SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cjb'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GX8_A_RTLA1163_0
(BETA-LACTOGLOBULIN)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		5 / 9 LEU A 141
LEU A 135
GLU A  69
ILE A 165
PHE A 156
 None
 1.33A 1gx8A-1cjbA:
0.0		 1gx8A-1cjbA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_2
(DIPEPTIDYL PEPTIDASE
IV)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		3 / 3 ARG A  53
SER A  97
TYR A  96
 None
 0.78A 1x70A-1cjbA:
undetectable		 1x70A-1cjbA:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G2O_A_SAMA500_1
(PCZA361.24)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		3 / 3 ARG A  80
GLU A 144
ASP A 148
 None
IRP  A 300 (-2.8A)
IRP  A 300 (-3.8A)
 0.89A 3g2oA-1cjbA:
undetectable		 3g2oA-1cjbA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_A_1N1A1000_2
(P38A)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		3 / 3 GLU A 144
LEU A 153
LEU A 180
 IRP  A 300 (-2.8A)
None
None
 0.71A 3ohtA-1cjbA:
undetectable		 3ohtA-1cjbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OHT_B_1N1B1000_2
(P38A)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		3 / 3 GLU A 144
LEU A 153
LEU A 180
 IRP  A 300 (-2.8A)
None
None
 0.76A 3ohtB-1cjbA:
undetectable		 3ohtB-1cjbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		4 / 5 SER A 202
TYR A 201
VAL A 143
ASP A 145
 None
None
None
IRP  A 300 (-2.6A)
 1.46A 4eohB-1cjbA:
undetectable		 4eohB-1cjbA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F8H_E_RKEE401_1
(PROTON-GATED ION
CHANNEL)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		4 / 8 VAL A 168
PHE A 184
LEU A 153
ASP A 187
 None
 1.10A 4f8hA-1cjbA:
undetectable
4f8hE-1cjbA:
undetectable		 4f8hA-1cjbA:
20.19
4f8hE-1cjbA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZOW_A_CLMA500_0
(MULTIDRUG
TRANSPORTER MDFA)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		6 / 11 TYR A 159
LEU A 135
LEU A 125
LEU A  75
LEU A  73
ILE A 142
 None
 1.26A 4zowA-1cjbA:
0.1		 4zowA-1cjbA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YF0_A_ACTA504_0
(CARNOSINE
N-METHYLTRANSFERASE)		 1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)
(Plasmodium
falciparum) 		4 / 4 VAL A 218
ASN A 219
LYS A 223
TYR A 226
 None
 1.48A 5yf0A-1cjbA:
0.0		 5yf0A-1cjbA:
19.41