SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cn3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_A_DVAA8_0
(GRAMICIDIN A)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		3 / 4 VAL A 315
TRP A 120
TRP A 314
 None
 1.33A 1gmkA-1cn3A:
undetectable
1gmkB-1cn3A:
undetectable		 1gmkA-1cn3A:
4.64
1gmkB-1cn3A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GMK_D_DVAD8_0
(GRAMICIDIN A)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		3 / 3 TRP A  98
VAL A 190
TRP A 227
 None
 1.19A 1gmkC-1cn3A:
undetectable
1gmkD-1cn3A:
undetectable		 1gmkC-1cn3A:
4.64
1gmkD-1cn3A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1I9G_A_SAMA301_0
(HYPOTHETICAL PROTEIN
RV2118C)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		5 / 12 ILE A 308
GLY A 169
ALA A 122
ASP A 217
LEU A 216
 None
 1.25A 1i9gA-1cn3A:
undetectable		 1i9gA-1cn3A:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DDW_A_PXLA1003_1
(PYRIDOXINE KINASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		4 / 8 VAL A 283
LEU A 172
PRO A 229
ASP A 284
 None
 0.89A 2ddwA-1cn3A:
undetectable		 2ddwA-1cn3A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_A_THRA401_0
(ASPARTOKINASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		4 / 8 GLY A 270
GLU A 121
ALA A 122
ASN A 236
 None
 0.78A 2dtjA-1cn3A:
undetectable
2dtjB-1cn3A:
undetectable		 2dtjA-1cn3A:
21.35
2dtjB-1cn3A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2O4N_A_TPVA300_2
(PROTEASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		4 / 8 LEU A 216
ALA A 166
GLY A 241
LEU A 174
 None
 0.59A 2o4nB-1cn3A:
0.0		 2o4nB-1cn3A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_A_4CHA191_0
(DEHALOPEROXIDASE A)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		4 / 6 PHE A 165
PHE A 240
THR A 127
VAL A 125
 None
 1.17A 3lb3A-1cn3A:
undetectable		 3lb3A-1cn3A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ZQ8_B_DVAB8_0
(VAL-GRAMICIDIN A)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		3 / 3 TRP A 299
VAL A 296
TRP A 288
 None
 1.08A 3zq8A-1cn3A:
undetectable
3zq8B-1cn3A:
undetectable		 3zq8A-1cn3A:
4.64
3zq8B-1cn3A:
4.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E7C_D_ACTD504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		3 / 3 GLY A 246
SER A 160
TRP A 288
 None
 0.90A 4e7cD-1cn3A:
0.0		 4e7cD-1cn3A:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_2
(GLUCOCORTICOID
RECEPTOR)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		3 / 3 MET A 100
MET A  57
TYR A 222
 None
 1.24A 4p6xI-1cn3A:
0.0		 4p6xI-1cn3A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_A_MTXA604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		5 / 12 VAL A 125
ALA A 122
LEU A 105
SER A 281
LEU A  53
 None
 1.18A 4q0dA-1cn3A:
undetectable		 4q0dA-1cn3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_B_MTXB604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		5 / 12 VAL A 125
ALA A 122
LEU A 105
SER A 281
LEU A  53
 None
 1.18A 4q0dB-1cn3A:
undetectable		 4q0dB-1cn3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q0D_E_MTXE604_1
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		5 / 12 VAL A 125
ALA A 122
LEU A 105
SER A 281
LEU A  53
 None
 1.18A 4q0dE-1cn3A:
undetectable		 4q0dE-1cn3A:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TL8_A_X2NA502_2
(PROTEIN CYP51)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		4 / 6 PRO A 271
LEU A 280
PHE A 165
LEU A 172
 None
 0.98A 5tl8A-1cn3A:
0.0		 5tl8A-1cn3A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UC1_B_486B801_1
(GLUCOCORTICOID
RECEPTOR)		 1cn3 COAT PROTEIN VP1
(Polyomavirus
sp.) 		3 / 3 TRP A 120
MET A 119
ASN A 109
 None
 1.45A 5uc1A-1cn3A:
undetectable		 5uc1A-1cn3A:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
7DFR_A_FOLA161_1
(DIHYDROFOLATE
REDUCTASE)		 1cn3 FRAGMENT OF COAT
PROTEIN VP2
(Mus
musculus
polyomavirus
1) 		3 / 3 ASP F  18
LEU F  21
ARG F  14
 None
 0.85A 7dfrA-1cn3F:
undetectable		 7dfrA-1cn3F:
14.95