SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1csm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_A_AICA5001_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A  76
GLU A  82
HIS A 159
SER A 155
 None
 1.26A 1nx9A-1csmA:
undetectable		 1nx9A-1csmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_B_AICB5002_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A  76
GLU A  82
HIS A 159
SER A 155
 None
 1.25A 1nx9B-1csmA:
undetectable		 1nx9B-1csmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_C_AICC5003_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A  76
GLU A  82
HIS A 159
SER A 155
 None
 1.25A 1nx9C-1csmA:
undetectable		 1nx9C-1csmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NX9_D_AICD5004_1
(ALPHA-AMINO ACID
ESTER HYDROLASE)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		4 / 8 ARG A  76
GLU A  82
HIS A 159
SER A 155
 None
 1.25A 1nx9D-1csmA:
undetectable		 1nx9D-1csmA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_B_H4BB1001_1
(HYPOTHETICAL PROTEIN
PH0634)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		5 / 10 ILE A 117
ASP A 115
PHE A  85
THR A  83
GLU A  68
 None
 1.20A 2dttA-1csmA:
0.0
2dttB-1csmA:
0.0		 2dttA-1csmA:
20.31
2dttB-1csmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTT_F_H4BF1005_1
(HYPOTHETICAL PROTEIN
PH0634)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		5 / 9 ILE A 117
ASP A 115
PHE A  85
THR A  83
GLU A  68
 None
 1.26A 2dttE-1csmA:
0.0
2dttF-1csmA:
0.0		 2dttE-1csmA:
20.31
2dttF-1csmA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		4 / 6 LEU A 104
ILE A 103
PRO A  80
VAL A 197
 None
 1.08A 2ygoA-1csmA:
undetectable		 2ygoA-1csmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TF1_A_ACTA191_0
(METHYL-ACCEPTING
CHEMOTAXIS PROTEIN)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		4 / 5 LYS A 181
THR A 177
ILE A 180
PHE A 169
 None
 1.29A 3tf1A-1csmA:
0.0		 3tf1A-1csmA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EMA_A_BRLA601_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1csm CHORISMATE MUTASE
(Saccharomyces
cerevisiae) 		3 / 3 PHE A  28
VAL A 238
ILE A 233
 None
 0.60A 4emaA-1csmA:
0.0		 4emaA-1csmA:
24.67