SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cte'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 8 ASP A 143
SER A  39
VAL A  52
GLY A  91
GLY A  99
 None
 1.28A 1aq7A-1cteA:
undetectable		 1aq7A-1cteA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AQ7_B_AG2B4_1
(TRYPSIN
AERUGINOSIN 98-B)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 8 SER A  90
SER A  39
VAL A  52
GLY A  92
GLY A  99
 None
 1.12A 1aq7A-1cteA:
undetectable		 1aq7A-1cteA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MJQ_G_SAMG199_0
(METHIONINE REPRESSOR)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 10 GLU A  36
ALA A 200
HIS A 199
PHE A  32
GLY A  27
 None
None
PYS  A 255 ( 4.1A)
None
None
 1.25A 1mjqG-1cteA:
undetectable
1mjqH-1cteA:
undetectable		 1mjqG-1cteA:
16.87
1mjqH-1cteA:
16.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1STF_E_CCSE25_0
(PAPAIN
STEFIN B (CYSTATIN
B))		 1cte CATHEPSIN B
(Rattus
norvegicus) 		6 / 10 GLN A  23
GLY A  27
SER A  28
TRP A  30
PHE A  32
ALA A 200
 PYS  A 255 (-2.9A)
None
None
None
None
None
 0.42A 1stfE-1cteA:
27.2
1stfI-1cteA:
0.0		 1stfE-1cteA:
31.03
1stfI-1cteA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TNL_A_TPAA900_1
(TRYPSIN)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 6 SER A  90
SER A  39
VAL A  52
GLY A  92
GLY A  99
 None
 1.09A 1tnlA-1cteA:
undetectable		 1tnlA-1cteA:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		3 / 3 GLU A 243
GLU A 159
LEU A   1
 None
 0.70A 1v8bA-1cteA:
undetectable		 1v8bA-1cteA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1V8B_B_ADNB1502_2
(ADENOSYLHOMOCYSTEINA
SE)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		3 / 3 GLU A 243
GLU A 159
LEU A   1
 None
 0.72A 1v8bB-1cteA:
undetectable		 1v8bB-1cteA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AVD_A_SAMA501_0
(CATECHOL-O-METHYLTRA
NSFERASE)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 12 GLY A  33
SER A 220
VAL A 247
ALA A  79
ALA A  34
 None
PYS  A 255 ( 3.8A)
None
None
None
 1.49A 2avdA-1cteA:
undetectable		 2avdA-1cteA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DTJ_B_THRB402_0
(ASPARTOKINASE)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 9 ASN A 238
ILE A 242
ILE A 160
ASP A 155
GLY A 236
 None
 1.37A 2dtjA-1cteA:
undetectable
2dtjB-1cteA:
undetectable		 2dtjA-1cteA:
21.24
2dtjB-1cteA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OTV_A_NCAA1301_0
(CATIONIC TRYPSIN)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 6 SER A  90
SER A  39
VAL A  52
GLY A  92
GLY A  99
 None
 1.13A 2otvA-1cteA:
undetectable		 2otvA-1cteA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 7 GLN A  23
GLY A  27
HIS A 110
HIS A 111
TRP A 221
 PYS  A 255 (-2.9A)
None
None
None
PYS  A 255 (-4.0A)
 0.30A 3ai8A-1cteA:
45.8		 3ai8A-1cteA:
82.42
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3AI8_B_HNQB255_1
(CATHEPSIN B)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		5 / 6 GLN A  23
GLY A  27
HIS A 110
HIS A 111
TRP A 221
 PYS  A 255 (-2.9A)
None
None
None
PYS  A 255 (-4.0A)
 0.23A 3ai8B-1cteA:
45.8		 3ai8B-1cteA:
82.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RZV_A_032A801_2
(SERINE/THREONINE-PRO
TEIN KINASE B-RAF)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		4 / 5 ILE A 201
VAL A 217
CYH A 240
HIS A 199
 PYS  A 255 (-4.6A)
None
None
PYS  A 255 ( 4.1A)
 1.13A 4rzvA-1cteA:
0.0		 4rzvA-1cteA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4H_A_IPHA904_0
(PROTEIN ARGONAUTE-2)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		4 / 5 GLN A  19
PRO A  15
ILE A  17
ASP A  40
 None
 1.50A 4z4hA-1cteA:
undetectable		 4z4hA-1cteA:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X23_A_LSNA503_1
(CYTOCHROME P450 2C9)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		4 / 5 PRO A 169
GLY A 168
ASN A 167
LYS A 166
 None
 1.24A 5x23A-1cteA:
0.0		 5x23A-1cteA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X80_B_SALB203_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RV2887)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		4 / 6 PRO A  76
GLY A  78
TYR A  75
VAL A 247
 None
 0.96A 5x80A-1cteA:
0.0
5x80B-1cteA:
0.0		 5x80A-1cteA:
18.70
5x80B-1cteA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA409_0
(UNCHARACTERIZED
PROTEIN KDOO)		 1cte CATHEPSIN B
(Rattus
norvegicus) 		3 / 3 ASP A   6
PHE A 230
ARG A 202
 None
 1.05A 5yw0A-1cteA:
0.0		 5yw0A-1cteA:
20.06