SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cjx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D0V_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 GLY A 194
GLY A 222
SER A 219
GLY A 224
 None
 0.70A 1d0vA-1cjxA:
undetectable		 1d0vA-1cjxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 GLY A 194
GLY A 222
SER A 219
GLY A 224
 None
 0.74A 1jhqA-1cjxA:
undetectable		 1jhqA-1cjxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 GLY A 194
GLY A 222
SER A 219
GLY A 224
 None
 0.76A 1jhvA-1cjxA:
undetectable		 1jhvA-1cjxA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BJF_A_DXCA330_0
(CHOLOYLGLYCINE
HYDROLASE)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 MET A   8
ASN A  92
ILE A 102
ILE A 104
LEU A  95
 None
 1.33A 2bjfA-1cjxA:
0.0		 2bjfA-1cjxA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HJH_A_NCAA900_0
(NAD-DEPENDENT
HISTONE DEACETYLASE
SIR2)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 PRO A 207
PHE A  82
PHE A 182
ILE A 213
 None
 1.15A 2hjhA-1cjxA:
undetectable		 2hjhA-1cjxA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZZM_A_SAMA401_1
(UNCHARACTERIZED
PROTEIN MJ0883)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 ARG A  83
ASP A 138
ASN A  55
 None
 0.86A 2zzmA-1cjxA:
undetectable		 2zzmA-1cjxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CLD_B_GW6B2_2
(GLUCOCORTICOID
RECEPTOR)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 8 ALA A  94
LEU A  95
TYR A 125
ILE A  65
 None
None
None
EMC  A 630 ( 4.1A)
 0.88A 3cldB-1cjxA:
0.0		 3cldB-1cjxA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_2
(CYTOCHROME P450 2R1)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		3 / 3 LEU A 113
GLU A 110
ILE A 139
 None
 0.59A 3czhA-1cjxA:
0.0		 3czhA-1cjxA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SOA_A_DB8A445_1
(CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II
SUBUNIT ALPHA WITH A
BETA 7 LINKER)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 LEU A 162
VAL A 241
PHE A  18
PHE A  35
 None
 1.06A 3soaA-1cjxA:
0.0		 3soaA-1cjxA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1004_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 GLU A 132
GLY A 131
TYR A 137
GLU A  14
 None
 1.44A 3w9tA-1cjxA:
0.0		 3w9tA-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB502_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 GLU A 283
GLY A 282
LEU A 295
GLU A 275
 None
 1.14A 3w9tB-1cjxA:
0.0		 3w9tB-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 GLU A 132
GLY A 131
TYR A 137
GLU A  14
 None
 1.43A 3w9tC-1cjxA:
0.0		 3w9tC-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD512_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 GLU A 132
GLY A 131
TYR A 137
GLU A  14
 None
 1.43A 3w9tD-1cjxA:
0.0		 3w9tD-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE502_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 GLU A 283
GLY A 282
LEU A 295
GLU A 275
 None
 1.13A 3w9tE-1cjxA:
0.0		 3w9tE-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF503_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 6 GLU A 283
GLY A 282
LEU A 295
GLU A 275
 None
 1.16A 3w9tF-1cjxA:
0.0		 3w9tF-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG502_1
(HEMOLYTIC LECTIN
CEL-III)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 GLU A 132
GLY A 131
TYR A 137
GLU A  14
 None
 1.44A 3w9tG-1cjxA:
0.0		 3w9tG-1cjxA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_B_HAEB1270_1
(COLLAGENASE 3)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 LEU A 294
HIS A 161
GLU A 322
HIS A 240
 None
FE2  A 629 (-3.4A)
FE2  A 629 (-2.5A)
FE2  A 629 (-3.3A)
 1.31A 4a7bB-1cjxA:
undetectable		 4a7bB-1cjxA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 PHE A 321
HIS A 240
PHE A 323
LEU A 340
 None
FE2  A 629 (-3.3A)
None
None
 1.39A 4o8zA-1cjxA:
undetectable		 4o8zA-1cjxA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A 155
ALA A 254
ILE A 310
LEU A 244
LEU A 248
 None
 1.06A 5bw4B-1cjxA:
undetectable		 5bw4B-1cjxA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JNC_D_ACTD305_0
(CARBONIC ANHYDRASE 4)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 ALA A  99
ALA A  94
ILE A 116
LEU A 124
 None
 0.82A 5jncD-1cjxA:
0.0		 5jncD-1cjxA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC3_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 LEU A 255
GLY A  34
GLN A  51
PHE A 323
LEU A 315
 None
 1.44A 5uc3B-1cjxA:
undetectable		 5uc3B-1cjxA:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		4 / 5 GLN A 232
THR A 163
HIS A 240
GLY A 317
 None
ACT  A 631 ( 4.9A)
FE2  A 629 (-3.3A)
None
 1.22A 6gbnC-1cjxA:
undetectable		 6gbnC-1cjxA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MD4_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cjx 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE
(Pseudomonas
fluorescens) 		5 / 12 GLY A  79
CYH A  78
SER A  76
LEU A  26
ILE A  57
 EMC  A 630 ( 4.2A)
EMC  A 630 (-2.4A)
None
None
None
 1.37A 6md4A-1cjxA:
0.0		 6md4A-1cjxA:
15.43