SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ck7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BRP_A_RTLA183_0
(RETINOL BINDING
PROTEIN)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 ALA A 408
MET A 409
MET A 421
LEU A 157
HIS A 403
 None
None
None
None
ZN  A 990 ( 3.4A)
 1.43A 1brpA-1ck7A:
0.3		 1brpA-1ck7A:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DG5_A_TOPA201_1
(DIHYDROFOLATE
REDUCTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 11 ILE A 473
ALA A 635
PHE A 475
PRO A 499
ILE A 468
 None
 1.12A 1dg5A-1ck7A:
undetectable		 1dg5A-1ck7A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OS2_A_HAEA874_1
(MACROPHAGE
METALLOELASTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.41A 1os2A-1ck7A:
28.0		 1os2A-1ck7A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TMX_B_BEZB882_0
(HYDROXYQUINOL
1,2-DIOXYGENASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 GLY A 179
HIS A 193
HIS A 178
HIS A 206
VAL A 201
 None
ZN  A 991 ( 3.1A)
ZN  A 991 ( 3.1A)
ZN  A 991 ( 3.1A)
None
 1.09A 1tmxB-1ck7A:
undetectable		 1tmxB-1ck7A:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Y93_A_HAEA301_1
(MACROPHAGE
METALLOELASTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 6 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.43A 1y93A-1ck7A:
27.8		 1y93A-1ck7A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O7O_A_DXTA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 SER A 246
HIS A 276
PRO A 275
VAL A 221
GLN A 219
 None
 1.34A 2o7oA-1ck7A:
0.1		 2o7oA-1ck7A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OW9_A_HAEA502_1
(COLLAGENASE 3)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 6 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.43A 2ow9A-1ck7A:
27.6		 2ow9A-1ck7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OZR_F_HAEF3004_1
(COLLAGENASE 3)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		3 / 3 HIS A 403
HIS A 407
HIS A 413
 ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.24A 2ozrF-1ck7A:
27.4		 2ozrF-1ck7A:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 8 THR A 339
SER A 344
TYR A 381
TRP A 374
 None
 1.33A 2xz5A-1ck7A:
0.0
2xz5C-1ck7A:
0.0		 2xz5A-1ck7A:
15.12
2xz5C-1ck7A:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A25_A_SAMA279_0
(UNCHARACTERIZED
PROTEIN PH0793)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 PHE A 297
GLY A 318
LYS A 327
ASP A 326
THR A 320
 None
 1.26A 3a25A-1ck7A:
undetectable		 3a25A-1ck7A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BSZ_F_RTLF178_0
(PLASMA
RETINOL-BINDING
PROTEIN)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 11 LEU A 420
ALA A 404
PHE A 207
ALA A 192
TYR A 425
 None
 1.31A 3bszF-1ck7A:
0.2		 3bszF-1ck7A:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_A_D2VA602_1
(CYTOCHROME P450 2R1)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 THR A 580
PHE A 535
ALA A 479
ALA A 570
VAL A 568
 None
None
NA  A 996 (-3.0A)
CL  A 995 ( 4.9A)
None
 1.14A 3czhA-1ck7A:
undetectable		 3czhA-1ck7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 THR A 580
PHE A 535
ALA A 479
ALA A 570
VAL A 568
 None
None
NA  A 996 (-3.0A)
CL  A 995 ( 4.9A)
None
 1.12A 3czhB-1ck7A:
undetectable		 3czhB-1ck7A:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HY7_B_097B801_1
(A DISINTEGRIN AND
METALLOPROTEINASE
WITH THROMBOSPONDIN
MOTIFS 5)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 9 LEU A 191
HIS A 403
HIS A 407
HIS A 413
ILE A 424
 None
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
None
 0.54A 3hy7B-1ck7A:
10.2		 3hy7B-1ck7A:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LIK_A_HAEA302_1
(MACROPHAGE
METALLOELASTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.45A 3likA-1ck7A:
27.8		 3likA-1ck7A:
26.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LKA_A_HAEA269_1
(MACROPHAGE
METALLOELASTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.46A 3lkaA-1ck7A:
27.7		 3lkaA-1ck7A:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8Y_B_SALB900_1
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 VAL A 648
LEU A 640
ILE A 613
ALA A 612
 None
 0.97A 3n8yB-1ck7A:
0.4		 3n8yB-1ck7A:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7B_A_HAEA1273_1
(COLLAGENASE 3)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 6 HIS A 193
HIS A 403
HIS A 407
HIS A 413
 ZN  A 991 ( 3.1A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
ZN  A 990 ( 3.4A)
 0.40A 4a7bA-1ck7A:
27.6		 4a7bA-1ck7A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9L_A_CAMA1419_0
(CYTOCHROME P450)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 THR A  93
LEU A  70
LEU A  74
GLY A  87
ILE A  94
 None
 1.04A 4c9lA-1ck7A:
undetectable		 4c9lA-1ck7A:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4C9O_A_CAMA423_0
(CYTOCHROME P450)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 THR A  93
LEU A  70
LEU A  74
GLY A  87
ILE A  94
 None
 1.03A 4c9oA-1ck7A:
undetectable		 4c9oA-1ck7A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 10 ILE A 473
ALA A 635
PHE A 475
PRO A 499
ILE A 468
 None
 1.03A 4g8zX-1ck7A:
undetectable		 4g8zX-1ck7A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 GLN A 442
THR A 155
LEU A 420
LEU A 433
 None
 1.01A 4lvcB-1ck7A:
undetectable		 4lvcB-1ck7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_A_TMQA202_1
(DIHYDROFOLATE
REDUCTASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 12 ILE A 169
ALA A 194
PHE A 405
LEU A 397
ILE A 171
 None
 0.96A 4m2xA-1ck7A:
undetectable		 4m2xA-1ck7A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OU1_A_BEZA302_0
(RETRO-ALDOLASE,
DESIGN RA114)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 8 TYR A 126
ILE A 128
ILE A 171
ALA A 401
 None
 0.99A 4ou1A-1ck7A:
undetectable		 4ou1A-1ck7A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 ASP A 564
VAL A 568
ASP A 569
GLY A 585
 None
 1.18A 4xp6A-1ck7A:
0.0		 4xp6A-1ck7A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_A_BEZA201_0
(HYDROXYNITRILE LYASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 9 TYR A 581
ILE A 613
PHE A 631
TRP A 574
LEU A 640
 None
 1.44A 5e4dA-1ck7A:
undetectable		 5e4dA-1ck7A:
15.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWK_F_EVPF102_1
(DNA TOPOISOMERASE
2-ALPHA)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 5 GLY A 255
ASP A 254
ARG A 252
MET A 282
 None
 1.47A 5gwkA-1ck7A:
0.0		 5gwkA-1ck7A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 6 PHE A 389
PHE A 184
VAL A  41
ASP A 188
 None
 1.12A 5hesA-1ck7A:
undetectable		 5hesA-1ck7A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_A_ROCA101_1
(PROTEASE PR5-SQV)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 9 ASP A 436
ASP A 437
ILE A 438
THR A 155
PRO A 156
 None
 1.19A 5kr2A-1ck7A:
undetectable		 5kr2A-1ck7A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KR2_C_ROCC101_1
(PROTEASE PR5-SQV)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		5 / 9 ASP A 436
ASP A 437
ILE A 438
THR A 155
PRO A 156
 None
 1.31A 5kr2C-1ck7A:
undetectable		 5kr2C-1ck7A:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5K_B_ADNB502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 4 GLN A 442
THR A 155
LEU A 420
LEU A 433
 None
 1.01A 5m5kB-1ck7A:
undetectable		 5m5kB-1ck7A:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_1
(REGULATORY PROTEIN
TETR)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 8 GLY A  59
GLN A 415
VAL A 107
ASP A 106
 None
 1.00A 5vlmA-1ck7A:
undetectable		 5vlmA-1ck7A:
15.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZRD_A_CUA606_0
(TYROSINASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 4 HIS A 403
CYH A 102
HIS A 413
HIS A 407
 ZN  A 990 ( 3.4A)
ZN  A 990 ( 2.5A)
ZN  A 990 ( 3.4A)
ZN  A 990 ( 3.3A)
 1.50A 5zrdA-1ck7A:
undetectable		 5zrdA-1ck7A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		4 / 9 PHE A 207
VAL A 400
HIS A 403
LEU A 212
 None
None
ZN  A 990 ( 3.4A)
None
 0.96A 6c2mD-1ck7A:
0.3		 6c2mD-1ck7A:
7.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6ESM_A_PZEA307_1
(MATRIX
METALLOPROTEINASE-9,
MATRIX
METALLOPROTEINASE-9)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		3 / 3 TYR A 182
HIS A 193
PHE A 195
 None
ZN  A 991 ( 3.1A)
None
 0.28A 6esmA-1ck7A:
28.0		 6esmA-1ck7A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EXI_C_ADNC502_1
(ADENOSYLHOMOCYSTEINA
SE)		 1ck7 PROTEIN (GELATINASE
A)
(Homo
sapiens) 		3 / 3 LEU A  83
GLY A 505
PHE A 512
 None
 0.66A 6exiC-1ck7A:
undetectable		 6exiC-1ck7A:
8.73