SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cnz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 12 GLY A 352
VAL A  26
ILE A 299
ALA A 325
ILE A 326
 None
 0.95A 1bx4A-1cnzA:
4.0		 1bx4A-1cnzA:
24.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IOL_A_ESTA400_1
(ESTROGENIC 17-BETA
HYDROXYSTEROID
DEHYDROGENASE)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 11 SER A 312
TYR A 280
GLY A 276
HIS A 101
GLU A  66
 None
 1.44A 1iolA-1cnzA:
undetectable		 1iolA-1cnzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIK_A_ADNA799_1
(ADENOSINE KINASE)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 10 GLY A 352
VAL A  26
ALA A 329
ALA A 325
ILE A 326
 None
 0.98A 1likA-1cnzA:
undetectable		 1likA-1cnzA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OHR_A_1UNA201_1
(ASPARTYLPROTEASE)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		6 / 11 ALA A 287
ASP A 289
THR A 348
PRO A 298
VAL A  19
ILE A  15
 None
 1.29A 1ohrA-1cnzA:
undetectable		 1ohrA-1cnzA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2UXP_A_CLMA1211_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR TTGR)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 8 ALA A 315
LEU A 309
LEU A 305
VAL A  26
ILE A 355
 None
 1.26A 2uxpA-1cnzA:
0.0		 2uxpA-1cnzA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W03_A_ADNA1588_1
(ACSD)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 10 HIS A  42
PRO A  11
ILE A  38
THR A  40
ARG A  31
 None
 1.17A 2w03A-1cnzA:
0.0		 2w03A-1cnzA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 11 LEU A 135
ILE A 134
SER A 254
VAL A 219
LEU A 221
 None
 1.40A 3a9eB-1cnzA:
undetectable		 3a9eB-1cnzA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_A_DR7A100_2
(PROTEASE)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 9 ALA A 287
ASP A 289
PRO A 298
VAL A  19
ILE A  15
 None
 1.20A 3em4B-1cnzA:
undetectable		 3em4B-1cnzA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_A_ICFA1_1
(INTEGRIN ALPHA-L)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 9 ILE A  38
TYR A   5
ILE A   7
LEU A 308
LEU A 309
 None
 0.68A 3f78A-1cnzA:
2.6		 3f78A-1cnzA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F78_B_ICFB2_1
(INTEGRIN ALPHA-L)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 9 ILE A  38
TYR A   5
ILE A   7
LEU A 308
LEU A 309
 None
 0.68A 3f78B-1cnzA:
2.4		 3f78B-1cnzA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GWX_A_EPAA1_2
(PROTEIN (PEROXISOME
PROLIFERATOR
ACTIVATED RECEPTOR
(PPAR-DELTA)))		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 12 THR A  39
THR A  40
HIS A  42
ILE A  71
LEU A  24
 None
 1.29A 3gwxA-1cnzA:
undetectable		 3gwxA-1cnzA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OXX_A_DR7A100_2
(HIV-1 PROTEASE)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 11 ALA A 287
ASP A 289
PRO A 298
VAL A  19
ILE A  15
 None
 1.17A 3oxxB-1cnzA:
undetectable		 3oxxB-1cnzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJW_A_SRYA2001_2
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		4 / 6 GLU A 323
ILE A 326
ASN A 327
GLU A 118
 None
 0.74A 4ejwB-1cnzA:
0.0		 4ejwB-1cnzA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_A_SAMA401_0
(METHYLTRANSFERASE
NSUN4)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 12 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9A-1cnzA:
undetectable		 4fp9A-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_C_SAMC401_0
(METHYLTRANSFERASE
NSUN4)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 12 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9C-1cnzA:
undetectable		 4fp9C-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_0
(METHYLTRANSFERASE
NSUN4)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 12 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9D-1cnzA:
undetectable		 4fp9D-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_F_SAMF401_0
(METHYLTRANSFERASE
NSUN4)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 12 PRO A 282
GLY A 284
GLY A 285
LEU A 108
LEU A 140
 None
 1.02A 4fp9F-1cnzA:
undetectable		 4fp9F-1cnzA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_2
(CYP51 VARIANT1)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		3 / 3 PRO A  56
ILE A  15
SER A  88
 None
 0.81A 5fsaA-1cnzA:
0.0		 5fsaA-1cnzA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KMD_C_6UBC1304_1
(ION TRANSPORT
PROTEIN)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		4 / 5 TYR A 145
ILE A 144
LEU A 253
GLY A 250
 SO4  A 902 (-4.5A)
None
None
None
 0.79A 5kmdC-1cnzA:
0.0
5kmdD-1cnzA:
undetectable		 5kmdC-1cnzA:
19.89
5kmdD-1cnzA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_1
(PROTEASE E35D-SQV)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		6 / 12 ALA A 287
ASP A 289
THR A 348
PRO A 298
VAL A  19
ILE A  15
 None
 1.33A 5kqxA-1cnzA:
undetectable		 5kqxA-1cnzA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L94_A_TESA502_1
(CYTOCHROME P450)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		5 / 8 VAL A 137
ILE A 175
ALA A 176
VAL A 190
VAL A 242
 None
 1.06A 5l94A-1cnzA:
0.0		 5l94A-1cnzA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B5V_B_ECLB1001_1
(TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 5)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		4 / 7 ALA A   8
PHE A 102
LEU A  98
ILE A  48
 None
 0.89A 6b5vA-1cnzA:
0.0
6b5vB-1cnzA:
0.0		 6b5vA-1cnzA:
13.02
6b5vB-1cnzA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJ2_B_AB1B201_0
(HIV-1 PROTEASE)		 1cnz PROTEIN
(3-ISOPROPYLMALATE
DEHYDROGENASE)
(Salmonella
enterica) 		6 / 10 ALA A 287
ASP A 289
ILE A 295
PRO A 298
VAL A  19
ILE A  15
 None
 1.35A 6dj2A-1cnzA:
undetectable		 6dj2A-1cnzA:
11.90