SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cns'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 7 SER A 120
TYR A 123
ASN A 122
TYR A 125
 None
 1.01A 1dssG-1cnsA:
undetectable		 1dssG-1cnsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 8 SER A 120
TYR A 123
ASN A 122
TYR A 125
 None
 1.01A 1dssR-1cnsA:
undetectable		 1dssR-1cnsA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RBP_A_RTLA183_0
(PLASMA
RETINOL-BINDING
PROTEIN PRECURSOR)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 12 LEU A 226
ALA A  39
ALA A  38
VAL A   6
LEU A  61
 None
 1.32A 1rbpA-1cnsA:
undetectable		 1rbpA-1cnsA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C6N_B_LPRB705_2
(ANGIOTENSIN-CONVERTI
NG ENZYME, SOMATIC
ISOFORM)		 1cns CHITINASE
(Hordeum
vulgare) 		3 / 3 ALA A 154
THR A  64
PHE A  41
 None
 0.64A 2c6nB-1cnsA:
0.0		 2c6nB-1cnsA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F7F_A_NIOA601_1
(NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 6 PHE A 218
ARG A 215
GLY A  83
THR A  69
 None
 1.07A 2f7fA-1cnsA:
undetectable		 2f7fA-1cnsA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_A_X2NA1480_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 12 PHE A  60
MET A 155
ALA A  62
ALA A  40
ALA A  36
 None
 1.20A 2x2nA-1cnsA:
undetectable		 2x2nA-1cnsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 12 PHE A  60
MET A 155
ALA A  62
ALA A  40
ALA A  36
 None
 1.17A 2x2nB-1cnsA:
undetectable		 2x2nB-1cnsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X2N_B_X2NB1479_1
(LANOSTEROL
14-ALPHA-DEMETHYLASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 12 PHE A  60
MET A 155
PHE A  41
ALA A  62
ALA A  40
 None
 1.29A 2x2nB-1cnsA:
undetectable		 2x2nB-1cnsA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IA4_A_MTXA164_2
(DIHYDROFOLATE
REDUCTASE)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 4 ILE A 198
PHE A 157
ILE A 197
THR A  64
 None
 1.16A 3ia4A-1cnsA:
undetectable		 3ia4A-1cnsA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_B_CLMB221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 12 SER A  65
TYR A  84
VAL A   2
PHE A  44
PHE A  11
 None
 1.39A 3u9fB-1cnsA:
undetectable
3u9fC-1cnsA:
undetectable		 3u9fB-1cnsA:
19.92
3u9fC-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_C_CLMC221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 11 PHE A  11
SER A  65
TYR A  84
VAL A   2
PHE A  44
 None
 1.38A 3u9fA-1cnsA:
undetectable
3u9fC-1cnsA:
undetectable		 3u9fA-1cnsA:
19.92
3u9fC-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_L_CLML221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 12 PHE A  11
SER A  65
TYR A  84
VAL A   2
PHE A  44
 None
 1.38A 3u9fJ-1cnsA:
undetectable
3u9fL-1cnsA:
undetectable		 3u9fJ-1cnsA:
19.92
3u9fL-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_M_CLMM221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 10 SER A  65
TYR A  84
VAL A   2
PHE A  44
PHE A  11
 None
 1.36A 3u9fM-1cnsA:
undetectable
3u9fN-1cnsA:
undetectable		 3u9fM-1cnsA:
19.92
3u9fN-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_N_CLMN221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 11 SER A  65
TYR A  84
VAL A   2
PHE A  44
PHE A  11
 None
 1.44A 3u9fN-1cnsA:
undetectable
3u9fO-1cnsA:
undetectable		 3u9fN-1cnsA:
19.92
3u9fO-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U9F_O_CLMO221_0
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 11 PHE A  11
SER A  65
TYR A  84
VAL A   2
PHE A  44
 None
 1.39A 3u9fM-1cnsA:
undetectable
3u9fO-1cnsA:
undetectable		 3u9fM-1cnsA:
19.92
3u9fO-1cnsA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UY4_A_PAUA302_0
(PANTOTHENATE
SYNTHETASE)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 8 HIS A 169
VAL A 173
VAL A  52
GLN A 175
 None
 1.11A 3uy4A-1cnsA:
undetectable		 3uy4A-1cnsA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 8 GLY A 201
GLY A 200
HIS A 206
ASP A 209
 None
 0.74A 5f8yA-1cnsA:
undetectable		 5f8yA-1cnsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 1cns CHITINASE
(Hordeum
vulgare) 		4 / 8 GLY A 201
GLY A 200
HIS A 206
ASP A 209
 None
 0.75A 5f8yB-1cnsA:
undetectable		 5f8yB-1cnsA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IK1_A_CAMA503_0
(CAMPHOR
5-MONOOXYGENASE)		 1cns CHITINASE
(Hordeum
vulgare) 		5 / 7 GLY A  43
THR A  47
VAL A  52
ILE A 172
VAL A 173
 None
 1.48A 5ik1A-1cnsA:
1.8		 5ik1A-1cnsA:
19.56