SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cle'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 8 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.66A 1ax9A-1cleA:
42.3		 1ax9A-1cleA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 8 GLY A 124
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.83A 1ax9A-1cleA:
42.3		 1ax9A-1cleA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 ILE A 453
TYR A 467
PHE A 471
PHE A 434
 CLL  A 801 (-3.9A)
None
None
None
 1.04A 1e71M-1cleA:
1.4		 1e71M-1cleA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 ILE A 453
TYR A 467
PHE A 471
PHE A 434
 CLL  A 801 (-3.9A)
None
None
None
 1.02A 1e72M-1cleA:
undetectable		 1e72M-1cleA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GXS_A_BEZA601_0
(P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
A
P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 GLY A 242
ASP A 452
SER A 212
ALA A 450
 None
None
None
CLL  A 801 (-3.4A)
 0.96A 1gxsA-1cleA:
6.8
1gxsB-1cleA:
1.0		 1gxsA-1cleA:
19.81
1gxsB-1cleA:
15.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 8 GLY A 123
GLU A 208
SER A 209
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.8A)
 0.42A 1maaD-1cleA:
37.0		 1maaD-1cleA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 8 GLY A 124
GLU A 208
SER A 209
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.8A)
 0.85A 1maaD-1cleA:
37.0		 1maaD-1cleA:
31.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 GLY A 123
GLY A 124
SER A 209
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 0.49A 1mx1D-1cleA:
40.3		 1mx1D-1cleA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		6 / 12 GLY A 123
GLY A 124
SER A 209
LEU A 304
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.7A)
None
CLL  A 801 (-4.8A)
 0.71A 1mx1F-1cleA:
39.8		 1mx1F-1cleA:
30.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		8 / 12 GLY A 122
GLY A 123
GLY A 124
GLU A 208
SER A 209
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.28A 1qtiA-1cleA:
43.0		 1qtiA-1cleA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZZ_A_SAMA635_0
(ACLACINOMYCIN-10-HYD
ROXYLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 TYR A 156
GLY A 124
LEU A 297
PRO A  65
PHE A 345
 None
CLL  A 801 (-3.3A)
None
None
CLL  A 801 ( 4.9A)
 1.16A 1qzzA-1cleA:
undetectable		 1qzzA-1cleA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SGU_B_MK1B2632_1
(POL POLYPROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 8 ALA A   4
ILE A 193
GLY A 198
GLY A 197
ALA A  22
 None
None
None
None
PO4  A 601 (-2.9A)
 1.18A 1sguA-1cleA:
0.0		 1sguA-1cleA:
10.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		7 / 12 GLY A 122
GLY A 123
GLY A 124
SER A 209
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.31A 1w6rA-1cleA:
43.0		 1w6rA-1cleA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		6 / 10 GLY A 122
GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.33A 1w76B-1cleA:
43.4		 1w76B-1cleA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 10 GLY A 123
GLY A 124
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 1.05A 1w76B-1cleA:
43.4		 1w76B-1cleA:
31.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 1.00A 1ya4A-1cleA:
43.0		 1ya4A-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 1.06A 1ya4C-1cleA:
39.8		 1ya4C-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		6 / 8 GLY A 122
GLY A 123
GLY A 124
SER A 209
ALA A 210
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
CLL  A 801 (-4.8A)
 0.39A 1yajC-1cleA:
39.2		 1yajC-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 8 GLY A 123
GLY A 124
SER A 209
ALA A 210
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
CLL  A 801 (-4.8A)
 0.75A 1yajC-1cleA:
39.2		 1yajC-1cleA:
30.38
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		6 / 8 GLY A 211
GLY A 122
GLY A 123
SER A 209
ALA A 210
HIS A 449
 None
CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
CLL  A 801 (-4.8A)
 1.23A 1yajC-1cleA:
39.2		 1yajC-1cleA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 11 SER A 365
VAL A 534
LEU A 304
LEU A 410
TYR A 361
 CLL  A 801 (-3.3A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.7A)
CLL  A 801 (-4.5A)
CLL  A 801 ( 4.8A)
 1.18A 2a15A-1cleA:
0.0		 2a15A-1cleA:
14.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		7 / 9 GLY A 123
GLY A 124
SER A 209
ALA A 210
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.32A 2aceA-1cleA:
44.6		 2aceA-1cleA:
31.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 7 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.70A 2ackA-1cleA:
43.2		 2ackA-1cleA:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_A_1FLA2003_1
(SERUM ALBUMIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 9 LEU A 377
PHE A 362
LEU A 525
HIS A 417
ALA A 408
 None
 1.08A 2bxeA-1cleA:
2.7		 2bxeA-1cleA:
21.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 8 GLY A 123
GLY A 124
ALA A 210
PHE A 345
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-4.0A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-4.8A)
 0.98A 2ha4A-1cleA:
40.4		 2ha4A-1cleA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 8 GLY A 123
GLY A 124
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.35A 2ha4A-1cleA:
40.4		 2ha4A-1cleA:
31.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_B_ACTB601_0
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 GLY A 123
GLY A 124
ALA A 210
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-4.0A)
CLL  A 801 (-4.8A)
 0.24A 2ha4B-1cleA:
42.6		 2ha4B-1cleA:
31.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VH3_B_DAHB2_1
(RANASMURFIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 8 ALA A 276
GLY A 267
SER A 280
ALA A 281
 None
 0.87A 2vh3B-1cleA:
0.0		 2vh3B-1cleA:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 ILE A 169
GLY A 255
GLY A 252
ASP A 248
TYR A 259
 None
 1.24A 2zw9A-1cleA:
2.6		 2zw9A-1cleA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EL4_A_ROCA100_2
(PROTEASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 9 ALA A   4
VAL A 102
ILE A 193
GLY A 197
PRO A 105
 None
 1.18A 3el4B-1cleA:
undetectable		 3el4B-1cleA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 11 GLN A 456
SER A 214
TRP A 119
GLY A 207
GLY A 211
 None
 1.15A 3gy3A-1cleA:
undetectable		 3gy3A-1cleA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 GLY A 242
PHE A 415
PHE A 296
PHE A 345
 None
None
CLL  A 801 (-3.7A)
CLL  A 801 ( 4.9A)
 0.90A 3ko0D-1cleA:
1.9
3ko0E-1cleA:
2.0		 3ko0D-1cleA:
10.15
3ko0E-1cleA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 GLY A 123
MET A 445
PHE A 403
PHE A 345
 CLL  A 801 (-3.3A)
None
None
CLL  A 801 ( 4.9A)
 0.99A 3ko0L-1cleA:
2.3
3ko0N-1cleA:
2.3		 3ko0L-1cleA:
10.15
3ko0N-1cleA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_L_TFPL201_1
(PROTEIN S100-A4)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 GLY A 124
MET A 445
PHE A 403
PHE A 345
 CLL  A 801 (-3.3A)
None
None
CLL  A 801 ( 4.9A)
 1.03A 3ko0L-1cleA:
2.3
3ko0N-1cleA:
2.3		 3ko0L-1cleA:
10.15
3ko0N-1cleA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_S_TFPS201_1
(PROTEIN S100-A4)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 PHE A 345
GLY A 123
MET A 445
PHE A 403
 CLL  A 801 ( 4.9A)
CLL  A 801 (-3.3A)
None
None
 1.09A 3ko0K-1cleA:
2.1
3ko0S-1cleA:
2.2		 3ko0K-1cleA:
10.15
3ko0S-1cleA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT201_1
(PROTEIN S100-A4)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 7 PHE A 345
GLY A 123
MET A 445
PHE A 403
 CLL  A 801 ( 4.9A)
CLL  A 801 (-3.3A)
None
None
 1.09A 3ko0R-1cleA:
2.3
3ko0T-1cleA:
2.3		 3ko0R-1cleA:
10.15
3ko0T-1cleA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 7 GLY A 122
GLY A 123
SER A 209
PHE A 415
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
CLL  A 801 (-4.8A)
 1.40A 3o9mA-1cleA:
43.9		 3o9mA-1cleA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		6 / 7 GLY A 123
GLY A 124
SER A 209
LEU A 302
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
None
CLL  A 801 (-4.8A)
 0.52A 3o9mA-1cleA:
43.9		 3o9mA-1cleA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 6 GLY A 123
GLY A 124
SER A 209
LEU A 302
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
CLL  A 801 (-4.8A)
 0.60A 3o9mB-1cleA:
43.7		 3o9mB-1cleA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 LEU A 377
VAL A 534
ILE A 406
VAL A 409
LEU A 410
 None
CLL  A 801 ( 4.9A)
None
None
CLL  A 801 (-4.5A)
 1.05A 3w67B-1cleA:
undetectable		 3w67B-1cleA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 6 TYR A 467
GLN A 240
ASP A 457
GLN A 137
 None
 1.30A 4azvA-1cleA:
undetectable		 4azvA-1cleA:
21.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		7 / 12 GLY A 122
GLY A 123
GLY A 124
SER A 209
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.33A 4ey6A-1cleA:
42.7		 4ey6A-1cleA:
30.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		8 / 12 GLY A 122
GLY A 123
GLY A 124
GLU A 208
SER A 209
PHE A 345
PHE A 296
HIS A 449
 CLL  A 801 (-4.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 (-3.4A)
CLL  A 801 ( 2.8A)
CLL  A 801 ( 4.9A)
CLL  A 801 (-3.7A)
CLL  A 801 (-4.8A)
 1.31A 4ey6B-1cleA:
37.6		 4ey6B-1cleA:
30.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 5 ILE A  12
LEU A   6
LYS A   5
ASN A  49
 None
 1.11A 4g19A-1cleA:
0.0		 4g19A-1cleA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 6 ILE A 334
GLY A 336
ILE A 453
ILE A 466
 None
None
CLL  A 801 (-3.9A)
None
 0.76A 4o8fB-1cleA:
0.0		 4o8fB-1cleA:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PEV_A_ADNA501_2
(MEMBRANE LIPOPROTEIN
FAMILY PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		3 / 3 PRO A  65
LEU A 297
HIS A 449
 None
None
CLL  A 801 (-4.8A)
 0.68A 4pevA-1cleA:
2.4		 4pevA-1cleA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HW8_G_FK5G201_1
(FK506-BINDING
PROTEIN 1)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		3 / 3 ILE A  26
PRO A  27
ILE A 100
 None
 0.45A 5hw8F-1cleA:
0.0		 5hw8F-1cleA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A210_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 12 LEU A 302
VAL A 344
PHE A 345
TYR A 156
GLY A 122
 CLL  A 801 (-4.0A)
None
CLL  A 801 ( 4.9A)
None
CLL  A 801 (-4.3A)
 1.40A 5i8fA-1cleA:
0.0		 5i8fA-1cleA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		3 / 3 ILE A 466
ILE A 238
MET A 503
 None
 0.63A 5i9yA-1cleA:
undetectable		 5i9yA-1cleA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		3 / 3 ASP A 412
PHE A 517
ARG A 419
 None
 0.90A 5yw0A-1cleA:
0.0		 5yw0A-1cleA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		3 / 3 ASP A 412
PHE A 517
ARG A 420
 None
 1.15A 5yw0A-1cleA:
0.0		 5yw0A-1cleA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 6 ALA A 369
SER A 531
ALA A 372
SER A 370
 None
 1.04A 6bocA-1cleA:
undetectable
6bocB-1cleA:
undetectable
6bocC-1cleA:
undetectable
6bocD-1cleA:
undetectable		 6bocA-1cleA:
7.72
6bocB-1cleA:
7.72
6bocC-1cleA:
7.72
6bocD-1cleA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HZP_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		4 / 8 TYR A 156
GLN A  62
PRO A 130
ILE A 132
 None
None
None
CLL  A 801 (-4.1A)
 1.11A 6hzpA-1cleA:
undetectable		 6hzpA-1cleA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 11 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.97A 6qgbA-1cleA:
10.2		 6qgbA-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 10 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.97A 6qgbB-1cleA:
10.1		 6qgbB-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 9 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.97A 6qgbC-1cleA:
10.2		 6qgbC-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 10 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.97A 6qgbD-1cleA:
2.6		 6qgbD-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 11 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.95A 6qgbE-1cleA:
10.7		 6qgbE-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 10 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
None
None
CLL  A 801 (-4.8A)
 0.96A 6qgbF-1cleA:
10.0		 6qgbF-1cleA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6R2E_C_FFOC404_0
(THYMIDYLATE SYNTHASE)		 1cle CHOLESTEROL ESTERASE
([Candida]
cylindracea) 		5 / 10 PHE A 121
ILE A 120
LEU A 219
LEU A 118
MET A 186
 None
 1.43A 6r2eC-1cleA:
0.0		 6r2eC-1cleA:
20.22