SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1crk'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_B_MTXB301_1
(PTERIDINE REDUCTASE)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 11 PRO A  31
ASP A  49
TYR A  15
TYR A  34
HIS A  21
 None
 1.48A 1e7wB-1crkA:
undetectable		 1e7wB-1crkA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FSL_A_NIOA145_1
(LEGHEMOGLOBIN A)		 1crk CREATINE KINASE
(Gallus
gallus) 		4 / 8 PHE A 266
ILE A 259
HIS A 229
VAL A 255
 None
 0.91A 1fslA-1crkA:
0.0		 1fslA-1crkA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LWC_A_NVPA999_1
(HIV-1 REVERSE
TRANSCRIPTASE)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 11 LEU A 355
VAL A 290
TYR A 329
GLY A 289
LEU A 307
 None
 1.40A 1lwcA-1crkA:
2.9		 1lwcA-1crkA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 12 MET A  25
LEU A 196
CYH A  51
ILE A  83
PHE A  84
 None
 1.39A 1p93B-1crkA:
undetectable		 1p93B-1crkA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QHY_A_CLMA888_0
(CHLORAMPHENICOL
PHOSPHOTRANSFERASE)		 1crk CREATINE KINASE
(Gallus
gallus) 		4 / 6 PRO A 139
MET A 202
GLU A 226
GLU A 227
 None
 1.33A 1qhyA-1crkA:
undetectable		 1qhyA-1crkA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QW6_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 ARG A 125
VAL A 222
TRP A 223
 PO4  A 401 (-2.7A)
None
None
 1.04A 1qw6A-1crkA:
undetectable		 1qw6A-1crkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QWC_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 ARG A 125
VAL A 222
TRP A 223
 PO4  A 401 (-2.7A)
None
None
 1.03A 1qwcA-1crkA:
0.0		 1qwcA-1crkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1VAG_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 ARG A 125
VAL A 222
TRP A 223
 PO4  A 401 (-2.7A)
None
None
 1.02A 1vagA-1crkA:
0.0		 1vagA-1crkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZVI_A_H4BA901_1
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 ARG A 125
VAL A 222
TRP A 223
 PO4  A 401 (-2.7A)
None
None
 1.00A 1zviA-1crkA:
0.0		 1zviA-1crkA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_F_SAMF301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 LYS A 380
ASP A 107
CYH A 249
 None
 1.25A 2br4F-1crkA:
undetectable		 2br4F-1crkA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_A_SAMA201_0
(UPF0066 PROTEIN
AF_0241)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 12 GLN A  53
TYR A  46
GLY A  72
LEU A 137
SER A  47
 None
 1.06A 2nv4A-1crkA:
0.0		 2nv4A-1crkA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NV4_B_SAMB202_0
(UPF0066 PROTEIN
AF_0241)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 12 GLN A  53
TYR A  46
GLY A  72
LEU A 137
SER A  47
 None
 1.02A 2nv4B-1crkA:
0.0		 2nv4B-1crkA:
17.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3B6R_B_CRNB603_1
(CREATINE KINASE
B-TYPE)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 6 THR A  66
VAL A  67
GLU A 227
CYH A 278
SER A 280
 None
 0.80A 3b6rB-1crkA:
49.8		 3b6rB-1crkA:
63.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B9M_A_SALA1200_1
(SERUM ALBUMIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		4 / 5 ILE A  88
HIS A  92
TYR A  77
GLY A 283
 None
 1.20A 3b9mA-1crkA:
0.0		 3b9mA-1crkA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_2
(CYTOCHROME P450 2R1)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 MET A 241
VAL A 352
GLU A 118
 None
 0.86A 3c6gA-1crkA:
0.0		 3c6gA-1crkA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gB-1crkA:
undetectable		 3j6gB-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_D_TA1D502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gD-1crkA:
undetectable		 3j6gD-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_F_TA1F502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gF-1crkA:
undetectable		 3j6gF-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_H_TA1H502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gH-1crkA:
0.0		 3j6gH-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_J_TA1J502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gJ-1crkA:
undetectable		 3j6gJ-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_L_TA1L502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gL-1crkA:
undetectable		 3j6gL-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_N_TA1N502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gN-1crkA:
undetectable		 3j6gN-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_P_TA1P502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gP-1crkA:
undetectable		 3j6gP-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3J6G_R_TA1R502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 ASP A 163
LEU A 221
THR A 230
ARG A 250
LEU A 252
 None
 1.34A 3j6gR-1crkA:
undetectable		 3j6gR-1crkA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP1_A_NVPA701_1
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 10 LEU A 355
VAL A 290
TYR A 329
GLY A 289
LEU A 307
 None
 1.31A 3lp1A-1crkA:
2.6		 3lp1A-1crkA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_D_VIVD301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 12 VAL A 244
SER A 124
ILE A 111
ILE A 349
VAL A 352
 None
 1.31A 3w67D-1crkA:
undetectable		 3w67D-1crkA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4V1F_B_BQ1B1087_0
(F0F1 ATP SYNTHASE
SUBUNIT C)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 8 ALA A  32
GLU A  82
ALA A  81
PHE A  80
LEU A  48
 None
 1.48A 4v1fA-1crkA:
0.0
4v1fB-1crkA:
0.0		 4v1fA-1crkA:
12.81
4v1fB-1crkA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_0
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 12 GLN A 313
ILE A 331
VAL A 290
GLY A 351
LEU A 286
 PO4  A 400 ( 4.8A)
None
None
None
None
 1.20A 5ergB-1crkA:
undetectable		 5ergB-1crkA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FVO_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 ARG A 125
VAL A 222
TRP A 223
 PO4  A 401 (-2.7A)
None
None
 1.02A 5fvoA-1crkA:
0.0		 5fvoA-1crkA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5SYF_B_TA1B502_1
(TUBULIN BETA CHAIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		5 / 12 VAL A 348
LEU A 106
ALA A 288
SER A 332
ARG A 311
 None
 1.35A 5syfB-1crkA:
undetectable		 5syfB-1crkA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6J_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 MET A 202
ASP A 228
ARG A  91
 None
 0.99A 5z6jA-1crkA:
undetectable		 5z6jA-1crkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z6K_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 MET A 202
ASP A 228
ARG A  91
 None
 1.03A 5z6kA-1crkA:
0.0		 5z6kA-1crkA:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1crk CREATINE KINASE
(Gallus
gallus) 		3 / 3 ARG A  98
ARG A 271
ASP A  85
 None
 0.93A 6d8pA-1crkA:
0.4		 6d8pA-1crkA:
19.27