SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1coj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		5 / 10 GLU A 205
ALA A 200
LYS A 103
LEU A 140
GLU A 106
 None
 1.27A 1ie4A-1cojA:
0.0
1ie4C-1cojA:
0.0		 1ie4A-1cojA:
19.63
1ie4C-1cojA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_A_T44A128_1
(TRANSTHYRETIN)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		5 / 10 LYS A 103
LEU A 140
GLU A 106
GLU A 205
ALA A 200
 None
 1.22A 1ie4A-1cojA:
0.0
1ie4C-1cojA:
0.0		 1ie4A-1cojA:
19.63
1ie4C-1cojA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IE4_B_T44B328_1
(TRANSTHYRETIN)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		5 / 8 GLU A 205
ALA A 200
LYS A 103
GLU A 106
ALA A  99
 None
 1.33A 1ie4B-1cojA:
undetectable
1ie4D-1cojA:
0.0		 1ie4B-1cojA:
19.63
1ie4D-1cojA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		5 / 12 ILE A  19
VAL A 193
LEU A  88
LEU A 118
ILE A 162
 None
 1.28A 1kqwA-1cojA:
undetectable		 1kqwA-1cojA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FRQ_B_ERYB195_1
(REPRESSOR PROTEIN
MPHR(A))		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		4 / 7 ASN A  74
TYR A  35
ASN A 152
ALA A 147
 None
 1.30A 3frqB-1cojA:
0.0		 3frqB-1cojA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1002_1
(HEMOLYTIC LECTIN
CEL-III)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		3 / 3 ASP A 112
GLU A 105
GLY A 109
 None
 0.65A 3w9tA-1cojA:
undetectable		 3w9tA-1cojA:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R88_A_1LDA501_0
(CYTOSINE DEAMINASE)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		5 / 12 HIS A  81
PHE A  85
ILE A  24
HIS A  27
HIS A 167
 FE  A 213 (-3.4A)
None
None
FE  A 213 (-3.3A)
FE  A 213 (-3.3A)
 1.35A 4r88A-1cojA:
undetectable		 4r88A-1cojA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		5 / 10 PRO A  13
ILE A 181
PHE A 184
ALA A 122
VAL A 161
 None
 1.37A 5m0oA-1cojA:
0.0		 5m0oA-1cojA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7U_A_FVTA501_0
(PEPTIDE ABC
TRANSPORTER PERMEASE)		 1coj PROTEIN (SUPEROXIDE
DISMUTASE)
(Aquifex
pyrophilus) 		4 / 6 VAL A 150
ASN A 149
ASN A  74
GLU A  70
 None
 1.19A 6h7uA-1cojA:
undetectable		 6h7uA-1cojA:
17.70