SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cmv'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1IGX_A_EPAA700_2 (PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	4 / 8	VAL A 158 VAL A 14 VAL A 16 LEU A 160	None	0.84A	1igxA-1cmvA: 0.0	1igxA-1cmvA: 18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1JIN_A_KTNA801_1 (CYTOCHROME P450 107A1)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	5 / 11	ALA A 171 TYR A 173 VAL A 69 LEU A 59 LEU A 131	None	1.08A	1jinA-1cmvA: 0.0	1jinA-1cmvA: 24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1N2X_B_SAMB402_1 (S-ADENOSYL-METHYLTRA NSFERASE MRAW)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	4 / 5	ASP A 227 VAL A 226 SER A 225 ASP A 64	None	1.47A	1n2xB-1cmvA: undetectable	1n2xB-1cmvA: 23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2PO5_B_CHDB502_0 (FERROCHELATASE, MITOCHONDRIAL)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	4 / 8	LEU A 131 LEU A 124 VAL A 69 GLY A 70	None	0.96A	2po5B-1cmvA: undetectable	2po5B-1cmvA: 22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3SUE_D_SUED1201_2 (NS3 PROTEASE, NS4A PROTEIN)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	3 / 3	TYR A 128 LEU A 244 LYS A 242	None	0.66A	3sueD-1cmvA: 0.0	3sueD-1cmvA: 22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4KLR_B_CHDB504_0 (FERROCHELATASE, MITOCHONDRIAL)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	3 / 3	LEU A 57 PRO A 58 ARG A 166	None	0.57A	4klrB-1cmvA: undetectable	4klrB-1cmvA: 21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4QD3_A_5AEA201_1 (PEPTIDYL-TRNA HYDROLASE)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	5 / 9	LEU A 187 GLY A 194 VAL A 78 SER A 77 LEU A 82	None	1.11A	4qd3A-1cmvA: undetectable	4qd3A-1cmvA: 25.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5X7F_A_SAMA301_0 (PUTATIVE O-METHYLTRANSFERASE RV1220C)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	5 / 12	GLY A 168 GLY A 130 GLY A 164 ALA A 171 TYR A 173	None	0.90A	5x7fA-1cmvA: undetectable	5x7fA-1cmvA: 22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	6D9K_F_ACTF802_0 (UNCHARACTERIZED PROTEIN)	1cmv	HUMAN CYTOMEGALOVIRUS PROTEASE (Human betaherpesvirus 5)	3 / 3	TYR A 128 ALA A 67 LEU A 221	None	0.74A	6d9kF-1cmvA: undetectable	6d9kF-1cmvA: 20.17

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1IGX_A_EPAA700_2","PROSTAGLANDIN ENDOPEROXIDE H SYNTHASE-1","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",4,"VAL A 158;VAL A  14;VAL A  16;LEU A 160","None","0.84A","1igxA-1cmvA:0.0","1igxA-1cmvA:18.29"],["1JIN_A_KTNA801_1","CYTOCHROME P450 107A1","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",5,"ALA A 171;TYR A 173;VAL A  69;LEU A  59;LEU A 131","None","1.08A","1jinA-1cmvA:0.0","1jinA-1cmvA:24.03"],["1N2X_B_SAMB402_1","S-ADENOSYL-METHYLTRANSFERASE MRAW","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",4,"ASP A 227;VAL A 226;SER A 225;ASP A  64","None","1.47A","1n2xB-1cmvA:undetectable","1n2xB-1cmvA:23.15"],["2PO5_B_CHDB502_0","FERROCHELATASE, MITOCHONDRIAL","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",4,"LEU A 131;LEU A 124;VAL A  69;GLY A  70","None","0.96A","2po5B-1cmvA:undetectable","2po5B-1cmvA:22.16"],["3SUE_D_SUED1201_2","NS3 PROTEASE, NS4A PROTEIN","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",3,"TYR A 128;LEU A 244;LYS A 242","None","0.66A","3sueD-1cmvA:0.0","3sueD-1cmvA:22.27"],["4KLR_B_CHDB504_0","FERROCHELATASE, MITOCHONDRIAL","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",3,"LEU A  57;PRO A  58;ARG A 166","None","0.57A","4klrB-1cmvA:undetectable","4klrB-1cmvA:21.18"],["4QD3_A_5AEA201_1","PEPTIDYL-TRNA HYDROLASE","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",5,"LEU A 187;GLY A 194;VAL A  78;SER A  77;LEU A  82","None","1.11A","4qd3A-1cmvA:undetectable","4qd3A-1cmvA:25.66"],["5X7F_A_SAMA301_0","PUTATIVE O-METHYLTRANSFERASE RV1220C","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",5,"GLY A 168;GLY A 130;GLY A 164;ALA A 171;TYR A 173","None","0.90A","5x7fA-1cmvA:undetectable","5x7fA-1cmvA:22.76"],["6D9K_F_ACTF802_0","UNCHARACTERIZED PROTEIN","1cmv","HUMAN CYTOMEGALOVIRUS PROTEASE","Human betaherpesvirus 5",3,"TYR A 128;ALA A  67;LEU A 221","None","0.74A","6d9kF-1cmvA:undetectable","6d9kF-1cmvA:20.17"]]