SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1crl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 GLU A 208
SER A 209
PHE A 344
HIS A 449
 None
 1.00A 1ax9A-1crlA:
41.0		 1ax9A-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 8 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 0.64A 1ax9A-1crlA:
41.0		 1ax9A-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1AX9_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 GLY A 124
SER A 209
PHE A 345
HIS A 449
 None
 0.84A 1ax9A-1crlA:
41.0		 1ax9A-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 12 GLY A 122
GLY A 123
GLY A 124
SER A 209
PHE A 296
HIS A 449
 None
 1.34A 1dx6A-1crlA:
40.7		 1dx6A-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 12 GLY A 122
GLY A 123
GLY A 124
SER A 209
PHE A 345
HIS A 449
 None
 0.49A 1dx6A-1crlA:
40.7		 1dx6A-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 12 GLY A 122
GLY A 124
SER A 209
PHE A 344
PHE A 345
HIS A 449
 None
 0.73A 1dx6A-1crlA:
40.7		 1dx6A-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1DX6_A_GNTA602_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
SER A 209
PHE A 344
PHE A 345
HIS A 449
 None
 0.77A 1dx6A-1crlA:
40.7		 1dx6A-1crlA:
32.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E71_M_ASCM995_0
(MYROSINASE MA1)		 1crl LIPASE
(Diutina
rugosa) 		4 / 7 ILE A 453
TYR A 467
PHE A 471
PHE A 434
 None
 1.05A 1e71M-1crlA:
1.1		 1e71M-1crlA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E72_M_ASCM995_0
(MYROSINASE MA1)		 1crl LIPASE
(Diutina
rugosa) 		4 / 7 ILE A 453
TYR A 467
PHE A 471
PHE A 434
 None
 1.03A 1e72M-1crlA:
0.0		 1e72M-1crlA:
21.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_A_DMEA998_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
GLU A 208
SER A 209
PHE A 296
HIS A 449
 None
 1.41A 1maaA-1crlA:
37.0		 1maaA-1crlA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 GLY A 123
GLU A 208
SER A 209
HIS A 449
 None
 0.34A 1maaD-1crlA:
37.0		 1maaD-1crlA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MAA_D_DMED999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 GLY A 124
GLU A 208
SER A 209
HIS A 449
 None
 0.88A 1maaD-1crlA:
37.0		 1maaD-1crlA:
32.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
 None
 0.95A 1mx1D-1crlA:
39.8		 1mx1D-1crlA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_D_THAD4_1
(LIVER
CARBOXYLESTERASE I)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
GLY A 124
SER A 209
PHE A 415
HIS A 449
 None
 0.66A 1mx1D-1crlA:
39.8		 1mx1D-1crlA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
VAL A 127
SER A 209
PHE A 415
HIS A 449
 None
 0.47A 1mx1E-1crlA:
40.0		 1mx1E-1crlA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1MX1_F_THAF6_1
(LIVER
CARBOXYLESTERASE I)		 1crl LIPASE
(Diutina
rugosa) 		6 / 12 GLY A 123
GLY A 124
SER A 209
LEU A 304
PHE A 415
HIS A 449
 None
 0.80A 1mx1F-1crlA:
39.5		 1mx1F-1crlA:
30.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1QTI_A_GNTA600_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		8 / 12 GLY A 122
GLY A 123
GLY A 124
GLU A 208
SER A 209
PHE A 345
PHE A 296
HIS A 449
 None
 1.29A 1qtiA-1crlA:
40.9		 1qtiA-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W6R_A_GNTA1536_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		7 / 12 GLY A 122
GLY A 123
GLY A 124
SER A 209
PHE A 345
PHE A 296
HIS A 449
 None
 1.30A 1w6rA-1crlA:
40.7		 1w6rA-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 11 GLY A 123
GLU A 208
SER A 209
PHE A 344
PHE A 345
HIS A 449
 None
 0.89A 1w76A-1crlA:
41.0		 1w76A-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_A_GNTA1538_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 11 GLY A 124
GLU A 208
SER A 209
PHE A 344
PHE A 345
HIS A 449
 None
 0.52A 1w76A-1crlA:
41.0		 1w76A-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 GLY A 123
GLY A 124
SER A 209
PHE A 345
HIS A 449
 None
 1.08A 1w76B-1crlA:
41.0		 1w76B-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1W76_B_GNTB1538_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 GLY A 124
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 1.00A 1w76B-1crlA:
41.0		 1w76B-1crlA:
32.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 122
GLY A 123
SER A 209
LEU A 297
HIS A 449
 None
 1.01A 1ya4A-1crlA:
40.0		 1ya4A-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_A_CTXA1_1
(CES1 PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
 None
 0.92A 1ya4A-1crlA:
40.0		 1ya4A-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YA4_C_CTXC3_1
(CES1 PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
GLY A 124
SER A 209
LEU A 304
HIS A 449
 None
 0.93A 1ya4C-1crlA:
39.4		 1ya4C-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		6 / 8 GLY A 122
GLY A 123
GLY A 124
SER A 209
ALA A 210
HIS A 449
 None
 0.47A 1yajC-1crlA:
38.9		 1yajC-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 8 GLY A 123
GLY A 124
SER A 209
ALA A 210
HIS A 449
 None
 0.73A 1yajC-1crlA:
38.9		 1yajC-1crlA:
30.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1YAJ_C_BEZC5013_0
(CES1 PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		6 / 8 GLY A 211
GLY A 122
GLY A 123
SER A 209
ALA A 210
HIS A 449
 None
 1.20A 1yajC-1crlA:
38.9		 1yajC-1crlA:
30.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YVP_A_ACTA2001_0
(60-KDA SS-A/RO
RIBONUCLEOPROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		4 / 5 SER A 160
SER A 159
THR A 290
ASN A 291
 None
 1.42A 1yvpA-1crlA:
undetectable		 1yvpA-1crlA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A15_A_NCAA1001_0
(HYPOTHETICAL PROTEIN
RV0760C)		 1crl LIPASE
(Diutina
rugosa) 		5 / 11 SER A 365
VAL A 534
LEU A 304
LEU A 410
TYR A 361
 None
 1.19A 2a15A-1crlA:
0.0		 2a15A-1crlA:
14.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		7 / 9 GLY A 123
GLY A 124
SER A 209
ALA A 210
PHE A 345
PHE A 296
HIS A 449
 None
 1.30A 2aceA-1crlA:
41.1		 2aceA-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACE_A_ACHA998_0
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 9 GLY A 124
SER A 209
ALA A 210
PHE A 344
HIS A 449
 None
 0.75A 2aceA-1crlA:
41.1		 2aceA-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 7 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 0.66A 2ackA-1crlA:
40.9		 2ackA-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ACK_A_EDRA999_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		4 / 7 GLY A 124
SER A 209
PHE A 345
HIS A 449
 None
 0.90A 2ackA-1crlA:
40.9		 2ackA-1crlA:
32.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 8 GLY A 123
GLY A 124
ALA A 210
PHE A 345
PHE A 296
HIS A 449
 None
 1.45A 2ha4A-1crlA:
39.8		 2ha4A-1crlA:
32.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2HA4_A_ACTA544_0
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 8 GLY A 123
GLY A 124
ALA A 210
PHE A 415
HIS A 449
 None
 1.48A 2ha4A-1crlA:
39.8		 2ha4A-1crlA:
32.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 ILE A 374
ALA A 358
TYR A 381
LEU A 377
LEU A 302
 None
 1.32A 2rctA-1crlA:
0.0		 2rctA-1crlA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A3Y_A_OBNA6000_1
(NA, K-ATPASE ALPHA
SUBUNIT)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 GLY A 342
PHE A 345
PHE A 296
LEU A 297
THR A 347
 None
 1.19A 3a3yA-1crlA:
undetectable		 3a3yA-1crlA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 1crl LIPASE
(Diutina
rugosa) 		5 / 11 ALA A 475
LEU A 478
ILE A 331
PRO A 332
GLY A 237
 None
 1.22A 3bpxA-1crlA:
0.0
3bpxB-1crlA:
0.0		 3bpxA-1crlA:
13.20
3bpxB-1crlA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GY3_A_PNTA246_0
(CATIONIC TRYPSIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 11 GLN A 456
SER A 214
TRP A 119
GLY A 207
GLY A 211
 None
 1.11A 3gy3A-1crlA:
undetectable		 3gy3A-1crlA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HAV_A_SRYA403_1
(AMINOGLYCOSIDE
PHOSPHOTRANSFERASE)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 SER A 433
ASP A 515
ASP A 412
TYR A 320
 None
 1.21A 3havA-1crlA:
0.5		 3havA-1crlA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_E_TFPE201_1
(PROTEIN S100-A4)		 1crl LIPASE
(Diutina
rugosa) 		4 / 7 GLY A 242
PHE A 415
PHE A 296
PHE A 345
 None
 0.89A 3ko0D-1crlA:
2.7
3ko0E-1crlA:
2.2		 3ko0D-1crlA:
10.30
3ko0E-1crlA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_O_TFPO201_1
(PROTEIN S100-A4)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 PHE A 296
PHE A 345
GLY A 242
PHE A 415
 None
 0.99A 3ko0O-1crlA:
2.6
3ko0Q-1crlA:
1.7		 3ko0O-1crlA:
10.30
3ko0Q-1crlA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LP9_D_SPMD230_1
(LS-24)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 GLU A  66
GLU A  71
ASN A  72
 None
 0.77A 3lp9B-1crlA:
undetectable
3lp9D-1crlA:
undetectable		 3lp9B-1crlA:
17.99
3lp9D-1crlA:
17.99
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 7 GLY A 122
GLY A 123
SER A 209
PHE A 415
HIS A 449
 None
 1.41A 3o9mA-1crlA:
40.4		 3o9mA-1crlA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		6 / 7 GLY A 123
GLY A 124
SER A 209
LEU A 302
PHE A 415
HIS A 449
 None
 0.71A 3o9mA-1crlA:
40.4		 3o9mA-1crlA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_A_BEZA999_0
(CHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 7 GLY A 124
SER A 209
LEU A 302
PHE A 415
HIS A 449
 None
 1.02A 3o9mA-1crlA:
40.4		 3o9mA-1crlA:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3O9M_B_BEZB999_0
(CHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 6 GLY A 123
GLY A 124
SER A 209
LEU A 302
HIS A 449
 None
 0.78A 3o9mB-1crlA:
40.4		 3o9mB-1crlA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_A_CYZA266_2
(GLUTAMATE RECEPTOR 2)		 1crl LIPASE
(Diutina
rugosa) 		4 / 5 ILE A  26
PRO A  27
SER A  55
GLY A  25
 None
 1.04A 3tkdB-1crlA:
undetectable		 3tkdB-1crlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TKD_B_CYZB267_1
(GLUTAMATE RECEPTOR 2)		 1crl LIPASE
(Diutina
rugosa) 		4 / 5 ILE A  26
PRO A  27
SER A  55
GLY A  25
 None
 1.04A 3tkdA-1crlA:
undetectable		 3tkdA-1crlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TM4_B_SAMB401_0
(TRNA (GUANINE
N2-)-METHYLTRANSFERA
SE TRM14)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 ALA A 175
LEU A 164
GLY A 178
ALA A 210
PRO A 308
 None
 1.14A 3tm4B-1crlA:
undetectable		 3tm4B-1crlA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W67_B_VIVB301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 LEU A 377
VAL A 534
ILE A 406
VAL A 409
LEU A 410
 None
 1.04A 3w67B-1crlA:
1.3		 3w67B-1crlA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4AZV_A_SAMA1474_1
(WBDD)		 1crl LIPASE
(Diutina
rugosa) 		4 / 6 TYR A 467
GLN A 240
ASP A 457
GLN A 137
 None
 1.31A 4azvA-1crlA:
1.9		 4azvA-1crlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_F_ACTF402_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 PHE A 434
ASP A 515
ARG A 419
 None
 0.90A 4eahF-1crlA:
0.0		 4eahF-1crlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAH_G_ACTG401_0
(ACTIN, ALPHA
SKELETAL MUSCLE)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 PHE A 434
ASP A 515
ARG A 419
 None
 0.89A 4eahG-1crlA:
0.0		 4eahG-1crlA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB4_D_D16D402_1
(THYMIDYLATE SYNTHASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 PHE A 344
ASP A 412
GLY A 411
PHE A 345
LYS A 404
 None
 1.30A 4eb4D-1crlA:
0.0		 4eb4D-1crlA:
19.81
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_A_GNTA604_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		7 / 12 GLY A 122
GLY A 123
GLY A 124
SER A 209
PHE A 345
PHE A 296
HIS A 449
 None
 1.30A 4ey6A-1crlA:
40.0		 4ey6A-1crlA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		8 / 12 GLY A 122
GLY A 123
GLY A 124
GLU A 208
SER A 209
PHE A 345
PHE A 296
HIS A 449
 None
 1.28A 4ey6B-1crlA:
37.7		 4ey6B-1crlA:
31.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4EY6_B_GNTB605_1
(ACETYLCHOLINESTERASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 12 GLY A 123
GLU A 208
SER A 209
PHE A 345
HIS A 449
 None
 0.83A 4ey6B-1crlA:
37.7		 4ey6B-1crlA:
31.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 HIS A 368
GLY A 252
ILE A 253
 None
 0.61A 4k50A-1crlA:
0.0		 4k50A-1crlA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 HIS A 368
GLY A 252
ILE A 253
 None
 0.60A 4k50I-1crlA:
0.0		 4k50I-1crlA:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8F_B_BRLB501_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1crl LIPASE
(Diutina
rugosa) 		4 / 6 ILE A 334
GLY A 336
ILE A 453
ILE A 466
 None
 0.70A 4o8fB-1crlA:
0.0		 4o8fB-1crlA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X30_A_T44A401_1
(THYROXINE-BINDING
GLOBULIN)		 1crl LIPASE
(Diutina
rugosa) 		5 / 9 ALA A 289
LEU A 275
LEU A 262
LEU A 278
ARG A 279
 None
 1.49A 4x30A-1crlA:
0.0		 4x30A-1crlA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_1
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 ASP A 288
GLU A  71
SER A  93
 None
 0.86A 5bw4B-1crlA:
2.0		 5bw4B-1crlA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 SER A 209
ALA A 210
HIS A 449
LEU A 302
 None
 1.15A 5dzkd-1crlA:
0.3
5dzkr-1crlA:
undetectable		 5dzkd-1crlA:
17.18
5dzkr-1crlA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 1crl LIPASE
(Diutina
rugosa) 		4 / 8 SER A 209
ALA A 210
HIS A 449
LEU A 302
 None
 1.13A 5dzkF-1crlA:
0.3
5dzkT-1crlA:
undetectable		 5dzkF-1crlA:
17.18
5dzkT-1crlA:
0.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 THR A 354
ASP A 355
ALA A 356
 None
 0.09A 5g5gB-1crlA:
0.0		 5g5gB-1crlA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I9Y_A_1N1A1001_2
(EPHRIN TYPE-A
RECEPTOR 2)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 ILE A 466
ILE A 238
MET A 503
 None
 0.67A 5i9yA-1crlA:
undetectable		 5i9yA-1crlA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 ASP A 412
PHE A 517
ARG A 419
 None
 0.89A 5yw0A-1crlA:
0.0		 5yw0A-1crlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1crl LIPASE
(Diutina
rugosa) 		3 / 3 ASP A 412
PHE A 517
ARG A 420
 None
 1.10A 5yw0A-1crlA:
0.0		 5yw0A-1crlA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BOC_A_EU7A102_0
(MATRIX PROTEIN 2)		 1crl LIPASE
(Diutina
rugosa) 		4 / 6 ALA A 369
SER A 531
ALA A 372
SER A 370
 None
 1.05A 6bocA-1crlA:
undetectable
6bocB-1crlA:
undetectable
6bocC-1crlA:
undetectable
6bocD-1crlA:
undetectable		 6bocA-1crlA:
4.58
6bocB-1crlA:
4.58
6bocC-1crlA:
4.58
6bocD-1crlA:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_A_BEZA701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 11 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.94A 6qgbA-1crlA:
9.7		 6qgbA-1crlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_B_BEZB802_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.93A 6qgbB-1crlA:
10.3		 6qgbB-1crlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_C_BEZC701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 9 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.94A 6qgbC-1crlA:
10.3		 6qgbC-1crlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_D_BEZD701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.93A 6qgbD-1crlA:
2.5		 6qgbD-1crlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_E_BEZE701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 11 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.93A 6qgbE-1crlA:
10.7		 6qgbE-1crlA:
24.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6QGB_F_BEZF701_0
(MONO(2-HYDROXYETHYL)
TEREPHTHALATE
HYDROLASE)		 1crl LIPASE
(Diutina
rugosa) 		5 / 10 GLY A 124
SER A 209
SER A 301
PHE A 415
HIS A 449
 None
 0.91A 6qgbF-1crlA:
10.4		 6qgbF-1crlA:
24.49