203
LYS A 229
ARG A 363
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
0.72A 2vmyA-1cj0A:
51.2
2vmyB-1cj0A:
51.2
2vmyA-1cj0A:
45.06
2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
7 / 12 LEU A 121
GLY A 124
HIS A 126
LEU A 127
SER A 175
ASN A 345
ARG A 363
None
None
PLP  A2291 ( 3.8A)
None
PLP  A2291 (-2.9A)
None
None
0.68A 2vmyA-1cj0A:
51.2
2vmyA-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_FFOB505_1
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 4 GLU A  57
TYR A  64
TYR A  65
PHE A 257
None
0.84A 2vmyB-1cj0A:
51.2
2vmyB-1cj0A:
45.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2VMY_B_GLYB502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
6 / 8 SER A  35
HIS A 126
SER A 175
HIS A 203
LYS A 229
ARG A 363
None
PLP  A2291 ( 3.8A)
PLP  A2291 (-2.9A)
PLP  A2291 (-4.0A)
PLP  A2291 (-1.4A)
None
0.69A 2vmyA-1cj0A:
51.2
2vmyB-1cj0A:
51.2
2vmyA-1cj0A:
45.06
2vmyB-1cj0A:
45.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B0W_B_DGXB1_1
(NUCLEAR RECEPTOR
ROR-GAMMA)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 CYH A 344
ALA A 368
ALA A 417
LEU A 362
LEU A 302
None
1.36A 3b0wB-1cj0A:
0.6
3b0wB-1cj0A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3002_1
(TRANSCRIPTIONAL
REGULATOR TCAR)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 8 VAL A 105
LEU A 109
ILE A 239
VAL A 222
LEU A2501
None
1.19A 3kp6A-1cj0A:
undetectable
3kp6B-1cj0A:
0.0
3kp6A-1cj0A:
14.98
3kp6B-1cj0A:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXC_A_ROCA401_2
(PROTEASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 ARG A 363
LEU A 318
THR A 230
None
0.79A 3oxcA-1cj0A:
undetectable
3oxcA-1cj0A:
12.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3PGY_A_GLYA510_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 6 GLU A  31
ILE A  33
PHE A  38
ALA A 368
None
0.93A 3pgyA-1cj0A:
48.5
3pgyB-1cj0A:
49.2
3pgyA-1cj0A:
44.23
3pgyB-1cj0A:
44.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 9 ARG A 363
LEU A 318
ASN A 316
VAL A 291
GLY A 206
None
1.16A 3spkA-1cj0A:
undetectable
3spkA-1cj0A:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_A_9PLA501_1
(CYTOCHROME P450 2E1)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 6 LEU A2501
ALA A 199
THR A 224
LEU A 169
None
1.00A 3t3zA-1cj0A:
undetectable
3t3zA-1cj0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_B_9PLB501_1
(CYTOCHROME P450 2E1)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 6 LEU A2501
ALA A 199
THR A 224
LEU A 169
None
1.00A 3t3zB-1cj0A:
undetectable
3t3zB-1cj0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3Z_D_9PLD501_1
(CYTOCHROME P450 2E1)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 6 LEU A2501
ALA A 199
THR A 224
LEU A 169
None
1.00A 3t3zD-1cj0A:
undetectable
3t3zD-1cj0A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_D_NCTD501_1
(CYTOCHROME P450 2A13)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 6 PHE A 240
PHE A 217
ALA A  85
LEU A 231
None
0.96A 4ejgD-1cj0A:
undetectable
4ejgD-1cj0A:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2V_A_BZ1A302_2
(CARBONIC ANHYDRASE 2)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 HIS A 265
VAL A  43
LEU A  47
None
0.74A 4m2vA-1cj0A:
0.0
4m2vA-1cj0A:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OAE_A_CLMA207_0
(GNAT SUPERFAMILY
ACETYLTRANSFERASE
PA4794)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 ALA A  42
ARG A  81
ALA A 279
GLY A 233
LEU A 231
None
1.05A 4oaeA-1cj0A:
undetectable
4oaeA-1cj0A:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP8_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 11 THR A 138
HIS A 129
ILE A 171
ASP A 200
ALA A 202
None
None
None
PLP  A2291 (-3.0A)
PLP  A2291 (-3.4A)
1.40A 4rp8A-1cj0A:
0.0
4rp8A-1cj0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RP9_A_ASCA501_0
(ASCORBATE-SPECIFIC
PERMEASE IIC
COMPONENT ULAA)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 THR A 138
HIS A 129
ILE A 171
ASP A 200
ALA A 202
None
None
None
PLP  A2291 (-3.0A)
PLP  A2291 (-3.4A)
1.45A 4rp9A-1cj0A:
0.0
4rp9A-1cj0A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UBE_A_2FAA401_2
(ADENOSINE KINASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 4 ALA A 273
VAL A  93
GLY A 237
THR A 227
None
1.15A 4ubeA-1cj0A:
3.0
4ubeA-1cj0A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_2
(CYTOCHROME P450
21-HYDROXYLASE)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
3 / 3 LEU A 364
VAL A 310
ASP A 322
None
0.70A 4y8wC-1cj0A:
0.0
4y8wC-1cj0A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IEP_A_VDYA201_2
(CDL2.3B)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 9 ILE A 319
VAL A 213
LEU A 207
ILE A 204
LEU A 298
None
1.15A 5iepA-1cj0A:
0.5
5iepA-1cj0A:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L0Z_B_SAMB304_0
(PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 10 LEU A 402
GLY A 389
GLN A4061
LEU A4111
ALA A 408
None
1.03A 5l0zB-1cj0A:
undetectable
5l0zB-1cj0A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA501_1
(CYTOCHROME P450 2C9)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
5 / 12 ALA A 356
ASP A 123
GLY A 125
LEU A 318
LEU A 320
None
1.02A 5xxiA-1cj0A:
0.0
5xxiA-1cj0A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_A_GLYA715_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)
1cj0 PROTEIN (SERINE
HYDROXYMETHYLTRANSFE
RASE)

(Oryctolagus
cuniculus)
4 / 6 ASP A 352
SER A 360
ARG A 358
ARG A 324
None
0.90A 6dwdA-1cj0A:
0.0
6dwdC-1cj0A:
0.1
6dwdA-1cj0A:
22.01
6dwdC-1cj0A:
22.01