SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1coz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PG2_A_ADNA552_1
(METHIONYL-TRNA
SYNTHETASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 11 HIS A  14
GLY A  16
HIS A  17
GLY A  92
ASP A  94
 CTP  A 130 (-4.2A)
CTP  A 130 ( 4.1A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.3A)
CTP  A 130 (-3.9A)
 0.72A 1pg2A-1cozA:
5.4		 1pg2A-1cozA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_A_ADNA433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 12 LEU A  21
THR A   6
LEU A 111
GLY A  92
PHE A  10
 None
None
None
CTP  A 130 (-3.3A)
CTP  A 130 (-4.3A)
 1.14A 1xwfA-1cozA:
2.4		 1xwfA-1cozA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XWF_B_ADNB433_1
(ADENOSYLHOMOCYSTEINA
SE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 12 LEU A  21
THR A   6
LEU A 111
GLY A  92
PHE A  10
 None
None
None
CTP  A 130 (-3.3A)
CTP  A 130 (-4.3A)
 1.14A 1xwfB-1cozA:
3.3		 1xwfB-1cozA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1291_1
(FICOLIN-2)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 4 ASP A  94
LEU A 111
GLY A  92
ARG A  23
 CTP  A 130 (-3.9A)
None
CTP  A 130 (-3.3A)
None
 1.44A 2j2pD-1cozA:
0.0
2j2pE-1cozA:
0.0		 2j2pD-1cozA:
20.18
2j2pE-1cozA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1499_1
(CYTOCHROME P450 3A4)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 7 PHE A  10
PHE A  89
ILE A  81
GLY A   8
 CTP  A 130 (-4.3A)
None
None
CTP  A 130 ( 3.8A)
 0.86A 2v0mB-1cozA:
0.0		 2v0mB-1cozA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2X1L_A_ADNA601_1
(METHIONYL-TRNA
SYNTHETASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 11 HIS A  14
GLY A  16
HIS A  17
GLY A  92
ASP A  94
 CTP  A 130 (-4.2A)
CTP  A 130 ( 4.1A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.3A)
CTP  A 130 (-3.9A)
 0.94A 2x1lA-1cozA:
6.1		 2x1lA-1cozA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P4W_C_DSFC320_1
(GLR4197 PROTEIN)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 8 TYR A  52
ILE A  35
VAL A  68
ILE A  58
 None
 0.83A 3p4wC-1cozA:
undetectable		 3p4wC-1cozA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZR_E_PFLE409_1
(PROTON-GATED ION
CHANNEL)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 8 TYR A  52
ILE A  35
VAL A  68
ILE A  58
 None
 0.85A 5mzrE-1cozA:
undetectable		 5mzrE-1cozA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_H_PCFH604_0
(CYTOCHROME B-C1
COMPLEX SUBUNIT 8
CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 8 GLY A  16
HIS A  17
GLY A  92
ALA A  24
 CTP  A 130 ( 4.1A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.3A)
None
 0.79A 6hu9H-1cozA:
undetectable
6hu9e-1cozA:
undetectable		 6hu9H-1cozA:
21.58
6hu9e-1cozA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JMJ_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 5 GLY A   8
THR A   9
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.75A 6jmjA-1cozA:
12.9		 6jmjA-1cozA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JNH_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		5 / 7 GLY A   8
THR A   9
PHE A  10
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.81A 6jnhA-1cozA:
13.0		 6jnhA-1cozA:
26.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6JOG_A_ASCA201_0
(PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE)		 1coz PROTEIN
(GLYCEROL-3-PHOSPHAT
E
CYTIDYLYLTRANSFERASE
)
(Bacillus
subtilis) 		4 / 6 GLY A   8
THR A   9
HIS A  17
SER A 118
 CTP  A 130 ( 3.8A)
CTP  A 130 (-4.3A)
CTP  A 130 (-3.7A)
CTP  A 130 (-3.9A)
 0.81A 6jogA-1cozA:
12.9		 6jogA-1cozA:
26.47