SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1csj'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 5 GLU A 398
ALA A 400
SER A  27
HIS A 428
 None
 1.14A 1errA-1csjA:
0.0
1errB-1csjA:
0.3		 1errA-1csjA:
20.68
1errB-1csjA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K74_A_9CRA463_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.96A 1k74A-1csjA:
undetectable		 1k74A-1csjA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 10 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
 None
 1.38A 1qkuA-1csjA:
undetectable		 1qkuA-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 10 GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.49A 1qkuA-1csjA:
undetectable		 1qkuA-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 10 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
 None
 1.39A 1qkuB-1csjA:
undetectable		 1qkuB-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 10 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
 None
 1.38A 1qkuC-1csjA:
undetectable		 1qkuC-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 10 GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.48A 1qkuC-1csjA:
undetectable		 1qkuC-1csjA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T9U_A_CPFA5002_1
(ACRIFLAVINE
RESISTANCE PROTEIN B)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 PHE A 429
PHE A 430
ASN A 406
GLN A 438
 None
 1.13A 1t9uA-1csjA:
5.2		 1t9uA-1csjA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_E_9CRE1500_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.95A 1xdkE-1csjA:
undetectable		 1xdkE-1csjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 7 TYR A 191
GLY A 317
THR A 292
ASP A 318
 None
 1.03A 2g70A-1csjA:
undetectable		 2g70A-1csjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 7 TYR A 191
GLY A 317
THR A 292
ASP A 318
 None
 1.07A 2g70B-1csjA:
undetectable		 2g70B-1csjA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		6 / 12 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.41A 2jfaA-1csjA:
undetectable		 2jfaA-1csjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2JFA_A_RALA600_1
(ESTROGEN RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		6 / 12 ALA A  88
GLU A  87
LEU A  91
LEU A  83
LEU A  82
ILE A 253
 None
 1.37A 2jfaA-1csjA:
undetectable		 2jfaA-1csjA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QXS_A_RALA600_1
(ESTROGEN RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		6 / 12 ALA A  88
GLU A  87
LEU A  83
LEU A  82
ILE A 253
LEU A 285
 None
 1.45A 2qxsA-1csjA:
undetectable		 2qxsA-1csjA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XFH_A_CL6A1413_1
(ERYTHROMYCIN B/D
C-12 HYDROXYLASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 ALA A 393
ALA A 396
THR A 399
PHE A 429
 None
 0.93A 2xfhA-1csjA:
0.0		 2xfhA-1csjA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_B_P1BB1475_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 LEU A 489
ILE A 424
ILE A 463
LEU A 474
 None
 0.95A 2xkwB-1csjA:
0.0		 2xkwB-1csjA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_A_SAMA298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 ALA A  45
PRO A 265
THR A 267
THR A 136
LEU A  10
 None
 1.21A 2zifA-1csjA:
undetectable		 2zifA-1csjA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZUJ_A_CAMA422_0
(CAMPHOR
5-MONOOXYGENASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 8 LEU A 384
VAL A 370
VAL A 321
LEU A 314
 None
 0.75A 2zujA-1csjA:
undetectable		 2zujA-1csjA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 ALA A 174
LEU A  83
SER A  84
VAL A  85
ALA A  88
 None
 0.70A 3dcmX-1csjA:
undetectable		 3dcmX-1csjA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_A_SALA3005_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 8 ASN A 291
THR A 294
ALA A 348
SER A 347
 None
 1.01A 3kp6A-1csjA:
0.0		 3kp6A-1csjA:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N8X_B_NIMB1701_2
(PROSTAGLANDIN G/H
SYNTHASE 1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		3 / 3 VAL A  52
VAL A 161
SER A 282
 None
 0.69A 3n8xB-1csjA:
0.0		 3n8xB-1csjA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3O7W_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		3 / 3 LYS A  51
ARG A  48
ASP A 352
 None
 1.41A 3o7wA-1csjA:
undetectable		 3o7wA-1csjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHN_A_ACTA108_0
(PROTEIN P-30)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		3 / 3 THR A  41
SER A  42
ARG A  43
 None
 0.78A 3phnA-1csjA:
0.0		 3phnA-1csjA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 7 SER A 190
TYR A 296
VAL A  67
TYR A 219
 None
 1.05A 3tneB-1csjA:
undetectable		 3tneB-1csjA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_1
(PUTATIVE REGULATORY
PROTEIN)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		3 / 3 TYR A 358
MET A 313
LEU A 308
 None
 0.81A 3vw1D-1csjA:
0.3		 3vw1D-1csjA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 CYH A 295
THR A 294
ASN A 291
GLY A 317
 None
 1.25A 3w9tE-1csjA:
0.0		 3w9tE-1csjA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DQC_A_017A101_1
(ASPARTYL PROTEASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 10 ARG A 465
ALA A 416
GLY A 410
ILE A 447
ILE A 463
 None
 1.10A 4dqcA-1csjA:
undetectable		 4dqcA-1csjA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DU2_A_LDPA501_1
(CYTOCHROME P450 BM3
VARIANT B7)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 7 ALA A 246
ALA A 174
ALA A  80
LEU A  82
 None
 0.94A 4du2A-1csjA:
0.0		 4du2A-1csjA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_B_TEPB402_1
(PYRIDOXAL KINASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 5 SER A 112
HIS A 120
TYR A 103
VAL A  85
 None
 1.34A 4eohB-1csjA:
undetectable		 4eohB-1csjA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K37_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 CYH A 279
GLN A  49
LEU A 159
VAL A 161
ILE A 138
 None
 1.32A 4k37A-1csjA:
undetectable		 4k37A-1csjA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA2)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 SER A 121
GLY A 104
ASP A 107
GLY A 102
 None
 0.92A 4koeA-1csjA:
0.0
4koeB-1csjA:
0.0
4koeC-1csjA:
undetectable		 4koeA-1csjA:
21.90
4koeB-1csjA:
21.90
4koeC-1csjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KOE_H_TR6H101_1
(DNA TOPOISOMERASE 4
SUBUNIT A
DNA TOPOISOMERASE 4
SUBUNIT B
E-SITE DNA4)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 7 SER A 121
GLY A 104
ASP A 107
GLY A 102
 None
 0.95A 4koeA-1csjA:
undetectable
4koeB-1csjA:
3.9
4koeD-1csjA:
undetectable		 4koeA-1csjA:
21.90
4koeB-1csjA:
21.90
4koeD-1csjA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N09_B_ADNB401_2
(ADENOSINE KINASE)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 5 LEU A 419
SER A 478
LEU A 497
ASN A 369
 None
 1.16A 4n09B-1csjA:
undetectable		 4n09B-1csjA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qvlV-1csjA:
undetectable
4qvlb-1csjA:
2.1		 4qvlV-1csjA:
18.79
4qvlb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVL_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.15A 4qvlH-1csjA:
undetectable
4qvlN-1csjA:
undetectable		 4qvlH-1csjA:
18.79
4qvlN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qvmV-1csjA:
undetectable
4qvmb-1csjA:
2.0		 4qvmV-1csjA:
18.79
4qvmb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVM_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qvmH-1csjA:
undetectable
4qvmN-1csjA:
undetectable		 4qvmH-1csjA:
18.79
4qvmN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.19A 4qvnV-1csjA:
undetectable
4qvnb-1csjA:
undetectable		 4qvnV-1csjA:
18.79
4qvnb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.18A 4qvnH-1csjA:
undetectable
4qvnN-1csjA:
undetectable		 4qvnH-1csjA:
18.79
4qvnN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qvpV-1csjA:
undetectable
4qvpb-1csjA:
2.1		 4qvpV-1csjA:
18.79
4qvpb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVP_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qvpH-1csjA:
undetectable
4qvpN-1csjA:
undetectable		 4qvpH-1csjA:
18.79
4qvpN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qvqV-1csjA:
undetectable
4qvqb-1csjA:
2.0		 4qvqV-1csjA:
18.79
4qvqb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVQ_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qvqH-1csjA:
undetectable
4qvqN-1csjA:
undetectable		 4qvqH-1csjA:
18.79
4qvqN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qvwV-1csjA:
undetectable
4qvwb-1csjA:
undetectable		 4qvwV-1csjA:
18.79
4qvwb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qvwH-1csjA:
undetectable
4qvwN-1csjA:
undetectable		 4qvwH-1csjA:
18.79
4qvwN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qw0V-1csjA:
undetectable
4qw0b-1csjA:
2.1		 4qw0V-1csjA:
18.79
4qw0b-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW0_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qw0H-1csjA:
undetectable
4qw0N-1csjA:
undetectable		 4qw0H-1csjA:
18.79
4qw0N-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 4qw1V-1csjA:
undetectable
4qw1b-1csjA:
undetectable		 4qw1V-1csjA:
18.79
4qw1b-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.15A 4qw1H-1csjA:
undetectable
4qw1N-1csjA:
undetectable		 4qw1H-1csjA:
18.79
4qw1N-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qw3V-1csjA:
undetectable
4qw3b-1csjA:
undetectable		 4qw3V-1csjA:
18.79
4qw3b-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW3_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.17A 4qw3H-1csjA:
undetectable
4qw3N-1csjA:
undetectable		 4qw3H-1csjA:
18.79
4qw3N-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XK8_A_PQNA845_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 8 PHE A 526
ALA A 510
LEU A 511
GLY A 522
 None
 0.76A 4xk8a-1csjA:
undetectable		 4xk8a-1csjA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z53_F_TR6F101_1
(DNA TOPOISOMERASE 4
SUBUNIT B,DNA
TOPOISOMERASE 4
SUBUNIT A
E-SITE DNA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 GLY A 104
ASP A 107
GLY A 102
SER A 121
 None
 0.96A 4z53A-1csjA:
3.9
4z53B-1csjA:
4.0		 4z53A-1csjA:
21.50
4z53B-1csjA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZB_C_ACTC404_0
(PROTON-GATED ION
CHANNEL)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 4 ILE A 447
ILE A 462
ARG A 465
TYR A 452
 None
 1.23A 4zzbC-1csjA:
0.3		 4zzbC-1csjA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_C_ACTC407_0
(PROTON-GATED ION
CHANNEL)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 4 ILE A 447
ILE A 462
ARG A 465
TYR A 452
 None
 1.24A 4zzcC-1csjA:
0.2		 4zzcC-1csjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_D_ACTD406_0
(PROTON-GATED ION
CHANNEL)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 4 ILE A 447
ILE A 462
ARG A 465
TYR A 452
 None
 1.20A 4zzcD-1csjA:
0.2		 4zzcD-1csjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_E_ACTE406_0
(PROTON-GATED ION
CHANNEL)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 5 ILE A 447
ILE A 462
ARG A 465
TYR A 452
 None
 1.21A 4zzcE-1csjA:
0.2		 4zzcE-1csjA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.15A 5bxnV-1csjA:
undetectable
5bxnb-1csjA:
2.0		 5bxnV-1csjA:
18.79
5bxnb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.15A 5bxnH-1csjA:
undetectable
5bxnN-1csjA:
undetectable		 5bxnH-1csjA:
18.79
5bxnN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CZ7_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.14A 5cz7H-1csjA:
undetectable
5cz7N-1csjA:
undetectable		 5cz7H-1csjA:
18.79
5cz7N-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 5d0xV-1csjA:
undetectable
5d0xb-1csjA:
2.0		 5d0xV-1csjA:
18.79
5d0xb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 5d0xH-1csjA:
undetectable
5d0xN-1csjA:
undetectable		 5d0xH-1csjA:
18.79
5d0xN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JCN_B_ASCB502_0
(OS09G0567300 PROTEIN)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 GLU A 236
GLY A 290
ARG A 280
PHE A 224
 None
 0.98A 5jcnB-1csjA:
undetectable		 5jcnB-1csjA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K4P_A_SORA611_0
(PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 GLY A 275
THR A   7
GLY A   8
ASN A 273
 None
 0.87A 5k4pA-1csjA:
undetectable		 5k4pA-1csjA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 5l5zV-1csjA:
undetectable
5l5zb-1csjA:
2.1		 5l5zV-1csjA:
18.79
5l5zb-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5Z_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.16A 5l5zH-1csjA:
undetectable
5l5zN-1csjA:
undetectable		 5l5zH-1csjA:
18.79
5l5zN-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.15A 5l66V-1csjA:
undetectable
5l66b-1csjA:
2.1		 5l66V-1csjA:
18.79
5l66b-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L66_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 11 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.15A 5l66H-1csjA:
undetectable
5l66N-1csjA:
undetectable		 5l66H-1csjA:
18.79
5l66N-1csjA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_B_BO2B305_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.19A 5lf3b-1csjA:
undetectable		 5lf3b-1csjA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LF3_N_BO2N304_1
(PROTEASOME SUBUNIT
BETA TYPE-6)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.18A 5lf3N-1csjA:
undetectable		 5lf3N-1csjA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MWY_A_YNUA1101_0
(MINERALOCORTICOID
RECEPTOR)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 LEU A 285
LEU A 175
ALA A 252
TRP A 123
LEU A 245
 None
 1.11A 5mwyA-1csjA:
undetectable		 5mwyA-1csjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TOA_B_ESTB601_1
(ESTROGEN RECEPTOR
BETA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 LEU A 425
MET A 426
ILE A 463
LEU A 459
HIS A 467
 None
 1.09A 5toaB-1csjA:
undetectable		 5toaB-1csjA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.94A 5z12B-1csjA:
undetectable		 5z12B-1csjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z12_C_9CRC501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 ALA A 249
ALA A 174
LEU A 245
ALA A 246
LEU A 285
 None
 0.94A 5z12C-1csjA:
undetectable		 5z12C-1csjA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_B_BO2B201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.20A 6hwdV-1csjA:
undetectable
6hwdb-1csjA:
undetectable		 6hwdV-1csjA:
11.23
6hwdb-1csjA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_N_BO2N201_0
(PROTEASOME SUBUNIT
BETA TYPE-1
PROTEASOME SUBUNIT
BETA TYPE-2)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		5 / 12 THR A 136
THR A 137
GLY A 283
ALA A 281
THR A 287
 None
 1.20A 6hwdH-1csjA:
undetectable
6hwdN-1csjA:
undetectable		 6hwdH-1csjA:
11.23
6hwdN-1csjA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MA6_A_MYTA603_0
(CYTOCHROME P450 3A4)		 1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)
(Hepacivirus
C) 		4 / 6 ARG A 401
ALA A  39
THR A  41
ALA A  16
 None
 1.08A 6ma6A-1csjA:
0.0		 6ma6A-1csjA:
11.50