SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cv8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_B_ACTB1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		3 / 3 PRO A  81
GLY A  74
TYR A 174
 None
 0.72A 2vouB-1cv8A:
undetectable		 2vouB-1cv8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VOU_C_ACTC1391_0
(2,6-DIHYDROXYPYRIDIN
E HYDROXYLASE)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		3 / 3 PRO A  81
GLY A  74
TYR A 174
 None
 0.73A 2vouC-1cv8A:
undetectable		 2vouC-1cv8A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		4 / 4 ALA A  35
TYR A  37
ALA A  31
TYR A  42
 None
 1.18A 2wlkA-1cv8A:
undetectable
2wlkB-1cv8A:
undetectable		 2wlkA-1cv8A:
17.28
2wlkB-1cv8A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y6R_B_CTCB1385_0
(TETX2 PROTEIN)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		4 / 8 GLN A  18
GLY A  22
GLY A 107
MET A  70
 E64  A 176 (-3.3A)
E64  A 176 (-3.2A)
None
E64  A 176 ( 3.8A)
 0.88A 2y6rB-1cv8A:
undetectable		 2y6rB-1cv8A:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AI8_A_HNQA255_1
(CATHEPSIN B)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		4 / 7 GLN A  18
GLY A  22
HIS A 120
TRP A 143
 E64  A 176 (-3.3A)
E64  A 176 (-3.2A)
E64  A 176 ( 3.7A)
None
 0.49A 3ai8A-1cv8A:
12.4		 3ai8A-1cv8A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_C_ACTC4_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		4 / 4 GLY A 173
GLY A 102
THR A  36
LEU A  33
 None
 0.84A 3si7C-1cv8A:
0.0
3si7D-1cv8A:
0.0		 3si7C-1cv8A:
18.42
3si7D-1cv8A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SU9_A_ACTA426_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		3 / 3 GLN A   4
GLU A 135
LYS A 129
 None
 1.19A 3su9A-1cv8A:
0.0		 3su9A-1cv8A:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3THR_A_C2FA1100_1
(GLYCINE
N-METHYLTRANSFERASE)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		3 / 3 LEU A  51
HIS A  52
MET A  48
 None
E64  A 176 (-4.4A)
None
 0.95A 3thrD-1cv8A:
undetectable		 3thrD-1cv8A:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DTA_A_ADNA401_1
(APH(2'')-ID)		 1cv8 STAPHOPAIN
(Staphylococcus
aureus) 		5 / 10 ALA A  25
PRO A  81
ILE A  71
LEU A  83
ILE A 171
 E64  A 176 ( 4.1A)
None
None
None
None
 1.33A 4dtaA-1cv8A:
undetectable		 4dtaA-1cv8A:
21.48