SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1clx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AXW_B_MTXB733_1
(THYMIDYLATE SYNTHASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		5 / 11 ILE A  32
ASP A 309
LEU A 325
PHE A 327
TYR A 315
 None
 1.45A 1axwB-1clxA:
0.0		 1axwB-1clxA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_C_DVAC8_0
(GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 4 VAL A 124
TRP A  83
TRP A 122
 None
 1.28A 1gmkC-1clxA:
undetectable
1gmkD-1clxA:
undetectable		 1gmkC-1clxA:
8.70
1gmkD-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WSV_A_THHA3001_1
(AMINOMETHYLTRANSFERA
SE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 ASP A 134
GLU A 246
TYR A 178
 None
 0.82A 1wsvA-1clxA:
0.0		 1wsvA-1clxA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_A_DVAA8_0
(GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 VAL A 249
TRP A 305
TRP A 313
 None
 1.31A 2xdcA-1clxA:
undetectable
2xdcB-1clxA:
undetectable		 2xdcA-1clxA:
8.70
2xdcB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XDC_B_DVAB8_0
(GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 TRP A 313
VAL A 249
TRP A 305
 None
 1.32A 2xdcA-1clxA:
undetectable
2xdcB-1clxA:
undetectable		 2xdcA-1clxA:
8.70
2xdcB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 VAL A 249
TRP A 305
TRP A 313
 None
 1.31A 2y5mA-1clxA:
undetectable
2y5mB-1clxA:
undetectable		 2y5mA-1clxA:
8.70
2y5mB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y5M_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 4 VAL A 304
TRP A 313
VAL A 249
TRP A 305
 None
 1.39A 2y5mA-1clxA:
undetectable
2y5mB-1clxA:
undetectable		 2y5mA-1clxA:
8.70
2y5mB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 VAL A 249
TRP A 305
TRP A 313
 None
 1.31A 2y6nA-1clxA:
undetectable
2y6nB-1clxA:
undetectable		 2y6nA-1clxA:
8.70
2y6nB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6N_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 TRP A 313
VAL A 249
TRP A 305
 None
 1.31A 2y6nA-1clxA:
undetectable
2y6nB-1clxA:
undetectable		 2y6nA-1clxA:
8.70
2y6nB-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_B_SAMB801_0
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		5 / 12 GLY A 275
ASP A 277
LEU A 251
ASP A 256
ASN A 258
 None
None
None
CA  A 348 (-2.3A)
None
 1.15A 2zw9B-1clxA:
undetectable		 2zw9B-1clxA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UA5_A_06XA501_1
(CYTOCHROME P450 2B6)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 8 ILE A 160
ILE A 207
PHE A 164
LEU A 193
 None
 0.82A 3ua5A-1clxA:
0.0		 3ua5A-1clxA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_A_DVAA8_0
(VAL-GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 VAL A 249
TRP A 305
TRP A 313
 None
 1.33A 3zq8A-1clxA:
undetectable
3zq8B-1clxA:
undetectable		 3zq8A-1clxA:
8.70
3zq8B-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_D_DVAD8_0
(VAL-GRAMICIDIN A)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 TRP A 313
VAL A 304
TRP A 305
 None
 0.99A 3zq8C-1clxA:
undetectable
3zq8D-1clxA:
undetectable		 3zq8C-1clxA:
8.70
3zq8D-1clxA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DT8_A_ADNA401_1
(APH(2'')-ID)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		5 / 11 GLY A 339
ALA A 343
ILE A 244
LEU A 247
ILE A 286
 None
 1.09A 4dt8A-1clxA:
undetectable		 4dt8A-1clxA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ENH_A_FVXA602_1
(CHOLESTEROL
24-HYDROXYLASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		5 / 12 LEU A  65
ILE A  45
ALA A  13
ALA A  21
ALA A  16
 None
 0.78A 4enhA-1clxA:
0.0		 4enhA-1clxA:
23.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EYR_B_RITB301_1
(HIV-1 PROTEASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 7 LEU A   2
ALA A   6
ASP A   7
ILE A 242
 None
 0.99A 4eyrA-1clxA:
0.0		 4eyrA-1clxA:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_A_20JA602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 7 TYR A 283
VAL A 216
ILE A 226
ILE A 223
 None
 0.80A 4lv9A-1clxA:
2.7		 4lv9A-1clxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 7 TYR A 283
VAL A 216
ILE A 226
ILE A 223
 None
 0.82A 4lv9B-1clxA:
2.9		 4lv9B-1clxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLT_A_GCSA306_1
(CHITOSANASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 SER A 312
ASP A 309
GLN A 279
 None
 0.86A 4oltA-1clxA:
0.0
4oltB-1clxA:
0.0		 4oltA-1clxA:
20.74
4oltB-1clxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_B_GCSB304_1
(CHITOSANASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		3 / 3 GLN A 279
SER A 312
ASP A 309
 None
 0.80A 4qwpA-1clxA:
0.0
4qwpB-1clxA:
0.0		 4qwpA-1clxA:
20.74
4qwpB-1clxA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XV2_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 4 GLY A  19
LEU A 331
PHE A 327
ILE A 307
 None
 0.97A 4xv2A-1clxA:
0.0		 4xv2A-1clxA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MSD_A_BEZA1202_0
(CARBOXYLIC ACID
REDUCTASE)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		4 / 5 HIS A 107
ILE A 108
PHE A 150
ALA A 163
 None
 1.26A 5msdA-1clxA:
2.6		 5msdA-1clxA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_A_PFLA412_1
(PROTON-GATED ION
CHANNEL)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		5 / 10 TYR A 178
ILE A 233
ILE A 242
VAL A 197
TYR A 177
 None
 1.10A 5mzrA-1clxA:
0.0		 5mzrA-1clxA:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_C_PFLC409_1
(PROTON-GATED ION
CHANNEL)		 1clx XYLANASE A
(Cellvibrio
japonicus) 		5 / 10 TYR A 178
ILE A 233
ILE A 242
VAL A 197
TYR A 177
 None
 1.12A 5mzrC-1clxA:
0.0		 5mzrC-1clxA:
10.66