SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cli'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A  63
LEU A  95
GLY A 158
PHE A 105
VAL A 230
 None
 1.24A 1fduC-1cliA:
undetectable		 1fduC-1cliA:
25.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 GLY A  84
GLY A  68
LEU A  71
SER A 191
GLY A  66
 None
SO4  A4350 ( 3.9A)
None
None
None
 1.09A 1jhyA-1cliA:
undetectable		 1jhyA-1cliA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_B_FUAB703_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A  88
ALA A  89
HIS A 190
 None
 0.54A 1q23C-1cliA:
0.0		 1q23C-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_G_FUAG708_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A  88
ALA A  89
HIS A 190
 None
 0.51A 1q23H-1cliA:
0.0		 1q23H-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_I_FUAI707_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A  88
ALA A  89
HIS A 190
 None
 0.61A 1q23G-1cliA:
0.0		 1q23G-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_K_FUAK712_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A  88
ALA A  89
HIS A 190
 None
 0.61A 1q23L-1cliA:
0.0		 1q23L-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_L_FUAL710_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 VAL A  88
ALA A  89
HIS A 190
 None
 0.54A 1q23J-1cliA:
0.0		 1q23J-1cliA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2GJ5_A_VD3A163_1
(BETA-LACTOGLOBULIN)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 VAL A 240
VAL A 242
ILE A 306
LEU A 308
ILE A 182
 None
 0.81A 2gj5A-1cliA:
0.0		 2gj5A-1cliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2P16_A_GG2A298_2
(COAGULATION FACTOR X
(EC 3.4.21.6)
(STUART FACTOR)
(STUART-PROWER
FACTOR))		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ARG A 341
GLU A 339
GLN A 340
 None
 0.90A 2p16A-1cliA:
0.0		 2p16A-1cliA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 ALA A 318
LEU A 319
LEU A 236
ILE A 182
VAL A 242
 None
 1.18A 2uxpA-1cliA:
0.0		 2uxpA-1cliA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A50_D_VD3D2001_1
(VITAMIN D
HYDROXYLASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 ILE A  26
LEU A  22
ILE A 126
ALA A 127
THR A  33
 None
 1.09A 3a50D-1cliA:
undetectable		 3a50D-1cliA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3H5G_C_LEIC16_0
(COIL SER L16D-PEN)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 LEU A 103
GLN A  53
LEU A  51
GLU A  37
 None
 1.01A 3h5gB-1cliA:
undetectable
3h5gC-1cliA:
undetectable		 3h5gB-1cliA:
8.37
3h5gC-1cliA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R9S_A_BEZA264_0
(CARNITINYL-COA
DEHYDRATASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 6 ALA A 307
ILE A 333
LEU A 181
ALA A 246
 None
 0.91A 3r9sA-1cliA:
undetectable		 3r9sA-1cliA:
24.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_A_TPVA100_2
(HIV-1 PROTEASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 LEU A 137
ALA A  47
GLY A  40
THR A  33
 None
 0.83A 3spkB-1cliA:
undetectable		 3spkB-1cliA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UJ6_A_SAMA300_1
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 4 SER A 186
ASP A  86
ASP A  81
ALA A 224
 None
 1.28A 3uj6A-1cliA:
undetectable		 3uj6A-1cliA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 TRP A 274
VAL A 279
TRP A 276
 None
 1.13A 3zq8C-1cliA:
undetectable
3zq8D-1cliA:
undetectable		 3zq8C-1cliA:
3.95
3zq8D-1cliA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6E_A_SAMA1349_1
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 TYR A 194
ASP A  86
ASP A  65
 None
 0.88A 4a6eA-1cliA:
undetectable		 4a6eA-1cliA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 8 ILE A 123
ILE A 126
PHE A 105
VAL A 156
GLY A 158
 None
 1.07A 4ac9C-1cliA:
undetectable		 4ac9C-1cliA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 ILE A 123
ILE A 126
PHE A 105
GLY A 158
 None
 0.82A 4acaC-1cliA:
undetectable		 4acaC-1cliA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1475_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 ILE A 123
ILE A 126
PHE A 105
GLY A 158
 None
 0.77A 4acbC-1cliA:
undetectable		 4acbC-1cliA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYZ_B_CCSB109_0
(CELLULOSOME-RELATED
PROTEIN MODULE FROM
RUMINOCOCCUS
FLAVEFACIENS THAT
RESEMBLES
PAPAIN-LIKE CYSTEINE
PEPTIDASES)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 TYR A 109
VAL A  67
ILE A  83
ALA A 121
 None
 1.02A 4eyzB-1cliA:
0.0		 4eyzB-1cliA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4HB6_A_DXCA75_0
(PPCA)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 8 ILE A 257
LEU A 261
ILE A 306
GLY A 178
 None
 0.86A 4hb6A-1cliA:
undetectable		 4hb6A-1cliA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KQI_A_NIOA403_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 9 GLY A  84
GLY A  68
LEU A  71
SER A 191
GLY A  66
 None
SO4  A4350 ( 3.9A)
None
None
None
 1.09A 4kqiA-1cliA:
undetectable		 4kqiA-1cliA:
24.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE3_A_CL6A502_1
(CYTOCHROME P-450)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 5 LEU A 184
ALA A 246
VAL A 242
ILE A 170
 None
 0.97A 4xe3A-1cliA:
0.0		 4xe3A-1cliA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XO7_B_ASDB402_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 TYR A 194
VAL A  67
ILE A  85
LEU A  77
 None
 0.94A 4xo7B-1cliA:
undetectable		 4xo7B-1cliA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_A_STRA604_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 VAL A 302
ASP A 270
ILE A 330
GLY A 331
VAL A 313
 None
 1.09A 4y8wA-1cliA:
0.0		 4y8wA-1cliA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y8W_B_STRB603_1
(CYTOCHROME P450
21-HYDROXYLASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 VAL A 302
ASP A 270
ILE A 330
GLY A 331
VAL A 313
 None
 1.10A 4y8wB-1cliA:
undetectable		 4y8wB-1cliA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 LEU A 222
PRO A 189
LEU A  73
TYR A 194
 None
 1.02A 4z4fA-1cliA:
2.0		 4z4fA-1cliA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KBW_A_RBFA201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 LEU A 184
GLY A 324
ASN A 323
LEU A 319
ALA A 316
 None
 1.42A 5kbwA-1cliA:
undetectable		 5kbwA-1cliA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MUE_A_VIVA302_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		6 / 12 VAL A 302
ILE A 257
VAL A 260
LEU A 261
VAL A 175
ILE A 333
 None
 1.27A 5mueA-1cliA:
0.0		 5mueA-1cliA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		4 / 7 LEU A 222
PRO A 189
LEU A  73
TYR A 194
 None
 1.02A 5t7bA-1cliA:
0.0		 5t7bA-1cliA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_1
(CYTOCHROME P450 3A5)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		6 / 12 LEU A  22
GLY A  44
ILE A 123
ALA A 127
THR A  33
GLY A  41
 None
 1.28A 5veuH-1cliA:
0.0		 5veuH-1cliA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_C_SAMC601_0
(NS5
METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 162
GLU A 165
ASP A 241
VAL A 242
ILE A 170
 None
 0.92A 5wz1C-1cliA:
undetectable		 5wz1C-1cliA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_D_SAMD601_0
(NS5
METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 162
GLU A 165
ASP A 241
VAL A 242
ILE A 170
 None
 0.96A 5wz1D-1cliA:
undetectable		 5wz1D-1cliA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_E_SAME601_0
(NS5
METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 162
GLU A 165
ASP A 241
VAL A 242
ILE A 170
 None
 0.90A 5wz1E-1cliA:
undetectable		 5wz1E-1cliA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_F_SAMF601_0
(NS5
METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 162
GLU A 165
ASP A 241
VAL A 242
ILE A 170
 None
 0.97A 5wz1F-1cliA:
undetectable		 5wz1F-1cliA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WZ1_H_SAMH601_0
(NS5
METHYLTRANSFERASE)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		5 / 12 GLY A 162
GLU A 165
ASP A 241
VAL A 242
ILE A 170
 None
 0.94A 5wz1H-1cliA:
undetectable		 5wz1H-1cliA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZMQ_K_PACK1_0
(SERINE PROTEASE NS3
PEPTIDE
PAC-DLY-DLY-DAR)		 1cli PROTEIN
(PHOSPHORIBOSYL-AMIN
OIMIDAZOLE
SYNTHETASE)
(Escherichia
coli) 		3 / 3 ALA A 121
VAL A 156
TYR A 109
 None
 0.64A 5zmqH-1cliA:
0.0		 5zmqH-1cliA:
22.55