SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cu1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AKD_A_CAMA420_0
(CYTOCHROME P450CAM)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 11 LEU A  82
VAL A  83
GLY A  84
VAL A  36
VAL A 707
 None
 1.28A 1akdA-1cu1A:
0.0		 1akdA-1cu1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_B_CUB4_0
(BETA-CARBONIC
ANHYDRASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 6 CYH A  99
CYH A 145
PRO A 146
SER A 147
 ZN  A 999 (-2.3A)
ZN  A 999 (-2.3A)
None
ZN  A 999 ( 4.3A)
 0.93A 1ekjA-1cu1A:
1.0
1ekjB-1cu1A:
1.1		 1ekjA-1cu1A:
16.32
1ekjB-1cu1A:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHQ_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 8 THR A 305
GLY A 304
GLY A 271
PHE A 273
LEU A 274
 None
 1.43A 1jhqA-1cu1A:
undetectable		 1jhqA-1cu1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHV_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 8 THR A 305
GLY A 304
GLY A 271
PHE A 273
LEU A 274
 None
 1.49A 1jhvA-1cu1A:
0.2		 1jhvA-1cu1A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_2
(POL POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 ARG A 464
VAL A 389
GLY A 404
ILE A 403
VAL A 408
 None
 0.98A 1k6cB-1cu1A:
undetectable		 1k6cB-1cu1A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOJ_C_FRDC305_2
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 7 ASP A 296
GLY A 302
ILE A 303
VAL A 490
 None
 0.79A 2aojB-1cu1A:
1.4		 2aojB-1cu1A:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXG_A_IBPA2002_1
(SERUM ALBUMIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 8 ALA A 204
ALA A 321
GLU A 291
VAL A 214
 None
 0.89A 2bxgA-1cu1A:
1.6		 2bxgA-1cu1A:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2FB2_A_SAMA501_0
(MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 8 CYH A 525
THR A 435
GLU A 493
THR A 433
 None
 1.05A 2fb2A-1cu1A:
undetectable		 2fb2A-1cu1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IGT_C_SAMC1003_1
(SAM DEPENDENT
METHYLTRANSFERASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 4 ASP A 168
ASP A 121
ASP A  81
GLY A 152
 None
 1.20A 2igtC-1cu1A:
3.4		 2igtC-1cu1A:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_A_SC2A1290_1
(FICOLIN-2)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 5 SER A 231
LEU A 414
GLY A 417
ARG A 464
 None
 1.24A 2j2pA-1cu1A:
0.0
2j2pB-1cu1A:
undetectable		 2j2pA-1cu1A:
14.62
2j2pB-1cu1A:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OC8_A_HU5A999_1
(HEPATITIS C VIRUS)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		11 / 12 GLN A  41
HIS A  57
ARG A 123
LEU A 135
GLY A 137
SER A 139
PHE A 154
ARG A 155
ALA A 156
ALA A 157
VAL A 158
 None
 0.76A 2oc8A-1cu1A:
31.2		 2oc8A-1cu1A:
29.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 ALA A  45
LEU A  64
SER A 706
THR A  10
THR A  54
 None
 1.26A 2oipB-1cu1A:
undetectable		 2oipB-1cu1A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PIW_A_T3A932_1
(ANDROGEN RECEPTOR)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 6 LEU A 381
VAL A 409
ILE A 366
ILE A 347
 None
 0.82A 2piwA-1cu1A:
undetectable		 2piwA-1cu1A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Q6O_A_SAMA500_0
(HYPOTHETICAL PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 7 ASP A 296
ALA A 497
PRO A 230
THR A 269
 None
 1.04A 2q6oA-1cu1A:
undetectable		 2q6oA-1cu1A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZTH_A_SAMA305_0
(CATECHOL
O-METHYLTRANSFERASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 VAL A 116
GLY A 152
TYR A 105
SER A 174
GLN A  80
 None
 1.50A 2zthA-1cu1A:
3.8		 2zthA-1cu1A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1271_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 7A1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 6 GLN A 460
PHE A 367
LEU A 365
PHE A 422
 None
 1.14A 3ablP-1cu1A:
0.2
3ablW-1cu1A:
0.0		 3ablP-1cu1A:
18.31
3ablW-1cu1A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZV_B_AZMB263_1
(CARBONIC ANHYDRASE
13)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 10 GLN A  41
VAL A 707
THR A  54
VAL A  55
TRP A  85
 None
 1.31A 3czvB-1cu1A:
undetectable		 3czvB-1cu1A:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GGU_B_017B201_1
(PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 LEU A 365
VAL A 389
GLY A 404
ILE A 403
VAL A 408
 None
 1.18A 3gguA-1cu1A:
undetectable		 3gguA-1cu1A:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JZJ_A_ACRA405_1
(ACARBOSE/MALTOSE
BINDING PROTEIN GACH)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 GLY A 271
ALA A 234
ASP A 296
GLY A 417
ASN A 229
 None
 1.32A 3jzjA-1cu1A:
0.0		 3jzjA-1cu1A:
21.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
PHE A 154
ALA A 156
ALA A 157
CYH A 159
ASP A 168
 None
 0.55A 3keeA-1cu1A:
32.1		 3keeA-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_A_30BA500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 157
CYH A 159
ASP A 168
 None
 0.65A 3keeA-1cu1A:
32.1		 3keeA-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_A_30BA500_2
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 4 GLN A  41
PHE A  43
TYR A  56
VAL A 132
 None
 0.53A 3keeA-1cu1A:
32.1		 3keeA-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
VAL A 132
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.61A 3keeB-1cu1A:
32.3		 3keeB-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_B_30BB500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
ASP A  81
VAL A 132
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.64A 3keeB-1cu1A:
32.3		 3keeB-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_B_30BB500_2
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 PHE A  43
TYR A  56
LEU A 135
 None
 0.38A 3keeB-1cu1A:
32.3		 3keeB-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 HIS A  57
GLY A  58
ASP A  81
VAL A 132
LYS A 136
GLY A 137
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.55A 3keeC-1cu1A:
32.1		 3keeC-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_C_30BC500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 HIS A  57
GLY A  58
ASP A  81
VAL A 132
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 157
ASP A 168
 None
 0.65A 3keeC-1cu1A:
32.1		 3keeC-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_C_30BC500_2
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 4 GLN A  41
PHE A  43
TYR A  56
LEU A 135
 None
 0.55A 3keeC-1cu1A:
32.1		 3keeC-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.55A 3keeD-1cu1A:
32.3		 3keeD-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_D_30BD500_1
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		7 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
ASP A 168
 None
 0.75A 3keeD-1cu1A:
32.3		 3keeD-1cu1A:
32.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3KEE_D_30BD500_2
(GENOME POLYPROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 4 PHE A  43
TYR A  56
VAL A 132
LEU A 135
 None
 0.43A 3keeD-1cu1A:
32.3		 3keeD-1cu1A:
32.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MTE_B_SAMB220_0
(16S RRNA METHYLASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 GLY A 141
VAL A  55
ALA A 156
ALA A 157
LEU A 135
 None
 1.00A 3mteB-1cu1A:
undetectable		 3mteB-1cu1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NU9_A_478A401_2
(PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 10 LEU A 365
VAL A 389
GLY A 404
ILE A 403
VAL A 408
 None
 1.12A 3nu9B-1cu1A:
undetectable		 3nu9B-1cu1A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_C_SAMC6735_0
(16S RRNA METHYLASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 GLY A 141
VAL A  55
ALA A 156
ALA A 157
LEU A 135
 None
 1.02A 3p2kC-1cu1A:
undetectable		 3p2kC-1cu1A:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 LEU A 144
ARG A  92
ASN A  49
 None
 0.77A 3qxvD-1cu1A:
undetectable		 3qxvD-1cu1A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SPK_B_TPVB100_1
(HIV-1 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 9 ARG A 464
LEU A 365
VAL A 389
GLY A 404
ILE A 403
 None
 1.22A 3spkA-1cu1A:
undetectable		 3spkA-1cu1A:
9.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.54A 3sudA-1cu1A:
34.6		 3sudA-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
 None
 0.49A 3sudB-1cu1A:
34.9		 3sudB-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.57A 3sudC-1cu1A:
33.8		 3sudC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUD_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
ASP A 168
 None
 0.62A 3sudD-1cu1A:
34.6		 3sudD-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.66A 3sueA-1cu1A:
34.8		 3sueA-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		8 / 12 HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
SER A 139
ALA A 156
ALA A 157
 None
 0.69A 3sueA-1cu1A:
34.8		 3sueA-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 4 PHE A  43
TYR A  56
ARG A 123
LEU A 135
 None
 0.45A 3sueA-1cu1A:
34.8		 3sueA-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.62A 3sueB-1cu1A:
34.8		 3sueB-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		8 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.71A 3sueB-1cu1A:
34.8		 3sueB-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_B_SUEB1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 PHE A  43
TYR A  56
LEU A 135
 None
 0.20A 3sueB-1cu1A:
34.8		 3sueB-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.62A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ASP A 168
 None
 0.90A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.74A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ASP A 168
 None
 0.99A 3sueC-1cu1A:
34.4		 3sueC-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
PHE A  43
HIS A  57
GLY A  58
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
 None
 0.52A 3sueD-1cu1A:
34.7		 3sueD-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		8 / 12 GLN A  41
PHE A  43
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
 None
 0.65A 3sueD-1cu1A:
34.7		 3sueD-1cu1A:
80.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
LEU A 135
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.54A 3sufA-1cu1A:
34.4		 3sufA-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
ARG A 123
LYS A 136
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.65A 3sufA-1cu1A:
34.4		 3sufA-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.65A 3sufA-1cu1A:
34.4		 3sufA-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
ASP A  81
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.76A 3sufA-1cu1A:
34.4		 3sufA-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.55A 3sufB-1cu1A:
34.8		 3sufB-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
PHE A  43
VAL A  55
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 157
 None
 0.70A 3sufB-1cu1A:
34.8		 3sufB-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_B_SUEB1201_3
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 5 SER A 128
ARG A 130
PRO A 131
TYR A 134
VAL A 163
 None
 0.61A 3sufC-1cu1A:
34.0		 3sufC-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_C_SUEC1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		11 / 11 GLN A  41
PHE A  43
TYR A  56
HIS A  57
GLY A  58
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
 None
 0.68A 3sufC-1cu1A:
34.0		 3sufC-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUF_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		11 / 12 VAL A  55
HIS A  57
GLY A  58
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
CYH A 159
 None
 0.53A 3sufD-1cu1A:
32.6		 3sufD-1cu1A:
81.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
VAL A  78
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 157
ASP A 168
 None
 0.76A 3sugA-1cu1A:
34.9		 3sugA-1cu1A:
80.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		8 / 12 HIS A  57
VAL A  78
ARG A 123
GLY A 137
PHE A 154
ARG A 155
ALA A 157
ASP A 168
 None
 0.99A 3sugA-1cu1A:
34.9		 3sugA-1cu1A:
80.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3SUG_A_SUEA1201_2
(NS3 PROTEASE, NS4A
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 5 GLN A  41
PHE A  43
TYR A  56
LEU A 135
 None
 0.58A 3sugA-1cu1A:
34.9		 3sugA-1cu1A:
80.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TTR_A_LQZA90_1
(LACTOTRANSFERRIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 PRO A 520
THR A 519
LEU A 320
 None
 0.77A 3ttrA-1cu1A:
0.2		 3ttrA-1cu1A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_B_ADNB301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 10 ARG A 512
GLY A 304
LEU A 228
LEU A 307
ILE A 287
 None
 1.10A 3wdmB-1cu1A:
undetectable		 3wdmB-1cu1A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E0F_A_RBFA301_1
(RIBOFLAVIN SYNTHASE
SUBUNIT ALPHA)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 11 SER A 424
VAL A 408
LEU A 365
ALA A 410
VAL A 389
 None
 1.25A 4e0fA-1cu1A:
0.0		 4e0fA-1cu1A:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LL3_A_017A201_1
(PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 8 ALA A 315
ASP A 285
GLY A 281
ILE A 287
 None
 0.74A 4ll3A-1cu1A:
1.3		 4ll3A-1cu1A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_B_BO2B201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 11 THR A  38
THR A  40
LYS A  62
GLY A  58
THR A  54
 None
 1.28A 4qwuV-1cu1A:
undetectable
4qwub-1cu1A:
undetectable		 4qwuV-1cu1A:
17.85
4qwub-1cu1A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWU_N_BO2N201_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-1)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 11 THR A  38
THR A  40
LYS A  62
GLY A  58
THR A  54
 None
 1.28A 4qwuH-1cu1A:
undetectable
4qwuN-1cu1A:
undetectable		 4qwuH-1cu1A:
17.85
4qwuN-1cu1A:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4U14_A_0HKA2000_1
(MUSCARINIC
ACETYLCHOLINE
RECEPTOR
M3,ENDOLYSIN,MUSCARI
NIC ACETYLCHOLINE
RECEPTOR M3)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 ILE A 288
SER A 211
THR A 416
ALA A 233
TYR A 270
 None
PO4  A 800 (-4.6A)
None
None
None
 1.12A 4u14A-1cu1A:
0.0		 4u14A-1cu1A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XP6_A_B40A601_1
(TRANSPORTER)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 5 ASP A 296
VAL A 456
ASP A 454
GLY A 484
 None
 1.18A 4xp6A-1cu1A:
0.0		 4xp6A-1cu1A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XTA_A_DIFA501_1
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 9 ALA A 157
LEU A 106
LEU A 143
ILE A 153
 None
 0.97A 4xtaA-1cu1A:
undetectable		 4xtaA-1cu1A:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_A_ACTA1923_0
(BETA-XYLOSIDASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 ASP A 285
ARG A 316
TYR A 223
 None
 0.73A 5a7mA-1cu1A:
undetectable		 5a7mA-1cu1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A7M_B_ACTB1924_0
(BETA-XYLOSIDASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 ASP A 285
ARG A 316
TYR A 223
 None
 0.73A 5a7mB-1cu1A:
2.1		 5a7mB-1cu1A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC306_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 6 GLN A 460
PHE A 367
LEU A 365
PHE A 422
 None
 1.05A 5b1bC-1cu1A:
0.2
5b1bJ-1cu1A:
0.0		 5b1bC-1cu1A:
18.31
5b1bJ-1cu1A:
5.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B6I_A_ADNA302_1
(FLUORINASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 7 ASP A 296
THR A 299
PRO A 230
THR A 269
 None
 0.87A 5b6iA-1cu1A:
undetectable		 5b6iA-1cu1A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDN_P_EVPP2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 6 SER A 297
GLU A 493
GLY A 277
ASP A 276
 None
 0.93A 5cdnT-1cu1A:
0.0
5cdnU-1cu1A:
2.2		 5cdnT-1cu1A:
21.43
5cdnU-1cu1A:
13.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HWA_A_GCSA301_1
(CHITOSANASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 8 ILE A 713
GLY A 141
THR A  46
LEU A 143
 None
 0.80A 5hwaA-1cu1A:
0.0		 5hwaA-1cu1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L1F_D_6ZPD902_1
(GLUTAMATE RECEPTOR 2)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 10 SER A 439
PHE A 444
ASP A 441
PRO A 442
LEU A 598
 None
 1.48A 5l1fD-1cu1A:
3.7		 5l1fD-1cu1A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 CYH A 499
LEU A 560
ILE A 542
LEU A 513
LEU A 301
 None
 1.49A 5ycpA-1cu1A:
0.0		 5ycpA-1cu1A:
8.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
PHE A  43
HIS A  57
GLY A  58
VAL A  78
ARG A 123
LEU A 135
GLY A 137
PHE A 154
ALA A 156
 None
 0.55A 6c2mA-1cu1A:
34.7		 6c2mA-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
PHE A  43
HIS A  57
GLY A  58
VAL A  78
LEU A 135
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.63A 6c2mA-1cu1A:
34.7		 6c2mA-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_A_SUEA1202_1
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		6 / 9 VAL A  55
ASP A  81
LYS A 136
ALA A 157
VAL A 158
ASP A 168
 None
 0.71A 6c2mA-1cu1A:
34.7		 6c2mA-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		6 / 12 GLN A  41
HIS A  57
VAL A 524
LYS A 136
GLY A 137
PHE A 154
 None
 1.45A 6c2mB-1cu1A:
34.9		 6c2mB-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
PHE A  43
HIS A  57
GLY A  58
VAL A  78
ARG A 123
LYS A 136
GLY A 137
PHE A 154
ALA A 156
 None
 0.73A 6c2mB-1cu1A:
34.9		 6c2mB-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
PHE A  43
HIS A  57
GLY A  58
VAL A  78
LYS A 136
GLY A 137
SER A 139
PHE A 154
ALA A 156
 None
 0.81A 6c2mB-1cu1A:
34.9		 6c2mB-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		6 / 9 VAL A  55
ASP A  81
LEU A 135
ALA A 157
VAL A 158
ASP A 168
 None
 0.34A 6c2mB-1cu1A:
34.9		 6c2mB-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
VAL A  78
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.57A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		10 / 12 GLN A  41
HIS A  57
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.62A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_C_SUEC1203_1
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 9 PHE A  43
VAL A  55
GLY A  58
LEU A 135
ASP A 168
 None
 0.27A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.64A 6c2mD-1cu1A:
34.4		 6c2mD-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_D_SUED1202_0
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		9 / 12 HIS A  57
GLY A  58
VAL A  78
ARG A 123
LYS A 136
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.52A 6c2mD-1cu1A:
34.4		 6c2mD-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6C2M_D_SUED1202_1
(NS3 PROTEASE)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		6 / 9 PHE A  43
VAL A  55
ASP A  81
LEU A 135
VAL A 158
ASP A 168
 None
 0.38A 6c2mD-1cu1A:
34.4		 6c2mD-1cu1A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 ARG A 467
ARG A 469
ASP A 421
 None
 0.98A 6d8pA-1cu1A:
0.0		 6d8pA-1cu1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_A_ACTA816_0
(UNCHARACTERIZED
PROTEIN)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		3 / 3 ARG A 469
ARG A 467
ASP A 421
 None
 0.81A 6d8pA-1cu1A:
0.0		 6d8pA-1cu1A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DYO_A_LDPA901_0
(EBONY)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		4 / 5 VAL A 318
LEU A 320
HIS A 203
THR A 519
 None
 1.25A 6dyoA-1cu1A:
0.0		 6dyoA-1cu1A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GNG_B_QPSB601_1
(-)		 1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)
(Hepacivirus
C) 		5 / 12 THR A 443
PRO A 506
VAL A 629
CYH A 159
GLY A 162
 None
 1.49A 6gngB-1cu1A:
undetectable		 6gngB-1cu1A:
22.02