SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cmx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4Y_A_TPVA501_2
(PROTEIN (HIV-1
PROTEASE))		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 8 ARG A 208
LEU A  39
GLY A 232
ILE A  36
 None
 0.53A 1d4yB-1cmxA:
undetectable		 1d4yB-1cmxA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FXH_B_PACB1001_0
(PENICILLIN ACYLASE)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 7 PHE A 115
SER A 124
PHE A 129
SER A 120
 None
 0.84A 1fxhA-1cmxA:
0.0
1fxhB-1cmxA:
0.0		 1fxhA-1cmxA:
19.43
1fxhB-1cmxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HK2_A_T44A3002_1
(SERUM ALBUMIN)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 8 GLN A 119
LEU A 116
LEU A  96
TYR A  93
 None
 0.72A 1hk2A-1cmxA:
undetectable		 1hk2A-1cmxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PNL_B_PACB559_0
(PENICILLIN
AMIDOHYDROLASE)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 8 PHE A 115
SER A 124
PHE A 129
SER A 120
 None
 0.80A 1pnlA-1cmxA:
undetectable
1pnlB-1cmxA:
0.2		 1pnlA-1cmxA:
19.43
1pnlB-1cmxA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_C_FUAC701_2
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		5 / 12 THR A 169
SER A  98
LEU A  25
VAL A 141
PHE A 137
 None
 1.27A 1q23C-1cmxA:
0.0		 1q23C-1cmxA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QLT_B_ACTB601_0
(VANILLYL-ALCOHOL
OXIDASE)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 5 TYR A 214
ILE A 168
TYR A 170
ARG A 210
 None
 1.42A 1qltB-1cmxA:
0.0		 1qltB-1cmxA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		3 / 3 ASN A 225
ASN A  62
GLU A 221
 None
 0.94A 3kpdC-1cmxA:
0.0		 3kpdC-1cmxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TGV_B_BEZB160_0
(HEME-BINDING PROTEIN
HUTZ)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  27
GLY A  26
LEU A 106
GLU A 107
 None
 1.03A 3tgvB-1cmxA:
0.0		 3tgvB-1cmxA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V8V_A_SAMA801_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE L)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		5 / 12 ILE A  55
SER A  98
THR A 169
SER A 104
PRO A  51
 None
 1.18A 3v8vA-1cmxA:
undetectable		 3v8vA-1cmxA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I41_A_MIXA500_2
(SERINE/THREONINE-PRO
TEIN KINASE PIM-1)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 4 LEU A  39
LEU A 229
GLN A 204
GLU A 179
 None
 1.21A 4i41A-1cmxA:
undetectable		 4i41A-1cmxA:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YOA_A_017A100_1
(HIV-1 PROTEASE)		 1cmx PROTEIN (UBIQUITIN
YUH1-UBAL)
(Saccharomyces
cerevisiae) 		4 / 6 ASN A 101
ASP A  78
THR A 169
VAL A 171
 None
 1.08A 4yoaA-1cmxA:
undetectable		 4yoaA-1cmxA:
17.11