SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1crz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 6 ARG A  52
ASP A  40
ASP A 165
ASN A 170
 None
 1.06A 1rjdA-1crzA:
undetectable		 1rjdA-1crzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 6 ARG A  52
ASP A  40
ASP A 165
ASN A 170
 None
 1.04A 1rjdB-1crzA:
undetectable		 1rjdB-1crzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 6 ARG A  52
ASP A  40
ASP A 165
ASN A 170
 None
 1.03A 1rjdC-1crzA:
undetectable		 1rjdC-1crzA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZLQ_A_ACTA1507_0
(NICKEL-BINDING
PERIPLASMIC PROTEIN)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 GLN A 208
HIS A 175
ARG A 176
 None
 0.75A 1zlqA-1crzA:
0.0		 1zlqA-1crzA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVV_E_MK1E902_4
(POL POLYPROTEIN)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 ARG A  14
VAL A  37
GLY A  81
 None
 0.63A 2avvE-1crzA:
0.0		 2avvE-1crzA:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JN3_A_JN3A130_2
(FATTY ACID-BINDING
PROTEIN, LIVER)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 7 LEU A 380
LEU A 393
ARG A 121
GLU A 160
 None
 0.96A 2jn3A-1crzA:
0.0		 2jn3A-1crzA:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BC9_A_ACRA901_1
(ALPHA AMYLASE,
CATALYTIC REGION)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 7 ASP A 317
SER A 360
SER A 406
ASP A 189
 None
 1.31A 3bc9A-1crzA:
undetectable		 3bc9A-1crzA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3I5U_B_SAMB401_1
(O-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 ASP A 189
PHE A 230
SER A 406
 None
 0.80A 3i5uB-1crzA:
undetectable		 3i5uB-1crzA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NV6_A_CAMA422_0
(CYTOCHROME P450)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 GLY A  81
ILE A  36
VAL A  37
 None
 0.46A 3nv6A-1crzA:
0.0		 3nv6A-1crzA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASN A 364
ALA A 362
PRO A 363
TYR A 166
 None
 1.17A 3twpD-1crzA:
2.9		 3twpD-1crzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3U88_A_CHDA611_0
(MENIN)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 SER A 320
PHE A 324
LYS A 323
 None
 0.83A 3u88A-1crzA:
0.0		 3u88A-1crzA:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_A_W9TA1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  40
VAL A  37
GLY A 124
ASP A 167
 None
 1.45A 3w9tA-1crzA:
0.0		 3w9tA-1crzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB503_1
(HEMOLYTIC LECTIN
CEL-III)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  40
VAL A  37
GLY A 124
ASP A 167
 None
 1.45A 3w9tB-1crzA:
0.0		 3w9tB-1crzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1001_1
(HEMOLYTIC LECTIN
CEL-III)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  40
VAL A  37
GLY A 124
ASP A 167
 None
 1.45A 3w9tC-1crzA:
0.0		 3w9tC-1crzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD502_1
(HEMOLYTIC LECTIN
CEL-III)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  40
VAL A  37
GLY A 124
ASP A 167
 None
 1.46A 3w9tD-1crzA:
undetectable		 3w9tD-1crzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE504_1
(HEMOLYTIC LECTIN
CEL-III)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  40
VAL A  37
GLY A 124
ASP A 167
 None
 1.45A 3w9tE-1crzA:
0.0		 3w9tE-1crzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_G_W9TG504_1
(HEMOLYTIC LECTIN
CEL-III)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ASP A  40
VAL A  37
GLY A 124
ASP A 167
 None
 1.46A 3w9tG-1crzA:
0.0		 3w9tG-1crzA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACA_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1crz TOLB PROTEIN
(Escherichia
coli) 		5 / 9 ASP A  32
ILE A  33
GLY A  34
PHE A  21
GLN A  82
 None
 1.26A 4acaB-1crzA:
undetectable
4acaC-1crzA:
undetectable		 4acaB-1crzA:
21.41
4acaC-1crzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_B_DXCB1473_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 1crz TOLB PROTEIN
(Escherichia
coli) 		5 / 8 ASP A  32
ILE A  33
GLY A  34
PHE A  21
GLN A  82
 None
 1.22A 4acbB-1crzA:
2.5
4acbC-1crzA:
2.6		 4acbB-1crzA:
21.41
4acbC-1crzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BWL_C_MN9C1297_0
(N-ACETYLNEURAMINATE
LYASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		5 / 10 ILE A  16
GLY A  13
GLY A  45
SER A  44
PHE A 142
 None
 1.20A 4bwlC-1crzA:
undetectable		 4bwlC-1crzA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 7 ALA A 147
PRO A 403
LEU A 161
LEU A 193
 None
 0.94A 4iomA-1crzA:
undetectable		 4iomA-1crzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IOM_A_FOLA608_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 7 ALA A 194
PRO A 184
LEU A 205
LEU A 237
 None
 0.94A 4iomA-1crzA:
undetectable		 4iomA-1crzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		5 / 8 ALA A 147
PRO A 403
LEU A 161
LEU A 193
TRP A 405
 None
 1.23A 4jjkA-1crzA:
undetectable		 4jjkA-1crzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JJK_A_FOLA601_0
(FORMATE--TETRAHYDROF
OLATE LIGASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 8 ALA A 194
PRO A 184
LEU A 205
LEU A 237
 None
 0.93A 4jjkA-1crzA:
undetectable		 4jjkA-1crzA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 LEU A  41
ILE A  16
ARG A  14
 None
 0.66A 4mk4B-1crzA:
undetectable		 4mk4B-1crzA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CXV_A_0HKA501_2
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M1,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M1)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 THR A 366
THR A 385
PHE A 389
 None
 0.80A 5cxvA-1crzA:
undetectable		 5cxvA-1crzA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_1
(RIBOFLAVIN
TRANSPORTER RIBU)		 1crz TOLB PROTEIN
(Escherichia
coli) 		5 / 12 ASP A 386
GLY A  45
ASN A  43
ALA A 141
ASN A 364
 None
 1.40A 5kc4E-1crzA:
undetectable		 5kc4E-1crzA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0R_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 4 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.33A 5n0rA-1crzA:
undetectable		 5n0rA-1crzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 4 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.35A 5n0sA-1crzA:
undetectable		 5n0sA-1crzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.30A 5n0tA-1crzA:
undetectable		 5n0tA-1crzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 4 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.35A 5n0wA-1crzA:
undetectable		 5n0wA-1crzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.37A 5n0wB-1crzA:
0.0		 5n0wB-1crzA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0X_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 4 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.31A 5n0xA-1crzA:
undetectable		 5n0xA-1crzA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_1
(PEPTIDE
N-METHYLTRANSFERASE)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 SER A 183
ALA A 227
GLN A 314
THR A 270
 None
 1.37A 5n4iA-1crzA:
undetectable		 5n4iA-1crzA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_A_SALA301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ALA A 127
VAL A 131
PHE A  21
ILE A  16
 None
 0.84A 5of1A-1crzA:
0.0		 5of1A-1crzA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OF1_B_SALB301_1
(SPORE
COAT-ASSOCIATED
PROTEIN N)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 5 ALA A 127
VAL A 131
PHE A  21
ILE A  16
 None
 0.85A 5of1B-1crzA:
0.0		 5of1B-1crzA:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GB9_A_ACTA508_0
(MOLYBDOPTERIN
BIOSYNTHESIS PROTEIN
CNX1)		 1crz TOLB PROTEIN
(Escherichia
coli) 		3 / 3 VAL A 107
ALA A  62
GLN A 110
 None
 0.38A 6gb9A-1crzA:
3.4		 6gb9A-1crzA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_B_AM2B301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 8 TRP A 405
ARG A 143
ASP A 129
GLU A 133
 None
 1.07A 6mn4B-1crzA:
0.0		 6mn4B-1crzA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN4_C_AM2C301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 1crz TOLB PROTEIN
(Escherichia
coli) 		4 / 8 TRP A 405
ARG A 143
ASP A 129
GLU A 133
 None
 1.22A 6mn4C-1crzA:
0.0		 6mn4C-1crzA:
21.08