SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '1cvm'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID
Hit
Macromolecule
Res.
Matches
Interface HETATM RMSD Dali
Z-score
Seq.
Identity (%)
View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.80A 1p7lD-1cvmA:
undetectable
1p7lD-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.78A 1p7lC-1cvmA:
0.0
1p7lC-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.81A 1rg9B-1cvmA:
undetectable
1rg9B-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.82A 1rg9A-1cvmA:
0.0
1rg9A-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.80A 1rg9D-1cvmA:
undetectable
1rg9D-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.79A 1rg9C-1cvmA:
undetectable
1rg9C-1cvmA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A1M_A_CAMA1422_0
(CYTOCHROME P450-CAM)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 TYR A 284
THR A 313
GLY A 309
THR A 307
None
None
CA  A 802 (-4.3A)
None
0.90A 2a1mA-1cvmA:
0.0
2a1mA-1cvmA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_A_ZMRA1478_1
(NEURAMINIDASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 SER A 283
ASP A 298
SER A 278
ASN A 281
None
1.14A 2cmlA-1cvmA:
8.0
2cmlA-1cvmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_C_ZMRC3478_1
(NEURAMINIDASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 SER A 283
ASP A 298
SER A 278
ASN A 281
None
1.01A 2cmlC-1cvmA:
13.7
2cmlC-1cvmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CML_D_ZMRD4478_1
(NEURAMINIDASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 SER A 283
ASP A 298
SER A 278
ASN A 281
None
1.10A 2cmlD-1cvmA:
14.0
2cmlD-1cvmA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_A_SAMA2001_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 TYR A 284
GLY A 315
THR A 313
ASP A  56
None
None
None
CA  A 803 (-2.5A)
1.08A 2g70A-1cvmA:
undetectable
2g70A-1cvmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2G70_B_SAMB2002_1
(PHENYLETHANOLAMINE
N-METHYLTRANSFERASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 TYR A 284
GLY A 315
THR A 313
ASP A  56
None
None
None
CA  A 803 (-2.5A)
1.05A 2g70B-1cvmA:
undetectable
2g70B-1cvmA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PGR_A_DCFA501_2
(ADENOSINE DEAMINASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
3 / 3 LEU A 163
LEU A 141
PHE A 161
None
0.68A 2pgrA-1cvmA:
undetectable
2pgrA-1cvmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCJ_B_THHB401_0
(PROBABLE
5'-PHOSPHORIBOSYLGLY
CINAMIDE
FORMYLTRANSFERASE
PURN)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ILE A 316
LEU A 275
THR A 310
GLY A 261
None
0.83A 3dcjB-1cvmA:
undetectable
3dcjB-1cvmA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVR_A_URFA2001_1
(URIDINE
PHOSPHORYLASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 10 THR A 177
PHE A 204
GLU A 184
LEU A 222
ILE A 224
None
1.27A 3kvrA-1cvmA:
undetectable
3kvrA-1cvmA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TQB_A_FOLA2001_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 11 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
1.12A 3tqbA-1cvmA:
undetectable
3tqbA-1cvmA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ILE A 259
LEU A 262
LEU A 274
GLY A 252
ASP A 251
None
1.06A 3vaqB-1cvmA:
undetectable
3vaqB-1cvmA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAS_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ILE A 259
LEU A 262
LEU A 274
GLY A 252
ASP A 251
None
1.04A 3vasB-1cvmA:
undetectable
3vasB-1cvmA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 TYR A 159
GLY A 315
GLY A 261
LEU A 262
GLU A 227
CD  A 811 (-4.9A)
None
None
None
CD  A 811 (-3.2A)
1.08A 3vywA-1cvmA:
undetectable
3vywA-1cvmA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEV_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 ASP A  52
ASN A  99
GLU A 157
ASP A 314
CD  A 814 (-3.9A)
CD  A 813 ( 4.1A)
None
CD  A 814 (-2.6A)
1.17A 4fevB-1cvmA:
0.0
4fevB-1cvmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FEW_B_KANB301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 ASP A  52
ASN A  99
GLU A 157
ASP A 314
CD  A 814 (-3.9A)
CD  A 813 ( 4.1A)
None
CD  A 814 (-2.6A)
1.21A 4fewB-1cvmA:
undetectable
4fewB-1cvmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
0.94A 4fhbA-1cvmA:
undetectable
4fhbA-1cvmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4GKH_D_KAND301_1
(AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E APHA1-IAB)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ASP A  52
ASN A  99
GLU A 157
ASP A 314
CD  A 814 (-3.9A)
CD  A 813 ( 4.1A)
None
CD  A 814 (-2.6A)
1.20A 4gkhD-1cvmA:
undetectable
4gkhD-1cvmA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV0_B_SAMB302_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ILE A 316
GLY A 212
GLY A 261
ILE A 231
ILE A 224
None
1.16A 4iv0B-1cvmA:
undetectable
4iv0B-1cvmA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_A_SAMA405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.76A 4kttB-1cvmA:
undetectable
4kttB-1cvmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KTT_C_SAMC404_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.78A 4kttD-1cvmA:
undetectable
4kttD-1cvmA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_A_8PRA603_1
(TRANSPORTER)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ASP A 217
ALA A 267
TYR A 266
GLY A 270
ASP A 373
None
1.26A 4mm4A-1cvmA:
undetectable
4mm4A-1cvmA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_A_SAMA407_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.76A 4ndnB-1cvmA:
undetectable
4ndnB-1cvmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NDN_C_SAMC405_1
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.76A 4ndnD-1cvmA:
undetectable
4ndnD-1cvmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX6_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
1.01A 4nx6A-1cvmA:
undetectable
4nx6A-1cvmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NX7_A_FOLA202_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
0.99A 4nx7A-1cvmA:
undetectable
4nx7A-1cvmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P3R_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
1.01A 4p3rA-1cvmA:
undetectable
4p3rA-1cvmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PST_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
0.98A 4pstA-1cvmA:
undetectable
4pstA-1cvmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PTJ_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
1.04A 4ptjA-1cvmA:
undetectable
4ptjA-1cvmA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5G_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
1.01A 4x5gB-1cvmA:
undetectable
4x5gB-1cvmA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XI3_D_29SD601_2
(ESTROGEN RECEPTOR)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
3 / 3 LEU A 262
ASP A  56
ILE A 286
None
CA  A 803 (-2.5A)
None
0.71A 4xi3D-1cvmA:
0.0
4xi3D-1cvmA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 12 ALA A 119
LEU A 163
THR A 145
ILE A 196
ILE A 151
None
1.09A 5e8qA-1cvmA:
undetectable
5e8qA-1cvmA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HRQ_E_IPHE101_0
(INSULIN A-CHAIN
INSULIN B-CHAIN)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 ILE A 247
HIS A 254
LEU A 255
ALA A 285
None
0.93A 5hrqE-1cvmA:
undetectable
5hrqF-1cvmA:
undetectable
5hrqJ-1cvmA:
undetectable
5hrqE-1cvmA:
4.84
5hrqF-1cvmA:
6.07
5hrqJ-1cvmA:
6.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 10 LEU A 188
ILE A 131
ALA A 118
PHE A 161
PRO A 238
None
1.22A 5m0oA-1cvmA:
0.0
5m0oA-1cvmA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T8S_B_SAMB402_0
(S-ADENOSYLMETHIONINE
SYNTHASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.81A 5t8sA-1cvmA:
undetectable
5t8sA-1cvmA:
24.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_1
(NS3 PROTEASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
5 / 9 LEU A 262
ARG A 289
ALA A 214
SER A 162
ASP A 216
None
1.38A 6c2mB-1cvmA:
0.0
6c2mB-1cvmA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C71_B_NCTB501_1
(AMINE OXIDASE)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 8 LEU A  80
TYR A 132
GLU A 130
THR A  74
None
1.25A 6c71B-1cvmA:
undetectable
6c71B-1cvmA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FBN_B_SAMB401_0
(S-ADENOSYLMETHIONINE
SYNTHASE ISOFORM
TYPE-2)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 7 ALA A 174
ASP A 115
ILE A 116
ILE A 144
None
0.78A 6fbnA-1cvmA:
undetectable
6fbnA-1cvmA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HU9_Q_PCFQ202_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE 5A,
MITOCHONDRIAL
CYTOCHROME C OXIDASE
SUBUNIT 1)
1cvm PHYTASE
(Bacillus
amyloliquefacien
s)
4 / 6 TYR A 287
ILE A 231
ALA A 250
ASP A  32
None
1.04A 6hu9m-1cvmA:
undetectable
6hu9q-1cvmA:
undetectable
6hu9m-1cvmA:
21.81
6hu9q-1cvmA:
18.99