SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cja'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MOG_A_RBFA200_1
(DODECIN)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 PHE A  95
TRP A  66
GLU A 132
 None
 1.18A 1mogA-1cjaA:
undetectable		 1mogA-1cjaA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_2
(LIVER
CARBOXYLESTERASE I)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 PHE A 303
LEU A 116
LEU A 112
 None
 0.66A 1mx1E-1cjaA:
undetectable		 1mx1E-1cjaA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_A_TEPA1434_1
(CHITINASE)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 TRP A  66
THR A  90
TYR A  58
 None
 1.04A 2a3aA-1cjaA:
undetectable		 2a3aA-1cjaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3A_B_TEPB2434_1
(CHITINASE)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 TRP A  66
THR A  90
TYR A  58
 None
 1.09A 2a3aB-1cjaA:
undetectable		 2a3aB-1cjaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A3B_A_CFFA1434_1
(CHITINASE)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 TRP A  66
THR A  90
TYR A  58
 None
 1.06A 2a3bA-1cjaA:
undetectable		 2a3bA-1cjaA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FUM_C_MIXC2539_1
(PROBABLE
SERINE/THREONINE-PRO
TEIN KINASE PKNB)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		6 / 12 MET A 162
VAL A 165
THR A 169
ASN A 218
MET A 220
ASP A 232
 AMP  A 425 (-4.4A)
AMP  A 425 (-4.0A)
AMP  A 425 ( 4.3A)
None
AMP  A 425 ( 4.0A)
AMP  A 425 (-2.7A)
 0.73A 2fumC-1cjaA:
5.7		 2fumC-1cjaA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA502_1
(CYTOCHROME P450 2C8)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		5 / 12 SER A 268
ILE A 269
ILE A 208
ASN A 215
VAL A 198
 None
 1.05A 2nnhA-1cjaA:
0.0		 2nnhA-1cjaA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_A_RIMA199_1
(MATRIX PROTEIN 2)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 6 LEU A 193
LEU A 196
ASP A 197
ILE A 219
 None
 0.94A 2rlfA-1cjaA:
0.0
2rlfB-1cjaA:
0.0		 2rlfA-1cjaA:
9.69
2rlfB-1cjaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 6 LEU A 193
LEU A 196
ASP A 197
ILE A 219
 None
 1.04A 2rlfB-1cjaA:
0.0
2rlfC-1cjaA:
0.0		 2rlfB-1cjaA:
9.69
2rlfC-1cjaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_C_RIMC399_1
(MATRIX PROTEIN 2)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 6 LEU A 193
LEU A 196
ASP A 197
ILE A 219
 None
 0.95A 2rlfC-1cjaA:
0.0
2rlfD-1cjaA:
0.0		 2rlfC-1cjaA:
9.69
2rlfD-1cjaA:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUL_A_SAMA376_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 SER A 233
GLU A 163
ASP A  60
 None
 0.70A 2zulA-1cjaA:
undetectable		 2zulA-1cjaA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMH_A_SAMA384_1
(PROBABLE RIBOSOMAL
RNA SMALL SUBUNIT
METHYLTRANSFERASE)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 SER A 233
GLU A 163
ASP A  60
 None
 0.69A 3dmhA-1cjaA:
undetectable		 3dmhA-1cjaA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_A_ERYA195_1
(REPRESSOR PROTEIN
MPHR(A))		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 5 ASN A 212
ASN A 201
HIS A 244
ALA A 209
 None
 1.26A 3frqA-1cjaA:
0.1		 3frqA-1cjaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 7 ASN A 212
ASN A 201
HIS A 244
ALA A 209
 None
 1.28A 3frqB-1cjaA:
0.1		 3frqB-1cjaA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 LYS A   2
ILE A  96
PHE A  86
 None
 1.01A 3j7zS-1cjaA:
0.0
3j7za-1cjaA:
undetectable		 3j7zS-1cjaA:
17.42
3j7za-1cjaA:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 GLU A 106
LEU A 160
LEU A 164
 None
None
AMP  A 425 ( 4.8A)
 0.64A 3ohtA-1cjaA:
2.6		 3ohtA-1cjaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 GLU A 106
LEU A 160
LEU A 164
 None
None
AMP  A 425 ( 4.8A)
 0.62A 3ohtB-1cjaA:
4.0		 3ohtB-1cjaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ1_X_DXCX75_0
(CYTOCHROME C7)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 6 LEU A 255
PHE A 266
MET A 289
GLY A 191
 None
 1.01A 3sj1X-1cjaA:
undetectable		 3sj1X-1cjaA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		5 / 12 HIS A 244
GLY A 245
ARG A 205
ALA A 209
ASP A 197
 None
 1.06A 3sugA-1cjaA:
0.0		 3sugA-1cjaA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJG_B_NCTB501_1
(CYTOCHROME P450 2A13)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 8 PHE A 266
ALA A 195
LEU A 252
LEU A 255
 None
 0.80A 4ejgB-1cjaA:
0.0		 4ejgB-1cjaA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HBF_A_DXCA75_0
(PPCA)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 7 LEU A 255
PHE A 266
MET A 289
GLY A 191
 None
 0.95A 4hbfA-1cjaA:
0.0		 4hbfA-1cjaA:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HC3_A_DXCA75_0
(PPCA)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		4 / 7 LEU A 255
PHE A 266
MET A 289
GLY A 191
 None
 1.01A 4hc3A-1cjaA:
undetectable		 4hc3A-1cjaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IIZ_B_LURB201_1
(TRANSTHYRETIN)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		5 / 8 MET A 162
GLU A 106
ALA A 120
LEU A 118
VAL A 165
 AMP  A 425 (-4.4A)
None
None
None
AMP  A 425 (-4.0A)
 1.33A 4iizB-1cjaA:
undetectable		 4iizB-1cjaA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE0_A_40LA1101_0
(PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT DELTA
ISOFORM)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		5 / 12 THR A 169
ASN A 171
MET A 220
ILE A 231
ASP A 232
 AMP  A 425 ( 4.3A)
None
AMP  A 425 ( 4.0A)
AMP  A 425 (-4.4A)
AMP  A 425 (-2.7A)
 1.47A 4xe0A-1cjaA:
6.9		 4xe0A-1cjaA:
18.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_C_STRC603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		5 / 12 LEU A 153
VAL A 125
ILE A 103
GLY A 133
LEU A 140
 None
 0.95A 4y8wC-1cjaA:
0.1		 4y8wC-1cjaA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HNZ_B_TA1B902_2
(TUBULIN BETA-2B
CHAIN)		 1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)
(Physarum
polycephalum) 		3 / 3 LEU A 170
LEU A 190
ARG A 224
 None
 0.63A 5hnzB-1cjaA:
undetectable		 5hnzB-1cjaA:
24.22