SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cjl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		8 / 10 GLN A  19
GLY A  23
SER A  24
TRP A  26
PHE A  28
SER A  29
HIS A 163
GLY A  77
 None
 0.68A 1stfE-1cjlA:
29.5
1stfI-1cjlA:
0.0		 1stfE-1cjlA:
32.50
1stfI-1cjlA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1502_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		4 / 5 PRO A  83
GLY A  68
ASN A  62
GLY A  61
 None
 1.08A 1zlqA-1cjlA:
undetectable		 1zlqA-1cjlA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J0D_A_ERYA1498_0
(CYTOCHROME P450 3A4)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		5 / 12 ILE A 211
ALA A 125
THR A 128
ALA A   1
ARG A   3
 None
 0.88A 2j0dA-1cjlA:
0.0		 2j0dA-1cjlA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		4 / 7 GLN A  19
GLY A  23
HIS A 163
TRP A 189
 None
 0.35A 3ai8A-1cjlA:
24.8		 3ai8A-1cjlA:
26.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_A_NCTA501_1
(CYTOCHROME P450 2A6)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		4 / 7 PHE A 143
ASN A  76
GLY A 164
ILE A 211
 None
 0.90A 4ejjA-1cjlA:
0.0		 4ejjA-1cjlA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM8_A_RFXA603_1
(TRANSPORTER)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		5 / 12 ALA A  73
TYR A  72
GLY A  86
PHE A 112
ASP A  79
 None
 1.15A 4mm8A-1cjlA:
0.0		 4mm8A-1cjlA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_2
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		4 / 6 ASP A  84
GLU A  35
VAL A 220
ALA A 110
 None
 1.18A 4nkvC-1cjlA:
0.0		 4nkvC-1cjlA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		3 / 3 LEU A  69
ASP A  71
TYR A  72
 None
 0.59A 4qc6B-1cjlA:
0.0		 4qc6B-1cjlA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UAC_A_ACRA501_2
(CARBOHYDRATE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT1 FAMILY
(TC 3.A.1.1.-))		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		4 / 7 GLU A  48
SER A 142
GLU A 153
ASP A 162
 None
 1.23A 4uacA-1cjlA:
0.0		 4uacA-1cjlA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_C_LLLC301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1cjl PROCATHEPSIN L
(Homo
sapiens) 		4 / 6 ASP A  84
TYR A  76
ASP A  55
GLU A  96
 None
 1.48A 6mn5C-1cjlA:
0.0		 6mn5C-1cjlA:
13.14