SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cr5'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1BX4_A_ADNA355_1
(PROTEIN (ADENOSINE
KINASE))		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		5 / 12 GLY A 196
GLN A 156
ILE A 171
GLY A 115
ILE A 117
 None
 0.91A 1bx4A-1cr5A:
undetectable		 1bx4A-1cr5A:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		3 / 3 PRO A  35
ASN A  33
ARG A  86
 NEN  A 601 (-3.8A)
None
None
 0.91A 2qeuB-1cr5A:
undetectable		 2qeuB-1cr5A:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1356_1
(PROSTAGLANDIN
REDUCTASE 2)		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 117
PHE A 206
LEU A 158
LEU A 169
 None
 0.72A 2w98B-1cr5A:
undetectable		 2w98B-1cr5A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AC9_C_DXCC1475_0
(MJ0495-LIKE PROTEIN)		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		4 / 8 ILE A 119
ASP A 118
ILE A 117
GLY A 196
 None
 0.81A 4ac9C-1cr5A:
2.6		 4ac9C-1cr5A:
16.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_A_P06A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  66
ILE A  60
ASP A  51
 None
 0.75A 5cswA-1cr5A:
0.0		 5cswA-1cr5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CSW_B_P06B801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  66
ILE A  60
ASP A  51
 None
 0.73A 5cswB-1cr5A:
0.0		 5cswB-1cr5A:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LG3_G_Z80G401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 1cr5 SEC18P (RESIDUES 22
- 210)
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 119
ILE A 121
PHE A 167
GLU A 138
ASP A 135
 None
 1.27A 5lg3G-1cr5A:
0.0		 5lg3G-1cr5A:
22.44