SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ckm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.98A 1dhiA-1ckmA:
undetectable		 1dhiA-1ckmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.98A 1dhiB-1ckmA:
undetectable		 1dhiB-1ckmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.93A 1dhjA-1ckmA:
undetectable		 1dhjA-1ckmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.93A 1dhjB-1ckmA:
undetectable		 1dhjB-1ckmA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.94A 1draA-1ckmA:
undetectable		 1draA-1ckmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.97A 1draB-1ckmA:
undetectable		 1draB-1ckmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.92A 1drbA-1ckmA:
undetectable		 1drbA-1ckmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.93A 1drbB-1ckmA:
undetectable		 1drbB-1ckmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EIZ_A_SAMA301_1
(FTSJ)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ASP A  45
ASP A  49
ASP A  38
 None
 0.60A 1eizA-1ckmA:
undetectable		 1eizA-1ckmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EJ0_A_SAMA301_1
(FTSJ)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ASP A  45
ASP A  49
ASP A  38
 None
 0.64A 1ej0A-1ckmA:
undetectable		 1ej0A-1ckmA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.85A 1rb3B-1ckmA:
undetectable		 1rb3B-1ckmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZGY_A_BRLA503_2
(PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
GAMMA)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 5 ILE A 104
ILE A 118
ILE A 127
MET A  43
 None
 0.78A 1zgyA-1ckmA:
undetectable		 1zgyA-1ckmA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DOU_A_SAMA1_1
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE J)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 ASP A  45
ASP A  49
ASP A  38
 None
 0.52A 3douA-1ckmA:
undetectable		 3douA-1ckmA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.95A 3drcA-1ckmA:
undetectable		 3drcA-1ckmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.97A 3drcB-1ckmA:
undetectable		 3drcB-1ckmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J7Z_A_ERYA9000_0
(23S RRNA
50S RIBOSOMAL
PROTEIN L22
ERMCL NASCENT CHAIN)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		3 / 3 LYS A 234
ILE A 256
PHE A 257
 GTP  A 899 (-2.6A)
None
None
 0.97A 3j7zS-1ckmA:
0.0
3j7za-1ckmA:
undetectable		 3j7zS-1ckmA:
17.48
3j7za-1ckmA:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SJ4_X_DXCX75_0
(CYTOCHROME C7)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 9 ILE A  26
LEU A 113
ILE A 184
PHE A 143
GLY A 130
 None
 1.15A 3sj4X-1ckmA:
undetectable		 3sj4X-1ckmA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 1.01A 4fhbA-1ckmA:
undetectable		 4fhbA-1ckmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 TYR A 226
LEU A  46
VAL A 149
ILE A 127
LEU A  56
 None
 1.38A 4k36A-1ckmA:
undetectable		 4k36A-1ckmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K36_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 TYR A 226
LEU A  46
VAL A 149
ILE A 127
LEU A  56
 None
 1.40A 4k36B-1ckmA:
undetectable		 4k36B-1ckmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_B_SAMB504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 11 TYR A 226
LEU A  46
VAL A 149
ILE A 127
LEU A  56
 None
 1.42A 4k37B-1ckmA:
undetectable		 4k37B-1ckmA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K38_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME
KP18CYS PEPTIDE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 TYR A 226
LEU A  46
VAL A 149
ILE A 127
LEU A  56
 None
 1.36A 4k38A-1ckmA:
undetectable
4k38D-1ckmA:
undetectable		 4k38A-1ckmA:
21.52
4k38D-1ckmA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZAU_A_YY3A1101_1
(EPIDERMAL GROWTH
FACTOR RECEPTOR)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 8 GLY A 268
VAL A 267
LEU A 311
GLY A 283
CYH A 282
 None
 1.18A 4zauA-1ckmA:
undetectable		 4zauA-1ckmA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZJL_D_ERYD1101_0
(MULTIDRUG EFFLUX
PUMP SUBUNIT ACRB)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 SER A  80
PHE A 165
LEU A 235
ASN A 229
GLU A 222
 None
 1.42A 4zjlD-1ckmA:
0.0		 4zjlD-1ckmA:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EML_A_SAMA701_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
5)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		4 / 6 TYR A 111
GLY A  85
GLU A 131
ASP A 213
 None
None
GTP  A 899 (-3.0A)
None
 1.23A 5emlA-1ckmA:
undetectable		 5emlA-1ckmA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 ILE A 318
LEU A 324
ILE A 217
LEU A  72
ILE A  64
 None
 0.94A 5ujxA-1ckmA:
undetectable		 5ujxA-1ckmA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HLP_A_GAWA1501_0
(SUBSTANCE-P
RECEPTOR,SUBSTANCE-P
RECEPTOR)		 1ckm MRNA CAPPING ENZYME
(Paramecium
bursaria
Chlorella
virus
1) 		5 / 12 PRO A 196
ILE A 199
ILE A 198
VAL A  79
ILE A 191
 None
 1.13A 6hlpA-1ckmA:
undetectable		 6hlpA-1ckmA:
22.16