SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1ct8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSD_C_DVAC2_0 (ACTINOMYCIN D)	1ct8	7C8 FAB FRAGMENT LONG CHAIN (Mus musculus)	4 / 4	THR B 116 PRO B 118 THR B 117 PRO B 147	None	1.32A	1dsdC-1ct8B: undetectable	1dsdC-1ct8B: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1DSD_C_DVAC8_0 (ACTINOMYCIN D)	1ct8	7C8 FAB FRAGMENT LONG CHAIN (Mus musculus)	4 / 4	THR B 116 PRO B 118 THR B 117 PRO B 147	None	1.32A	1dsdC-1ct8B: undetectable	1dsdC-1ct8B: 13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RG1_A_SPMA999_1 (TYROSYL-DNA PHOSPHODIESTERASE 1)	1ct8	LONG CHAIN 7C8 FAB FRAGMENT (Mus musculus)	3 / 3	TRP B 188 VAL B 211 PRO B 212	None	0.89A	1rg1A-1ct8B: 0.0	1rg1A-1ct8B: 20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1RH0_A_SPMA999_1 (TYROSYL-DNA PHOSPHODIESTERASE 1)	1ct8	LONG CHAIN 7C8 FAB FRAGMENT (Mus musculus)	3 / 3	TRP B 188 VAL B 211 PRO B 212	None	0.89A	1rh0A-1ct8B: 0.0	1rh0A-1ct8B: 20.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	5MTH_A_ACTA302_0 (ANTIBODY FAB HEAVY CHAIN)	1ct8	7C8 FAB FRAGMENT LONG CHAIN (Mus musculus)	5 / 5	SER B 112 ALA B 114 PHE B 146 LEU B 170 ASP B 173	None	1.01A	5mthA-1ct8B: 30.0	5mthA-1ct8B: 77.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TL8_A_X2NA502_1 (PROTEIN CYP51)	1ct8	LONG CHAIN 7C8 FAB FRAGMENT (Mus musculus)	5 / 12	ALA B 16 PHE B 146 TYR B 145 LEU B 108 THR B 83	None	1.10A	5tl8A-1ct8B: undetectable	5tl8A-1ct8B: 22.83

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1DSD_C_DVAC2_0","ACTINOMYCIN D","1ct8","7C8 FAB FRAGMENT; LONG CHAIN","Mus musculus",4,"THR B 116;PRO B 118;THR B 117;PRO B 147","None","1.32A","1dsdC-1ct8B:undetectable","1dsdC-1ct8B:13.33"],["1DSD_C_DVAC8_0","ACTINOMYCIN D","1ct8","7C8 FAB FRAGMENT; LONG CHAIN","Mus musculus",4,"THR B 116;PRO B 118;THR B 117;PRO B 147","None","1.32A","1dsdC-1ct8B:undetectable","1dsdC-1ct8B:13.33"],["1RG1_A_SPMA999_1","TYROSYL-DNA PHOSPHODIESTERASE 1","1ct8"," LONG CHAIN;7C8 FAB FRAGMENT","Mus musculus",3,"TRP B 188;VAL B 211;PRO B 212","None","0.89A","1rg1A-1ct8B:0.0","1rg1A-1ct8B:20.88"],["1RH0_A_SPMA999_1","TYROSYL-DNA PHOSPHODIESTERASE 1","1ct8"," LONG CHAIN;7C8 FAB FRAGMENT","Mus musculus",3,"TRP B 188;VAL B 211;PRO B 212","None","0.89A","1rh0A-1ct8B:0.0","1rh0A-1ct8B:20.88"],["5MTH_A_ACTA302_0","ANTIBODY FAB HEAVY CHAIN","1ct8","7C8 FAB FRAGMENT; LONG CHAIN","Mus musculus",5,"SER B 112;ALA B 114;PHE B 146;LEU B 170;ASP B 173","None","1.01A","5mthA-1ct8B:30.0","5mthA-1ct8B:77.38"],["5TL8_A_X2NA502_1","PROTEIN CYP51","1ct8"," LONG CHAIN;7C8 FAB FRAGMENT","Mus musculus",5,"ALA B  16;PHE B 146;TYR B 145;LEU B 108;THR B  83","None","1.10A","5tl8A-1ct8B:undetectable","5tl8A-1ct8B:22.83"]]