SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cm0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z95_A_198A501_2
(ANDROGEN RECEPTOR)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		4 / 6 LEU B 603
ASN B 604
LEU B 593
ILE B 571
 None
 0.86A 1z95A-1cm0B:
0.0		 1z95A-1cm0B:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CR5_X_PNTX95_0
(PROTEIN S100-B)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		3 / 3 CYH B 574
PHE B 573
PHE B 522
 COA  B 700 (-3.1A)
None
None
 1.01A 3cr5X-1cm0B:
undetectable		 3cr5X-1cm0B:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OKW_A_198A1001_2
(ANDROGEN RECEPTOR)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		4 / 7 LEU B 603
ASN B 604
LEU B 593
ILE B 571
 None
 0.85A 4okwA-1cm0B:
0.0		 4okwA-1cm0B:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		3 / 3 PRO B 530
MET B 529
TYR B 533
 None
 0.95A 4qa0B-1cm0B:
0.0		 4qa0B-1cm0B:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		3 / 3 PRO B 530
MET B 529
TYR B 533
 None
 0.99A 4qa0A-1cm0B:
undetectable		 4qa0A-1cm0B:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_A_SHHA404_2
(HISTONE DEACETYLASE
8)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		3 / 3 PRO B 530
MET B 529
TYR B 533
 None
 1.03A 4qa2B-1cm0B:
undetectable		 4qa2B-1cm0B:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X66_F_MTXF402_1
(THYMIDYLATE SYNTHASE)		 1cm0 P300/CBP ASSOCIATING
FACTOR
(Homo
sapiens) 		5 / 12 ILE B 549
LEU B 518
GLY B 517
ALA B 575
VAL B 576
 None
None
None
COA  B 700 (-3.7A)
COA  B 700 (-4.2A)
 0.85A 5x66F-1cm0B:
0.0		 5x66F-1cm0B:
19.86